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A4IGY9 (SETB2_XENTR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histone-lysine N-methyltransferase SETDB2

EC=2.1.1.43
Alternative name(s):
SET domain bifurcated 2
Gene names
Name:setdb2
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

Protein attributes

Sequence length697 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis By similarity.

Catalytic activity

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

Subcellular location

Nucleus By similarity. Chromosome By similarity.

Sequence similarities

Belongs to the class V-like SAM-binding methyltransferase superfamily.

Contains 1 MBD (methyl-CpG-binding) domain.

Contains 1 pre-SET domain.

Contains 1 SET domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 697697Histone-lysine N-methyltransferase SETDB2
PRO_0000398647

Regions

Domain172 – 24271MBD
Domain304 – 37875Pre-SET
Domain381 – 672292SET

Sites

Metal binding3061Zinc 1 By similarity
Metal binding3061Zinc 2 By similarity
Metal binding3081Zinc 1 By similarity
Metal binding3121Zinc 1 By similarity
Metal binding3121Zinc 3 By similarity
Metal binding3181Zinc 1 By similarity
Metal binding3201Zinc 2 By similarity
Metal binding3591Zinc 2 By similarity
Metal binding3591Zinc 3 By similarity
Metal binding3631Zinc 2 By similarity
Metal binding3651Zinc 3 By similarity
Metal binding3701Zinc 3 By similarity

Sequences

Sequence LengthMass (Da)Tools
A4IGY9 [UniParc].

Last modified May 1, 2007. Version 1.
Checksum: 355475082EA9861D

FASTA69778,015
        10         20         30         40         50         60 
MERSTNARHS TLSSWTRESN TLSVLSKDVS LEDAKEYWKD CQADGKVDWI FEKLLNKLKI 

        70         80         90        100        110        120 
LWQKIKDGSA TNLEYVRAVI LVNEAEQLEE DTETLHTDIQ KENKVQENTD CAPERKEDSC 

       130        140        150        160        170        180 
ADLNSDCETD VSGSECEHED HSTVSPPATG AVCFGKHLCG PSCLSDINPS LLKKENPLNL 

       190        200        210        220        230        240 
PVSCDFQRWR VKTNGSEYPP HILYKAPCGR SLRDSDEVHS YLTETGCHFL GVDNFSFSTQ 

       250        260        270        280        290        300 
VQLESHLSIK QEIVQDCDIS NDVESVPVSL SNEIDDTRPT NFIYRKTSWP PGYSINNFTD 

       310        320        330        340        350        360 
IFVKCCSCTD GCLDISTCSC LQLTAQAFEK FTDSSLGIGP LGYKHKRLQE PVPTGLYECN 

       370        380        390        400        410        420 
LSCKCDRTLC QNRVVQHGLQ LRLQVFKTDT KGWGVRCLDD VDNGTFVCIY AGRILIRTAD 

       430        440        450        460        470        480 
SSVKTTLEDS VACGNEAKED NGSTSTLMLS KRKRKPSHSD SEVTVMHLTP YSMRSLGLSV 

       490        500        510        520        530        540 
HRQSNTLSLT HLRSGGREIS LEPFRRPKTK TSMLQKRRRQ LIEEGACTVH NSSEEEGPTP 

       550        560        570        580        590        600 
PQSPKQKFNA GRKIHRNENS DETASGYVSE ESSSSVISGG HPSEKPTCRT KSKLNKMTPH 

       610        620        630        640        650        660 
LSTSPEQTCE EDLHFLDASK EGNVGRFLNH SCCPNLFVQH VFVDTHQKSF PWVAFFTNSV 

       670        680        690 
VKAGTELTWD YNYVIGTAPD QEIQCLCGQQ TCKHKIV 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC135302 mRNA. Translation: AAI35303.1.
RefSeqNP_001096194.1. NM_001102724.2.
UniGeneStr.16757.

3D structure databases

ProteinModelPortalA4IGY9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING8364.ENSXETP00000034176.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100124743.
KEGGxtr:100124743.

Organism-specific databases

CTD83852.
XenbaseXB-GENE-1219030. setdb2.

Phylogenomic databases

eggNOGCOG2940.
HOGENOMHOG000060314.
HOVERGENHBG106688.
KOK11421.

Family and domain databases

InterProIPR016177. DNA-bd_dom.
IPR001739. Methyl_CpG_DNA-bd.
IPR007728. Pre-SET_dom.
IPR001214. SET_dom.
[Graphical view]
PfamPF01429. MBD. 1 hit.
PF05033. Pre-SET. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
SMARTSM00317. SET. 1 hit.
[Graphical view]
SUPFAMSSF54171. SSF54171. 1 hit.
PROSITEPS50982. MBD. 1 hit.
PS50867. PRE_SET. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSETB2_XENTR
AccessionPrimary (citable) accession number: A4IGY9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: May 1, 2007
Last modified: April 16, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families