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A4IGL7

- PXDN_XENTR

UniProt

A4IGL7 - PXDN_XENTR

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Protein

Peroxidasin

Gene
pxdn, pxn
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

2 phenolic donor + H2O2 = 2 phenoxyl radical of the donor + 2 H2O.

Cofactori

Binds 1 calcium ion per subunit By similarity.
Binds 1 heme B (iron-protoporphyrin IX) group covalently per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei815 – 8151Heme (covalent; via 2 links) By similarity
Active sitei816 – 8161Proton acceptor By similarity
Metal bindingi817 – 8171Calcium By similarity
Metal bindingi896 – 8961Calcium By similarity
Metal bindingi898 – 8981Calcium; via carbonyl oxygen By similarity
Metal bindingi900 – 9001Calcium By similarity
Metal bindingi902 – 9021Calcium By similarity
Sitei966 – 9661Transition state stabilizer By similarity
Binding sitei969 – 9691Heme (covalent; via 2 links) By similarity
Metal bindingi1063 – 10631Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. metal ion binding Source: UniProtKB-KW
  3. peroxidase activity Source: UniProtKB-KW

GO - Biological processi

  1. hydrogen peroxide catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Calcium, Heme, Iron, Metal-binding

Protein family/group databases

MEROPSiI43.001.
PeroxiBasei4051. XtPxd.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxidasin (EC:1.11.1.7)
Gene namesi
Name:pxdn
Synonyms:pxn
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-923300. pxdn.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed predictionAdd
BLAST
Chaini26 – 14571432PeroxidasinPRO_0000319621Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi257 ↔ 307 By similarity
Disulfide bondi353 ↔ 402 By similarity
Disulfide bondi444 ↔ 492 By similarity
Disulfide bondi536 ↔ 584 By similarity
Glycosylationi630 – 6301N-linked (GlcNAc...) Reviewed prediction
Glycosylationi689 – 6891N-linked (GlcNAc...) Reviewed prediction
Glycosylationi709 – 7091N-linked (GlcNAc...) Reviewed prediction
Glycosylationi721 – 7211N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi722 ↔ 738 By similarity
Disulfide bondi836 ↔ 846 By similarity
Disulfide bondi840 ↔ 864 By similarity
Disulfide bondi948 ↔ 959 By similarity
Disulfide bondi1166 ↔ 1223 By similarity
Glycosylationi1167 – 11671N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1264 ↔ 1290 By similarity
Glycosylationi1269 – 12691N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1343 – 13431N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1347 – 13471N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1434 – 14341N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiA4IGL7.

Expressioni

Developmental stagei

Maternal expression is localized to the animal hemisphere where it persists through early cleavage stages. Initial zygotic expression is detected in the developing neural tube and becomes localized to the hindbrain and midbrain. Expressed in the primordium of the pronephric kidney and expression persists in the pronephric tubules and duct throughout development.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000015184.

Structurei

3D structure databases

ProteinModelPortaliA4IGL7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 5227LRRNTAdd
BLAST
Repeati53 – 7422LRR 1Add
BLAST
Repeati77 – 9822LRR 2Add
BLAST
Repeati101 – 12222LRR 3Add
BLAST
Repeati125 – 14622LRR 4Add
BLAST
Repeati149 – 17022LRR 5Add
BLAST
Domaini182 – 23554LRRCTAdd
BLAST
Domaini236 – 32489Ig-like C2-type 1Add
BLAST
Domaini332 – 41887Ig-like C2-type 2Add
BLAST
Domaini423 – 51088Ig-like C2-type 3Add
BLAST
Domaini515 – 60086Ig-like C2-type 4Add
BLAST
Domaini1392 – 145059VWFCAdd
BLAST

Sequence similaritiesi

Contains 1 LRRCT domain.
Contains 1 LRRNT domain.
Contains 1 VWFC domain.

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiNOG295125.
HOVERGENiHBG108312.

Family and domain databases

Gene3Di1.10.640.10. 2 hits.
2.60.40.10. 4 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR010255. Haem_peroxidase.
IPR019791. Haem_peroxidase_animal.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
IPR001007. VWF_C.
[Graphical view]
PfamiPF03098. An_peroxidase. 1 hit.
PF07679. I-set. 4 hits.
PF00560. LRR_1. 1 hit.
PF13855. LRR_8. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view]
PRINTSiPR00457. ANPEROXIDASE.
SMARTiSM00408. IGc2. 4 hits.
SM00369. LRR_TYP. 4 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMiSSF48113. SSF48113. 1 hit.
PROSITEiPS50835. IG_LIKE. 4 hits.
PS51450. LRR. 5 hits.
PS50292. PEROXIDASE_3. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A4IGL7-1 [UniParc]FASTAAdd to Basket

