A4IHU7 (DUPD1_XENTR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dual specificity phosphatase DUPD1
EC=3.1.3.16
EC=3.1.3.48

Gene names

Name:

dupd1

Organism

Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]

Taxonomic identifier

8364 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length	209 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. A phosphoprotein + H2O = a protein + phosphate.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. Contains 1 tyrosine-protein phosphatase domain.
Sequence caution	The sequence AAI35696.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	peptidyl-tyrosine dephosphorylation Inferred from electronic annotation. Source: GOC
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC protein tyrosine/serine/threonine phosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 209	209	Dual specificity phosphatase DUPD1		PRO_0000295892
Regions
	Domain	45 – 192	148	Tyrosine-protein phosphatase
	Region	137 – 144	8	Substrate binding By similarity
Sites
	Active site	138	1	Phosphocysteine intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	A4IHU7 [UniParc]. Last modified July 24, 2007. Version 2. Checksum: 89BAF4957FF4F7E4	FASTA	209	23,746
	10 20 30 40 50 60 MPADTPIRKK PNAYASVVDP DTGYCTPGAF ELERLFWHGA PKYNHVNEVW PNLYIGDEKT 70 80 90 100 110 120 ALDRYSLEKN GFTHILNAAH GRWNVDTGPE YYSDITVEYY GVEAEDLPSF NLSQFFYPAA 130 140 150 160 170 180 QFIRNALSSP SSKVLVNCAM GRSRSASLVL AYLMIYENMT VVDSIMQVLK HRCILPNRGF 190 200 LKQLRELDIQ LALERRGTED TAKKAQKDD

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC135695 mRNA. Translation: AAI35696.1. Different initiation.
RefSeq	NP_001153481.1. NM_001160009.1.
UniGene	Str.64205.
3D structure databases
ProteinModelPortal	A4IHU7.
SMR	A4IHU7. Positions 27-192.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	100124898.
KEGG	xtr:100124898.
Organism-specific databases
CTD	338599.
Xenbase	XB-GENE-5944519. dupd1.
Phylogenomic databases
eggNOG	COG2453.
HOGENOM	HOG000233767.
HOVERGEN	HBG001524.
KO	K14165.
Family and domain databases
InterPro	IPR020417. Atypical_DUSP. IPR020405. Atypical_DUSP_famA. IPR000340. Dual-sp_phosphatase_cat-dom. IPR020422. Dual-sp_phosphatase_subgr_cat. IPR024950. DUSP. IPR000387. Tyr/Dual-sp_Pase. [Graphical view]
PANTHER	PTHR10159. PTHR10159. 1 hit.
Pfam	PF00782. DSPc. 1 hit. [Graphical view]
PRINTS	PR01908. ADSPHPHTASE. PR01909. ADSPHPHTASEA.
SMART	SM00195. DSPc. 1 hit. [Graphical view]
PROSITE	PS00383. TYR_PHOSPHATASE_1. False negative. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50054. TYR_PHOSPHATASE_DUAL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DUPD1_XENTR

Accession

Primary (citable) accession number: A4IHU7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 24, 2007
Last sequence update:	July 24, 2007
Last modified:	March 6, 2013
This is version 37 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program