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Protein

Solute carrier family 25 member 46

Gene

slc25a46

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in mitochondrial dynamics by controlling mitochondrial membrane fission.By similarity

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 25 member 46
Gene namesi
ORF Names:TEgg014d12.1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-5803974 slc25a46

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei101 – 121Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei161 – 181Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei197 – 217Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei256 – 276Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei312 – 332Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei381 – 401Helical; Name=6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002918351 – 416Solute carrier family 25 member 46Add BLAST416

Proteomic databases

PaxDbiA4IIC3

Expressioni

Gene expression databases

BgeeiENSXETG00000021256
ExpressionAtlasiA4IIC3 baseline

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000058845

Structurei

3D structure databases

ProteinModelPortaliA4IIC3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati94 – 185Solcar 1Add BLAST92
Repeati309 – 414Solcar 2Add BLAST106

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2954 Eukaryota
ENOG410XRFB LUCA
GeneTreeiENSGT00390000015874
HOGENOMiHOG000007981
HOVERGENiHBG059752
InParanoidiA4IIC3
KOiK03454

Family and domain databases

Gene3Di1.50.40.10, 2 hits
InterProiView protein in InterPro
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 2 hits
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 2 hits

Sequencei

Sequence statusi: Complete.

A4IIC3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPRRPDRFD GLEYRGTSWG RGDGDVPPYQ HGFPARSFSS SGDLSQHWVT
60 70 80 90 100
TPPDIPGSRN LHWGEKSPQY GADSNAGPAA VGEESSSSSS GGEHLNRFAG
110 120 130 140 150
FGIGLASLFT ENVLAHPCIV LRRQCQVNYH ARNYQLSPFS IVNIMYSFTK
160 170 180 190 200
TQGFRALWKG MGSTFIVQGI SLGAEGMLSE FTHLPRELNH KWNPKQIGGH
210 220 230 240 250
LLLKGLVYVI VTPFYSASLI ETVQSEIIHD NPGILDCLKE GIGRVLNLGV
260 270 280 290 300
PYSKRLLPLL VLTFPTVLHG ILHYIISSTI QKCVLFFIKK KSPAQLPGDG
310 320 330 340 350
SNAVQNKLED YFPELIANFA ASLCADVLLY PLETVLHRLH IQGTRTIIDN
360 370 380 390 400
TDLGHEVVPI NSQYEGLKDC INTIKREEGG LGFYKGFGAV VVQYTLHAIV
410
LQITKIIYSS VVQTAS
Length:416
Mass (Da):45,834
Last modified:May 1, 2007 - v1
Checksum:i9E8702CB03B36EAA
GO

Sequence cautioni

The sequence CAJ81828 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti59R → C in CAJ81828 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR762049 mRNA Translation: CAJ81828.1 Different initiation.
BC135960 mRNA Translation: AAI35961.1
RefSeqiNP_001016130.1, NM_001016130.2
UniGeneiStr.26824

Genome annotation databases

EnsembliENSXETT00000045970; ENSXETP00000045970; ENSXETG00000021256
GeneIDi548884
KEGGixtr:548884

Similar proteinsi

Entry informationi

Entry nameiS2546_XENTR
AccessioniPrimary (citable) accession number: A4IIC3
Secondary accession number(s): Q28FB7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: May 1, 2007
Last modified: February 28, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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