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Protein

Solute carrier family 25 member 46

Gene

slc25a46

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in mitochondrial dynamics by controlling mitochondrial membrane fission.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 25 member 46
Gene namesi
Name:slc25a46
ORF Names:TEgg014d12.1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-5803974. slc25a46.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei101 – 12121Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei161 – 18121Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei197 – 21721Helical; Name=3Sequence analysisAdd
BLAST
Transmembranei256 – 27621Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei312 – 33221Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei381 – 40121Helical; Name=6Sequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 416416Solute carrier family 25 member 46PRO_0000291835Add
BLAST

Proteomic databases

PaxDbiA4IIC3.

Expressioni

Gene expression databases

BgeeiA4IIC3.
ExpressionAtlasiA4IIC3. baseline.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000058845.

Structurei

3D structure databases

ProteinModelPortaliA4IIC3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati94 – 18592Solcar 1Add
BLAST
Repeati309 – 414106Solcar 2Add
BLAST

Sequence similaritiesi

Contains 2 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2954. Eukaryota.
ENOG410XRFB. LUCA.
GeneTreeiENSGT00390000015874.
HOGENOMiHOG000007981.
HOVERGENiHBG059752.
InParanoidiA4IIC3.
KOiK03454.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 2 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4IIC3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPRRPDRFD GLEYRGTSWG RGDGDVPPYQ HGFPARSFSS SGDLSQHWVT
60 70 80 90 100
TPPDIPGSRN LHWGEKSPQY GADSNAGPAA VGEESSSSSS GGEHLNRFAG
110 120 130 140 150
FGIGLASLFT ENVLAHPCIV LRRQCQVNYH ARNYQLSPFS IVNIMYSFTK
160 170 180 190 200
TQGFRALWKG MGSTFIVQGI SLGAEGMLSE FTHLPRELNH KWNPKQIGGH
210 220 230 240 250
LLLKGLVYVI VTPFYSASLI ETVQSEIIHD NPGILDCLKE GIGRVLNLGV
260 270 280 290 300
PYSKRLLPLL VLTFPTVLHG ILHYIISSTI QKCVLFFIKK KSPAQLPGDG
310 320 330 340 350
SNAVQNKLED YFPELIANFA ASLCADVLLY PLETVLHRLH IQGTRTIIDN
360 370 380 390 400
TDLGHEVVPI NSQYEGLKDC INTIKREEGG LGFYKGFGAV VVQYTLHAIV
410
LQITKIIYSS VVQTAS
Length:416
Mass (Da):45,834
Last modified:May 1, 2007 - v1
Checksum:i9E8702CB03B36EAA
GO

Sequence cautioni

The sequence CAJ81828.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti59 – 591R → C in CAJ81828 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR762049 mRNA. Translation: CAJ81828.1. Different initiation.
BC135960 mRNA. Translation: AAI35961.1.
RefSeqiNP_001016130.1. NM_001016130.2.
UniGeneiStr.26824.

Genome annotation databases

EnsembliENSXETT00000045970; ENSXETP00000045970; ENSXETG00000021256.
GeneIDi548884.
KEGGixtr:548884.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR762049 mRNA. Translation: CAJ81828.1. Different initiation.
BC135960 mRNA. Translation: AAI35961.1.
RefSeqiNP_001016130.1. NM_001016130.2.
UniGeneiStr.26824.

3D structure databases

ProteinModelPortaliA4IIC3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000058845.

Proteomic databases

PaxDbiA4IIC3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSXETT00000045970; ENSXETP00000045970; ENSXETG00000021256.
GeneIDi548884.
KEGGixtr:548884.

Organism-specific databases

CTDi91137.
XenbaseiXB-GENE-5803974. slc25a46.

Phylogenomic databases

eggNOGiKOG2954. Eukaryota.
ENOG410XRFB. LUCA.
GeneTreeiENSGT00390000015874.
HOGENOMiHOG000007981.
HOVERGENiHBG059752.
InParanoidiA4IIC3.
KOiK03454.

Gene expression databases

BgeeiA4IIC3.
ExpressionAtlasiA4IIC3. baseline.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 2 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Sanger Xenopus tropicalis EST/cDNA project
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Egg.
  2. NIH - Xenopus Gene Collection (XGC) project
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiS2546_XENTR
AccessioniPrimary (citable) accession number: A4IIC3
Secondary accession number(s): Q28FB7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: May 1, 2007
Last modified: June 8, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.