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Protein

Eukaryotic translation initiation factor 3 subunit A

Gene

eif3a

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 3 subunit AUniRule annotation
Short name:
eIF3aUniRule annotation
Alternative name(s):
Eukaryotic translation initiation factor 3 subunit 10UniRule annotation
eIF-3-thetaUniRule annotation
Gene namesi
Name:eif3a
Synonyms:eif3s10
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-994394. eif3a.

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedUniRule annotation
Chaini2 – 13911390Eukaryotic translation initiation factor 3 subunit APRO_0000366330Add
BLAST

Proteomic databases

PRIDEiA4II09.

Interactioni

Subunit structurei

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: eif3a, eif3b, eif3c, eif3d, eif3e, eif3f, eif3g, eif3h, eif3i, eif3j, eif3k, eif3l and eif3m.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini368 – 494127PCIUniRule annotationAdd
BLAST
Repeati973 – 982101
Repeati983 – 992102
Repeati993 – 100193; approximate
Repeati1002 – 1011104
Repeati1012 – 1021105
Repeati1022 – 1031106
Repeati1032 – 1041107
Repeati1042 – 1051108
Repeati1052 – 1061109
Repeati1062 – 10711010
Repeati1072 – 10811011
Repeati1082 – 10911012
Repeati1092 – 11011013
Repeati1102 – 11111014
Repeati1112 – 1120915
Repeati1122 – 11311016
Repeati1132 – 11411017
Repeati1142 – 11511018
Repeati1152 – 11611019
Repeati1162 – 11711020
Repeati1172 – 11811021
Repeati1182 – 11911022
Repeati1192 – 12011023
Repeati1202 – 1209824; approximate
Repeati1210 – 12191025
Repeati1220 – 12291026

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni973 – 122925726 X 10 AA approximate tandem repeats of [DE]-[DE]-[DE]-R-[GATV]-[PS]-[KRW]-R-G-[AEFGIL]Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi576 – 875300Glu-richAdd
BLAST
Compositional biasi1013 – 1232220Asp-richAdd
BLAST

Sequence similaritiesi

Belongs to the eIF-3 subunit A family.UniRule annotation
Contains 1 PCI domain.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000246822.
HOVERGENiHBG006128.
InParanoidiA4II09.
KOiK03254.

