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Protein

Hexokinase

Gene

hk1

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. hexokinase activity Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotation, Transferase

Keywords - Biological processi

GlycolysisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_301855. Glucose transport.

Names & Taxonomyi

Protein namesi
Recommended name:
HexokinaseUniRule annotation (EC:2.7.1.1UniRule annotation)
Gene namesi
Name:hk1Imported
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

Organism-specific databases

XenbaseiXB-GENE-944850. hk1.

PTM / Processingi

Proteomic databases

PaxDbiA4II49.

Expressioni

Gene expression databases

BgeeiA4II49.
ExpressionAtlasiA4II49. baseline.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000019458.

Structurei

3D structure databases

ProteinModelPortaliA4II49.
SMRiA4II49. Positions 16-913.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the hexokinase family.UniRule annotation
Contains 2 hexokinase type-1 domains.UniRule annotation
Contains 2 hexokinase type-2 domains.UniRule annotation

Phylogenomic databases

eggNOGiCOG5026.
HOGENOMiHOG000162671.
HOVERGENiHBG005020.
KOiK00844.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 2 hits.
PF03727. Hexokinase_2. 2 hits.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
PROSITEiPS00378. HEXOKINASES. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4II49-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIAAQLLAYY FTELKDDQLK KIDKYLYSMR LSDETLLDIM GRFRAEMANG
60 70 80 90 100
LSRDTNPTAI IKMLPTFVRS IPDGTEKGDF IALDLGGSHF RILRVKVSHE
110 120 130 140 150
KKQTVQMESE IYDTPEDIIH GSGTRLFDHV AECLGDFMQK KQIKDKKLPV
160 170 180 190 200
GFTFSFPCIQ TKIDEGVLVT WTKRFKASGV EGMDVVKLLN KAIKKRGDYE
210 220 230 240 250
ADIMAVVNDT VGTMMTCGFD DQRCEVGIII GTGTNACYME ELRHIDMVEG
260 270 280 290 300
DEGRMCINTE WGAFGDDGCL EDIRSEFDRE IDRGSLNPGK QLFEKMVSGM
310 320 330 340 350
YMGELVRLIL VKMAKEGLLF EGRITPELLT RGKFETKHVS AIEKSKEGLS
360 370 380 390 400
KAKDILTRLG VEPSHEDCIA VQHVCTIVSF RSANLVAATL GGILIRLRDN
410 420 430 440 450
KGVPRLRTTV GIDGSLYKMH PQYARRLHKT VRRLVPESDV RFLLSESGSG
460 470 480 490 500
KGAAMVTAVA YRLSEQRRQI DETLEEFKLS REQLLEVKRR MRIEIENGLR
510 520 530 540 550
KKTHESAKVK MLPTYVRSTP DGTENGDFLA LDLGGTNFRV LLVKIRSGKR
560 570 580 590 600
RTVEMHNKIY AIPIDVMQGT GEELFDHIAH CISDFLDYMG IKGARLPLGF
610 620 630 640 650
TFSFPCMQTS LDAGILVTWT KGFKATDCEG EDVVNLLREG IKRREEFDLD
660 670 680 690 700
VVAIVNDTVG TMMTCAYEDP NCEIGLIVGT GSNACYMEET KNIEMVDGDQ
710 720 730 740 750
GRMCVNMEWG AFGDNGCLDD IRTVYDKAVD DLSLNSGKQR YEKMISGMYL
760 770 780 790 800
GEIVRNILID FTKRGFLFRG QISEALKTTS IFETKFLSQI ESDRLALLQV
810 820 830 840 850
RSILQQLGLN STCDDSIIVK EVCGAVSRRA AQVCGAGMAA VVDKIRENRG
860 870 880 890 900
LDHLDVTVGV DGTLYKLHPH FSKIMHQTVK DLAPKCNVSF LLSEDGSGKG
910
AALITAVACR LRSSEQN
Length:917
Mass (Da):102,488
Last modified:April 30, 2007 - v1
Checksum:i6EDA889A27F75BE9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC135849 mRNA. Translation: AAI35850.1.
RefSeqiNP_001096201.1. NM_001102731.1.
UniGeneiStr.64346.

Genome annotation databases

GeneIDi100124752.
KEGGixtr:100124752.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC135849 mRNA. Translation: AAI35850.1.
RefSeqiNP_001096201.1. NM_001102731.1.
UniGeneiStr.64346.

3D structure databases

ProteinModelPortaliA4II49.
SMRiA4II49. Positions 16-913.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000019458.

Proteomic databases

PaxDbiA4II49.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100124752.
KEGGixtr:100124752.

Organism-specific databases

CTDi3098.
XenbaseiXB-GENE-944850. hk1.

Phylogenomic databases

eggNOGiCOG5026.
HOGENOMiHOG000162671.
HOVERGENiHBG005020.
KOiK00844.

Enzyme and pathway databases

ReactomeiREACT_301855. Glucose transport.

Gene expression databases

BgeeiA4II49.
ExpressionAtlasiA4II49. baseline.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 2 hits.
PF03727. Hexokinase_2. 2 hits.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
PROSITEiPS00378. HEXOKINASES. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Whole embryoImported.

Entry informationi

Entry nameiA4II49_XENTR
AccessioniPrimary (citable) accession number: A4II49
Entry historyi
Integrated into UniProtKB/TrEMBL: April 30, 2007
Last sequence update: April 30, 2007
Last modified: March 31, 2015
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.