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Protein

Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase

Gene

LOC100037907

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

UDP-alpha-D-glucuronate + [protein]-3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine = UDP + [protein]-3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine.UniRule annotation

Cofactori

Mn2+UniRule annotation

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotation
LigandManganeseUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

ReactomeiR-XTR-1971475. A tetrasaccharide linker sequence is required for GAG synthesis.
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT43. Glycosyltransferase Family 43.

Names & Taxonomyi

Protein namesi
Recommended name:
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferaseUniRule annotation (EC:2.4.1.135UniRule annotation)
Gene namesi
Name:LOC100037907Imported
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-961613.

Subcellular locationi

  • Golgi apparatus membrane UniRule annotation; Single-pass type II membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 38HelicalUniRule annotationAdd BLAST19

GO - Cellular componenti

Keywords - Cellular componenti

Golgi apparatusUniRule annotation, Membrane

Expressioni

Gene expression databases

BgeeiENSXETG00000008325.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000018256.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 43 family.UniRule annotation

Keywords - Domaini

Signal-anchorUniRule annotation, Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG1476. Eukaryota.
ENOG410XP79. LUCA.
GeneTreeiENSGT00390000017640.
HOGENOMiHOG000261693.
HOVERGENiHBG050650.
KOiK00735.
OMAiKDEGSDP.
OrthoDBiEOG091G0G8P.
TreeFamiTF313522.

Family and domain databases

CDDicd00218. GlcAT-I. 1 hit.
Gene3Di3.90.550.10. 1 hit.
InterProiView protein in InterPro
IPR005027. Glyco_trans_43.
IPR029044. Nucleotide-diphossugar_trans.
PANTHERiPTHR10896. PTHR10896. 1 hit.
PfamiView protein in Pfam
PF03360. Glyco_transf_43. 1 hit.
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Complete.

A4IGU2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNEEHWGQP TLEMLKRRDI LAIVLIVLPW TLLITVWHHS TLSPLLTAHK
60 70 80 90 100
EDGSEGRRDV SQGSDSREYC SSDRDIVEVV RTEYVYTRPP PWMGNLPIIH
110 120 130 140 150
VITPTYSRPV QKAELTRLSN TLLHVPNLHW ILVEDSQRRT PLVTRLLQDS
160 170 180 190 200
GLNYTHLNVE TPRNYKLRGD TRDPRIPRGT MQRNLALRWL RETFNRNNSL
210 220 230 240 250
PGVVYFADDD NTYSLDLFEE MRSTRKVSVW PVAFVGGLRY ESPKVNAAGK
260 270 280 290 300
VFGWKTVFDP HRPFAIDMAG FAINLRLILQ RPQAYFKLRG VKGGYQESSL
310 320 330 340
LRELVTLNDL EPKADNCTKI LVWHTRTEKP VLVNEGKKGF TDPNVEI
Length:347
Mass (Da):39,989
Last modified:May 1, 2007 - v1
Checksum:i3EEB823C3BF44A99
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAMC01075613 Genomic DNA. No translation available.
AAMC01075614 Genomic DNA. No translation available.
AAMC01075615 Genomic DNA. No translation available.
AAMC01075616 Genomic DNA. No translation available.
AAMC01075617 Genomic DNA. No translation available.
AAMC01075618 Genomic DNA. No translation available.
AAMC01075619 Genomic DNA. No translation available.
AAMC01075620 Genomic DNA. No translation available.
AAMC01075621 Genomic DNA. No translation available.
BC135247 mRNA. Translation: AAI35248.1.
RefSeqiNP_001090809.1. NM_001097340.1.
UniGeneiStr.40135.

Genome annotation databases

EnsembliENSXETT00000018256; ENSXETP00000018256; ENSXETG00000008325.
GeneIDi100037907.
KEGGixtr:100037907.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiA4IGU2_XENTR
AccessioniPrimary (citable) accession number: A4IGU2
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2007
Last sequence update: May 1, 2007
Last modified: July 5, 2017
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported