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Protein

Early growth response protein 1

Gene

egr1

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Mediates responses to ischemia and hypoxia; regulates the expression of proteins that are involved in inflammatory processes (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri307 – 331C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri337 – 359C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri365 – 387C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Early growth response protein 1By similarity
Short name:
EGR-1By similarity
Gene namesi
Name:egr1Imported
Synonyms:egr1 Publication
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-853412 egr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003864291 – 498Early growth response protein 1Add BLAST498

Proteomic databases

PaxDbiA4II20

Expressioni

Gene expression databases

BgeeiENSXETG00000006697
ExpressionAtlasiA4II20 baseline

Interactioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei305Interaction with DNABy similarity1
Sitei316Interaction with DNABy similarity1
Sitei320Interaction with DNABy similarity1
Sitei326Interaction with DNABy similarity1
Sitei344Interaction with DNABy similarity1
Sitei348Interaction with DNABy similarity1
Sitei372Interaction with DNABy similarity1
Sitei376Interaction with DNABy similarity1
Sitei382Interaction with DNABy similarity1

Protein-protein interaction databases

STRINGi8364.ENSXETP00000047681

Structurei

3D structure databases

ProteinModelPortaliA4II20
SMRiA4II20
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi139 – 183Ser-richSequence analysisAdd BLAST45
Compositional biasi402 – 491Ser-richSequence analysisAdd BLAST90

Domaini

Binds to DNA motifs with the sequence 5'-GCG(T/G)GGGCG-3' via its C2H2-type zinc fingers. The first, most N-terminal zinc finger binds to the 3'-GCG motif, the middle zinc finger interacts with the central TGG motif, and the C-terminal zinc finger binds to the 5'-GCG motif. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Has reduced affinity for target DNA where the cytosines have been oxidized to 5-hydroxymethylcytosine. Does not bind target DNA where the cytosines have been oxidized to 5-formylcytosine or 5-carboxylcytosine.By similarity

Sequence similaritiesi

Belongs to the EGR C2H2-type zinc-finger protein family.Sequence analysis

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri307 – 331C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri337 – 359C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri365 – 387C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00550000074455
HOGENOMiHOG000036856
InParanoidiA4II20
KOiK09203
OMAiQAMESRT
OrthoDBiEOG091G06VX
TreeFamiTF318980

Family and domain databases

InterProiView protein in InterPro
IPR021849 EGR
IPR021839 EGR1_C
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF11914 DUF3432, 1 hit
PF11928 DUF3446, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequencei

Sequence statusi: Complete.

A4II20-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAKTDMLV SPLQISDPFS SFPHSPTMDN YPKLEEMMLL NPGAPQFLGA
60 70 80 90 100
AVPEGSGFNS PVEGSEQFDH LAADAFSDMS LSGEKAVIES SYANQSARLP
110 120 130 140 150
SLTYTGRFSL EPAPNSSNTL WPEPLFSLVS GLVGMANASP SSAPSSSPSS
160 170 180 190 200
SSSSSQSPPL SCSVQSNDSS PIYSAAPTFP NSSPELFPDQ SPQPFQNAST
210 220 230 240 250
ASIPYPPPAY PVSKTTFQVP MIPDYLFPQQ QGDVSLVSAD QKPFQAMESR
260 270 280 290 300
TQQPSLTPLS TIKAFATQTS QDLKTINSTY QSQIIKPSRM RKYPNRPSKT
310 320 330 340 350
PPHERPYACP VESCDRRFSR SDELTRHIRI HTGQKPFQCR ICMRNFSRSD
360 370 380 390 400
HLTTHIRTHT GEKPFACDIC GRKFARSDER KRHTKIHLRQ KDKKADKATP
410 420 430 440 450
VSVASPVSSY SPSASTSYPS PVPTSYSSPV SSAYPSPVHS SFPSPTTAVT
460 470 480 490
YPSVTSTFQT HGITSFPSSI VTNSFSSPVS SALSDMSITY SPRTIEIC
Length:498
Mass (Da):53,997
Last modified:October 13, 2009 - v2
Checksum:iF0A812624C004C74
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti148P → PS in AAI35807 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC146894 Genomic DNA Translation: AAT71995.1
BC135806 mRNA Translation: AAI35807.1
RefSeqiNP_001090830.1, NM_001097361.1
UniGeneiStr.39717

Genome annotation databases

EnsembliENSXETT00000047681; ENSXETP00000047681; ENSXETG00000006697
GeneIDi100038164
KEGGixtr:100038164

Similar proteinsi

Entry informationi

Entry nameiEGR1_XENTR
AccessioniPrimary (citable) accession number: A4II20
Secondary accession number(s): Q6F2L9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 13, 2009
Last sequence update: October 13, 2009
Last modified: March 28, 2018
This is version 73 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health