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A4IGL7 (PXDN_XENTR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Peroxidasin
EC=1.11.1.7
Gene names
Name:pxdn
Synonyms:pxn
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length1457 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

2 phenolic donor + H2O2 = 2 phenoxyl radical of the donor + 2 H2O.

Cofactor

Binds 1 calcium ion per subunit By similarity.

Binds 1 heme B (iron-protoporphyrin IX) group covalently per subunit By similarity.

Subcellular location

Secreted By similarity.

Developmental stage

Maternal expression is localized to the animal hemisphere where it persists through early cleavage stages. Initial zygotic expression is detected in the developing neural tube and becomes localized to the hindbrain and midbrain. Expressed in the primordium of the pronephric kidney and expression persists in the pronephric tubules and duct throughout development. Ref.2

Sequence similarities

Belongs to the peroxidase family. XPO subfamily.

Contains 4 Ig-like C2-type (immunoglobulin-like) domains.

Contains 5 LRR (leucine-rich) repeats.

Contains 1 LRRCT domain.

Contains 1 LRRNT domain.

Contains 1 VWFC domain.

Sequence caution

The sequence DAA05635.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processHydrogen peroxide
   Cellular componentSecreted
   DomainImmunoglobulin domain
Leucine-rich repeat
Repeat
Signal
   LigandCalcium
Heme
Iron
Metal-binding
   Molecular functionOxidoreductase
Peroxidase
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processhydrogen peroxide catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionheme binding

Inferred from electronic annotation. Source: InterPro

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

peroxidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 14571432Peroxidasin
PRO_0000319621

Regions

Domain26 – 5227LRRNT
Repeat53 – 7422LRR 1
Repeat77 – 9822LRR 2
Repeat101 – 12222LRR 3
Repeat125 – 14622LRR 4
Repeat149 – 17022LRR 5
Domain182 – 23554LRRCT
Domain236 – 32489Ig-like C2-type 1
Domain332 – 41887Ig-like C2-type 2
Domain423 – 51088Ig-like C2-type 3
Domain515 – 60086Ig-like C2-type 4
Domain1392 – 145059VWFC

Sites

Active site8161Proton acceptor By similarity
Metal binding8171Calcium By similarity
Metal binding8961Calcium By similarity
Metal binding8981Calcium; via carbonyl oxygen By similarity
Metal binding9001Calcium By similarity
Metal binding9021Calcium By similarity
Metal binding10631Iron (heme axial ligand) By similarity
Binding site8151Heme (covalent; via 2 links) By similarity
Binding site9691Heme (covalent; via 2 links) By similarity
Site9661Transition state stabilizer By similarity

Amino acid modifications

Glycosylation6301N-linked (GlcNAc...) Potential
Glycosylation6891N-linked (GlcNAc...) Potential
Glycosylation7091N-linked (GlcNAc...) Potential
Glycosylation7211N-linked (GlcNAc...) Potential
Glycosylation11671N-linked (GlcNAc...) Potential
Glycosylation12691N-linked (GlcNAc...) Potential
Glycosylation13431N-linked (GlcNAc...) Potential
Glycosylation13471N-linked (GlcNAc...) Potential
Glycosylation14341N-linked (GlcNAc...) Potential
Disulfide bond257 ↔ 307 By similarity
Disulfide bond353 ↔ 402 By similarity
Disulfide bond444 ↔ 492 By similarity
Disulfide bond536 ↔ 584 By similarity
Disulfide bond722 ↔ 738 By similarity
Disulfide bond836 ↔ 846 By similarity
Disulfide bond840 ↔ 864 By similarity
Disulfide bond948 ↔ 959 By similarity
Disulfide bond1166 ↔ 1223 By similarity
Disulfide bond1264 ↔ 1290 By similarity

Sequences

Sequence LengthMass (Da)Tools
A4IGL7 [UniParc].

Last modified May 1, 2007. Version 1.
Checksum: 902697AA1C02311A

FASTA1,457163,914
        10         20         30         40         50         60 
MAGAGSWLYL TAGLLVVALP QLSHSCPSRC LCFRTTVRCM HLMLESVPAV PPHTTILDLR 

        70         80         90        100        110        120 
FNRIKDIQTG AFKHLKNLNT LLLNNNQIKR IPSEAFKDLE NLKYLYLYKN EIQSIDRQAF 

       130        140        150        160        170        180 
KGLASLEQLY LHFNQIETLE PESFNYLPKL ERLFLHNNRI THLVPGTFSQ LESMKRLRLD 

       190        200        210        220        230        240 
SNALHCDCEI LWLADLLKIY SESGNAQAAA TCEYPRRLQG RSVSTITPSE LNCERPRITS 

       250        260        270        280        290        300 
EPQDVDVTFG NTVYFTCRAE GNPKPEIIWL RNNNELSMKD DSRLNLLNDG TLMIQNTKET 

       310        320        330        340        350        360 
DQGIYQCMAK NVAGEVKTHE VTLRYYGTPA TPTFVIQPQN TEVLVGESVT LECSATGQPH 

       370        380        390        400        410        420 
PRVTWTRGDR TPLPSDPRIN ITPSGGLYIQ NVNQDDAGEY TCFATNSVET IHSTAYIIVQ 

       430        440        450        460        470        480 
AVPQFTVVPQ DRNVFEGHTV DFHCEAQGNP KPVIAWTKGG NQLSVDRRHQ VLSSGTLRIL 