Family and domain databases

HAMAPiMF_03000. eIF3a. 1 hit.
InterProiIPR027512. EIF3A.
IPR000717. PCI_dom.
[Graphical view]
PfamiPF01399. PCI. 1 hit.
[Graphical view]
SMARTiSM00088. PINT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A4II09-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAYFQRPEN ALKRANEFLE VGKKQPALDV LYDVIKSKKH RTWQKIHEPI
60 70 80 90 100
MLKYLELCVD LRKSHLAKEG LYQYKNICQQ VNIKSLEDVV RAYLKLAEER
110 120 130 140 150
TEAAKESSQQ MVLDIEDLDN IQTPESVLLS AVSGEDTQDR TDRLLLTPWV
160 170 180 190 200
KFLWESYRQC LDLLRNNSKV ERLYHDIAQQ AFKFCLLYTR KAEFRKLCDN
210 220 230 240 250
LRMHLSQIQR HHNQSTAINL NNPESQSMHL ETRLVQLDSA ISMELWQEAF
260 270 280 290 300
KAVEDIHGLF ALSKKPPKPQ LMANYYNKVS TVFWKSGNTL FHASTLHRLY
310 320 330 340 350
HLSREMRKNL TQEEMQRMST RVLLATLSIP ITPERTDIAR LLDMDGIILE
360 370 380 390 400
KQRRLATLLG LQAPPTRVGL INDMVRFNML QYVVPEVKEL YNWLEMDFHP
410 420 430 440 450
LKLCTRVTKV LDWVKEQAEK EPELQQYVPQ LQSNTILRLL QQVAQLYQTI
460 470 480 490 500
EFSRLASLVP FVDAFLLERA IVDAARHCDL QVRIDHSSRT LSFGSDLNYS
510 520 530 540 550
TREDAPFGPF LQNMPSEQIR NQLTAMSCVL SKAVGAIKPA HVLQEKEEQH
560 570 580 590 600
QIAITAYQKN SRKEHQRILA RRQTIEERKE RLENLNIQRE KEEMEQKEAE
610 620 630 640 650
LQKVRKAEEE RLRQEAKERE KERILQEHEQ IKKKTVRERL EQIKKTELGA
660 670 680 690 700
KAFKDIDIEN LEELDPDFIM AKQVEQLEKE KKELQERLKN QEKKIDYFER
710 720 730 740 750
AKRLEEIPLL KKAYEEQRIN DMELWELQEE ERISTLLLER EKAVEHKNRM
760 770 780 790 800
SRMVEDKELF VSKLKASRQS LYEAKLKQFQ ERLAEEKAAR LEERKRERKE
810 820 830 840 850
ERRVNYYRDK EEEEERLREE QLKQEREEQE KVENEKREAE QRDYQERLKK
860 870 880 890 900
LEEQERKKRQ RELEIEERER KREEERRGGD DTFRKDSSRW GEREESGWRR
910 920 930 940 950
GADPDERKQV PPERDWRRGG PDSKPVINED ASNREEDENA ALRKDEEQVS
960 970 980 990 1000
SRAFEEKVSL PDADEEKGGS WRDEDRGPKR GLEEDRGPRR GIDDAGPRRG
1010 1020 1030 1040 1050
FEEDRGPRRG IEDDRAPRRG FDDDRGPRRG FDDDRGPRRG FDEDRGPRRG
1060 1070 1080 1090 1100
IDDDRGPRRG FDEDRTPRRG FDDDRGPRRG FDDDRGPRRG FDEDRGPRRG
1110 1120 1130 1140 1150
FEDDRGPRRG FEDDRGPRRG FEDDRGPRRG FEDDRGPRRG FEDDRGPRRG
1160 1170 1180 1190 1200
FDEDRGPRRG FEDDRGPRRG FDEDRTPRRG FDDDRGPRRG LDEDRGSWRG
1210 1220 1230 1240 1250
GDDVPRRGAD DDRGPRRGAD DDRGPRRGED RDQTPWKPMA ASRPGGWRER
1260 1270 1280 1290 1300
EKAREDSWGP PRDSQAPEER EWSRQGEDSE KDSERDRRPV REESAWRRGG
1310 1320 1330 1340 1350
DNSETPRKPS PGDSDRKDDS DKKRPPKTDE ANPWRRGEDK DSREEERGTP
1360 1370 1380 1390
RRAPAADREK SAWRTEKKEE KDTPRRIKPE TDEDGWTTVR R
Length:1,391
Mass (Da):164,997
Last modified:May 1, 2007 - v1
Checksum:i550E7F3DB0C5BDBD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC135790 mRNA. Translation: AAI35791.1.
RefSeqiNP_001096173.1. NM_001102703.1.
UniGeneiStr.55518.

Genome annotation databases

GeneIDi100124719.
KEGGixtr:100124719.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC135790 mRNA. Translation: AAI35791.1.
RefSeqiNP_001096173.1. NM_001102703.1.
UniGeneiStr.55518.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiA4II09.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100124719.
KEGGixtr:100124719.

Organism-specific databases

CTDi8661.
XenbaseiXB-GENE-994394. eif3a.

Phylogenomic databases

HOGENOMiHOG000246822.
HOVERGENiHBG006128.
InParanoidiA4II09.
KOiK03254.

Family and domain databases

HAMAPiMF_03000. eIF3a. 1 hit.
InterProiIPR027512. EIF3A.
IPR000717. PCI_dom.
[Graphical view]
PfamiPF01399. PCI. 1 hit.
[Graphical view]
SMARTiSM00088. PINT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEIF3A_XENTR
AccessioniPrimary (citable) accession number: A4II09
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: May 1, 2007
Last modified: November 11, 2015
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.