« Hide

MAGAGSWLYL TAGLLVVALP QLSHSCPSRC LCFRTTVRCM HLMLESVPAV     50
PPHTTILDLR FNRIKDIQTG AFKHLKNLNT LLLNNNQIKR IPSEAFKDLE 100
NLKYLYLYKN EIQSIDRQAF KGLASLEQLY LHFNQIETLE PESFNYLPKL 150
ERLFLHNNRI THLVPGTFSQ LESMKRLRLD SNALHCDCEI LWLADLLKIY 200
SESGNAQAAA TCEYPRRLQG RSVSTITPSE LNCERPRITS EPQDVDVTFG 250
NTVYFTCRAE GNPKPEIIWL RNNNELSMKD DSRLNLLNDG TLMIQNTKET 300
DQGIYQCMAK NVAGEVKTHE VTLRYYGTPA TPTFVIQPQN TEVLVGESVT 350
LECSATGQPH PRVTWTRGDR TPLPSDPRIN ITPSGGLYIQ NVNQDDAGEY 400
TCFATNSVET IHSTAYIIVQ AVPQFTVVPQ DRNVFEGHTV DFHCEAQGNP 450
KPVIAWTKGG NQLSVDRRHQ VLSSGTLRIL RVALHDQGQY ECQAVNIVGS 500
KSTAAQLIVQ TRVTPVFATV PNDMTVEVGT DVQIPCSSQG DPLPIITWNK 550
DGIQVTESGK FHISPHGYLA IRDAGLADQG RYECVARNPI GYSSVSMVLS 600
VLVPEVSRTG DPFVATSIIE AIATVDRAIN STRTHLFDSR PRSPGDLLAL 650
FRYPRDPYTV EQARAAEIFE RTLQLIQDHV QSGLMVDLNG TSYHYNDLVS 700
PQYLNMIANL SGCATHRRIN NCSNMCFHQK YRTHDGTCNN LQHPMWGASL 750
TAFERLLKSV YENGFNLPRG ISGRIYNGFP LPLPRLVSTT LIGTHTITPD 800
EQFTHMLMQW GQFLDHDLDS TVVALSQARF SDGQDCSVVC TNDAPCFPIM 850
VPPNDPRVRN NARCMSMVRS SPVCGSGMTS LLMNSVYPRE QMNQLTSYID 900
ASNVYGSSDH ESNEIRDSAS HRGLLKQGIV QRSGKPLLPF ATGPPTECMR 950
DENESPIPCF LAGDHRANEQ LGLTSMHTLW FREHNRIATE LLRLNPHWDG 1000
DTIYHETRKI VGAQMQHITY SHWLPKIFGD VGMKMLGEYK SYDPNVNAGI 1050
LNEFATAAFR FGHTLINPIL YRLDEKFEPI PQGHVPLHRA FFSPFRIVNE 1100
GGIDPLLRGL IGVAAKMRVT SQLLNTELTE KLFSMAHAVA LDLAALNVQR 1150
GRDHGIPPYH DFRVFCNLST VQTFDDLRNE IKNPDVREKL KRLYGSPLNI 1200
DLFPALMVED LIPGSRLGPT LMCLLTTQFR NIRDGDRFWY ENPGVFTAAQ 1250
LTQIKQTSLA RVLCDNGDNI TKVQHDLFRV AEFPHGYVSC KNIAKMDLRV 1300
WQDCCEDCRT RGQFSTFSNH FRGKRSTEHS YKEDNKEPSS LLNQSVNTTC 1350
NTEQPKNLPH VNDFKEFVLD MQKTITGLRK QIKKLESRLS NTDCTDETGE 1400
SHSTKEKWNK DACTKCECYN GHITCFVKSC PPVNCSRPQR IEGVCCPVCT 1450
DDKIQST 1457
Length:1,457
Mass (Da):163,914
Last modified:May 1, 2007 - v1
Checksum:i902697AA1C02311A
GO

Sequence cautioni

The sequence DAA05635.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC135155 mRNA. Translation: AAI35156.1.
BK005589 Genomic DNA. Translation: DAA05635.1. Different initiation.
RefSeqiNP_001076815.1. NM_001083346.1.
UniGeneiStr.25013.

Genome annotation databases

GeneIDi493201.
KEGGixtr:493201.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC135155 mRNA. Translation: AAI35156.1 .
BK005589 Genomic DNA. Translation: DAA05635.1 . Different initiation.
RefSeqi NP_001076815.1. NM_001083346.1.
UniGenei Str.25013.

3D structure databases

ProteinModelPortali A4IGL7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 8364.ENSXETP00000015184.

Protein family/group databases

MEROPSi I43.001.
PeroxiBasei 4051. XtPxd.

Proteomic databases

PRIDEi A4IGL7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 493201.
KEGGi xtr:493201.

Organism-specific databases

CTDi 7837.
Xenbasei XB-GENE-923300. pxdn.

Phylogenomic databases

eggNOGi NOG295125.
HOVERGENi HBG108312.

Family and domain databases

Gene3Di 1.10.640.10. 2 hits.
2.60.40.10. 4 hits.
InterProi IPR000483. Cys-rich_flank_reg_C.
IPR010255. Haem_peroxidase.
IPR019791. Haem_peroxidase_animal.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF03098. An_peroxidase. 1 hit.
PF07679. I-set. 4 hits.
PF00560. LRR_1. 1 hit.
PF13855. LRR_8. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view ]
PRINTSi PR00457. ANPEROXIDASE.
SMARTi SM00408. IGc2. 4 hits.
SM00369. LRR_TYP. 4 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view ]
SUPFAMi SSF48113. SSF48113. 1 hit.
PROSITEi PS50835. IG_LIKE. 4 hits.
PS51450. LRR. 5 hits.
PS50292. PEROXIDASE_3. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.
  2. "Xenopus tropicalis peroxidasin gene is expressed within the developing neural tube and pronephric kidney."
    Tindall A.J., Pownall M.E., Morris I.D., Isaacs H.V.
    Dev. Dyn. 232:377-384(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiPXDN_XENTR
AccessioniPrimary (citable) accession number: A4IGL7
Secondary accession number(s): Q5HZ61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 1, 2007
Last modified: September 3, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi