Reviewed, UniProtKB/Swiss-Prot A4IHU7 (DUPD1_XENTR)

Names and origin

Protein names

Recommended name:
    Dual specificity phosphatase DUPD1
    EC=3.1.3.48
    EC=3.1.3.16

Gene names

Name:

dupd1

Organism

Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

Taxonomic identifier

8364 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length	209 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. A phosphoprotein + H2O = a protein + phosphate.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. Contains 1 tyrosine-protein phosphatase domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase Protein phosphatase
Gene Ontology (GO)
Biological process	protein amino acid dephosphorylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC protein tyrosine/serine/threonine phosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 209	209	Dual specificity phosphatase DUPD1		PRO_0000295892
Regions
	Domain	45 – 192	148	Tyrosine-protein phosphatase
Sites
	Active site	138	1	Phosphocysteine intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	A4IHU7-1 [UniParc]. Last modified July 24, 2007. Version 2. Checksum: 89BAF4957FF4F7E4	FASTA	209	23,746
	10 20 30 40 50 60 MPADTPIRKK PNAYASVVDP DTGYCTPGAF ELERLFWHGA PKYNHVNEVW PNLYIGDEKT 70 80 90 100 110 120 ALDRYSLEKN GFTHILNAAH GRWNVDTGPE YYSDITVEYY GVEAEDLPSF NLSQFFYPAA 130 140 150 160 170 180 QFIRNALSSP SSKVLVNCAM GRSRSASLVL AYLMIYENMT VVDSIMQVLK HRCILPNRGF 190 200 LKQLRELDIQ LALERRGTED TAKKAQKDD

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC135695 mRNA. Translation: AAI35696.1. Different initiation.
RefSeq	NP_001153481.1.
UniGene	Str.64205
3D structure databases
SMR	A4IHU7. Positions 27-192.
ModBase	Search...
Genome annotation databases
GeneID	100124898.
KEGG	xtr:100124898.
Organism-specific databases
CTD	100124898.
Xenbase	XB-FEAT-5944518. dupd1.
Phylogenomic databases
eggNOG	veNOG15113.
Enzyme and pathway databases
BRENDA	3.1.3.16. 279072. 3.1.3.48. 279072.
Family and domain databases
InterPro	IPR000387. Dual-sp/Tyr_phosphatase. IPR020417. Dual-sp_phosphatase. IPR000340. Dual-sp_phosphatase_cat-dom. IPR020405. Dual-sp_phosphatase_famA. IPR020422. Dual-sp_phosphatase_subgr_cat. [Graphical view]
Pfam	PF00782. DSPc. 1 hit. [Graphical view]
PRINTS	PR01908. ADSPHPHTASE. PR01909. ADSPHPHTASEA.
SMART	SM00195. DSPc. 1 hit. [Graphical view]
PROSITE	PS00383. TYR_PHOSPHATASE_1. False negative. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50054. TYR_PHOSPHATASE_DUAL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DUPD1_XENTR

Accession

Primary (citable) accession number: A4IHU7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 24, 2007
Last sequence update:	July 24, 2007
Last modified:	January 19, 2010
This is version 19 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Xenopus annotation project