       490        500        510        520        530        540 
RVALHDQGQY ECQAVNIVGS KSTAAQLIVQ TRVTPVFATV PNDMTVEVGT DVQIPCSSQG 

       550        560        570        580        590        600 
DPLPIITWNK DGIQVTESGK FHISPHGYLA IRDAGLADQG RYECVARNPI GYSSVSMVLS 

       610        620        630        640        650        660 
VLVPEVSRTG DPFVATSIIE AIATVDRAIN STRTHLFDSR PRSPGDLLAL FRYPRDPYTV 

       670        680        690        700        710        720 
EQARAAEIFE RTLQLIQDHV QSGLMVDLNG TSYHYNDLVS PQYLNMIANL SGCATHRRIN 

       730        740        750        760        770        780 
NCSNMCFHQK YRTHDGTCNN LQHPMWGASL TAFERLLKSV YENGFNLPRG ISGRIYNGFP 

       790        800        810        820        830        840 
LPLPRLVSTT LIGTHTITPD EQFTHMLMQW GQFLDHDLDS TVVALSQARF SDGQDCSVVC 

       850        860        870        880        890        900 
TNDAPCFPIM VPPNDPRVRN NARCMSMVRS SPVCGSGMTS LLMNSVYPRE QMNQLTSYID 

       910        920        930        940        950        960 
ASNVYGSSDH ESNEIRDSAS HRGLLKQGIV QRSGKPLLPF ATGPPTECMR DENESPIPCF 

       970        980        990       1000       1010       1020 
LAGDHRANEQ LGLTSMHTLW FREHNRIATE LLRLNPHWDG DTIYHETRKI VGAQMQHITY 

      1030       1040       1050       1060       1070       1080 
SHWLPKIFGD VGMKMLGEYK SYDPNVNAGI LNEFATAAFR FGHTLINPIL YRLDEKFEPI 

      1090       1100       1110       1120       1130       1140 
PQGHVPLHRA FFSPFRIVNE GGIDPLLRGL IGVAAKMRVT SQLLNTELTE KLFSMAHAVA 

      1150       1160       1170       1180       1190       1200 
LDLAALNVQR GRDHGIPPYH DFRVFCNLST VQTFDDLRNE IKNPDVREKL KRLYGSPLNI 

      1210       1220       1230       1240       1250       1260 
DLFPALMVED LIPGSRLGPT LMCLLTTQFR NIRDGDRFWY ENPGVFTAAQ LTQIKQTSLA 

      1270       1280       1290       1300       1310       1320 
RVLCDNGDNI TKVQHDLFRV AEFPHGYVSC KNIAKMDLRV WQDCCEDCRT RGQFSTFSNH 

      1330       1340       1350       1360       1370       1380 
FRGKRSTEHS YKEDNKEPSS LLNQSVNTTC NTEQPKNLPH VNDFKEFVLD MQKTITGLRK 

      1390       1400       1410       1420       1430       1440 
QIKKLESRLS NTDCTDETGE SHSTKEKWNK DACTKCECYN GHITCFVKSC PPVNCSRPQR 

      1450 
IEGVCCPVCT DDKIQST

« Hide

References

« Hide 'large scale' references
[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.
[2]"Xenopus tropicalis peroxidasin gene is expressed within the developing neural tube and pronephric kidney."
Tindall A.J., Pownall M.E., Morris I.D., Isaacs H.V.
Dev. Dyn. 232:377-384(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION, DEVELOPMENTAL STAGE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC135155 mRNA. Translation: AAI35156.1.
BK005589 Genomic DNA. Translation: DAA05635.1. Different initiation.
RefSeqNP_001076815.1. NM_001083346.1.
UniGeneStr.25013.

3D structure databases

ProteinModelPortalA4IGL7.
ModBaseSearch...

Protein family/group databases

MEROPSI43.001.
PeroxiBase4051. XtPxd.

Proteomic databases

PRIDEA4IGL7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID493201.

Organism-specific databases

XenbaseXB-GENE-923300. pxdn.

Phylogenomic databases

eggNOGNOG295125.
HOVERGENHBG108312.

Family and domain databases

Gene3D1.10.640.10. 2 hits.
2.60.40.10. 4 hits.
InterProIPR000483. Cys-rich_flank_reg_C.
IPR010255. Haem_peroxidase.
IPR002007. Haem_peroxidase_animal.
IPR019791. Haem_peroxidase_animal_subgr.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
IPR001007. VWF_C.
[Graphical view]
PfamPF03098. An_peroxidase. 1 hit.
PF07679. I-set. 4 hits.
PF00560. LRR_1. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view]
PRINTSPR00457. ANPEROXIDASE.
SMARTSM00408. IGc2. 4 hits.
SM00369. LRR_TYP. 4 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMSSF48113. Peroxidase_super. 1 hit.
PROSITEPS50835. IG_LIKE. 4 hits.
PS51450. LRR. 5 hits.
PS00435. PEROXIDASE_1. False negative.
PS00436. PEROXIDASE_2. False negative.
PS50292. PEROXIDASE_3. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePXDN_XENTR
AccessionPrimary (citable) accession number: A4IGL7
Secondary accession number(s): Q5HZ61
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 1, 2007
Last modified: April 3, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents