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Protein

Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase

Gene

b3gat1

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

UDP-alpha-D-glucuronate + [protein]-3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine = UDP + [protein]-3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine.UniRule annotation

Cofactori

Mn2+UniRule annotation

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotation
LigandManganeseUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

ReactomeiR-XTR-1971475 A tetrasaccharide linker sequence is required for GAG synthesis
UniPathwayiUPA00378

Protein family/group databases

CAZyiGT43 Glycosyltransferase Family 43

Names & Taxonomyi

Protein namesi
Recommended name:
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferaseUniRule annotation (EC:2.4.1.135UniRule annotation)
Gene namesi
Name:b3gat1Imported
Synonyms:LOC100037907Imported
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-961613 b3gat1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 38HelicalUniRule annotationAdd BLAST19

Keywords - Cellular componenti

Golgi apparatusUniRule annotation, Membrane

Expressioni

Gene expression databases

BgeeiENSXETG00000008325

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000018256

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 43 family.UniRule annotation

Keywords - Domaini

Signal-anchorUniRule annotation, Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG1476 Eukaryota
ENOG410XP79 LUCA
GeneTreeiENSGT00390000017640
HOGENOMiHOG000261693
HOVERGENiHBG050650
KOiK00735
OMAiCASDKDI
OrthoDBiEOG091G0G8P
TreeFamiTF313522

Family and domain databases

CDDicd00218 GlcAT-I, 1 hit
Gene3Di3.90.550.10, 1 hit
InterProiView protein in InterPro
IPR005027 Glyco_trans_43
IPR029044 Nucleotide-diphossugar_trans
PANTHERiPTHR10896 PTHR10896, 1 hit
PfamiView protein in Pfam
PF03360 Glyco_transf_43, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit

Sequencei

Sequence statusi: Complete.

A4IGU2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNEEHWGQP TLEMLKRRDI LAIVLIVLPW TLLITVWHHS TLSPLLTAHK
60 70 80 90 100
EDGSEGRRDV SQGSDSREYC SSDRDIVEVV RTEYVYTRPP PWMGNLPIIH
110 120 130 140 150
VITPTYSRPV QKAELTRLSN TLLHVPNLHW ILVEDSQRRT PLVTRLLQDS
160 170 180 190 200
GLNYTHLNVE TPRNYKLRGD TRDPRIPRGT MQRNLALRWL RETFNRNNSL
210 220 230 240 250
PGVVYFADDD NTYSLDLFEE MRSTRKVSVW PVAFVGGLRY ESPKVNAAGK
260 270 280 290 300
VFGWKTVFDP HRPFAIDMAG FAINLRLILQ RPQAYFKLRG VKGGYQESSL
310 320 330 340
LRELVTLNDL EPKADNCTKI LVWHTRTEKP VLVNEGKKGF TDPNVEI
Length:347
Mass (Da):39,989
Last modified:May 1, 2007 - v1
Checksum:i3EEB823C3BF44A99
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAMC01075613 Genomic DNA No translation available.
AAMC01075614 Genomic DNA No translation available.
AAMC01075615 Genomic DNA No translation available.
AAMC01075616 Genomic DNA No translation available.
AAMC01075617 Genomic DNA No translation available.
AAMC01075618 Genomic DNA No translation available.
AAMC01075619 Genomic DNA No translation available.
AAMC01075620 Genomic DNA No translation available.
AAMC01075621 Genomic DNA No translation available.
BC135247 mRNA Translation: AAI35248.1
RefSeqiNP_001090809.1, NM_001097340.1
UniGeneiStr.40135

Genome annotation databases

EnsembliENSXETT00000018256; ENSXETP00000018256; ENSXETG00000008325
GeneIDi100037907
KEGGixtr:100037907

Similar proteinsi

Entry informationi

Entry nameiA4IGU2_XENTR
AccessioniPrimary (citable) accession number: A4IGU2
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2007
Last sequence update: May 1, 2007
Last modified: April 25, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health