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A4IGL7

- PXDN_XENTR

UniProt

A4IGL7 - PXDN_XENTR

Protein

Peroxidasin

Gene

pxdn

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (01 May 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    2 phenolic donor + H2O2 = 2 phenoxyl radical of the donor + 2 H2O.

    Cofactori

    Binds 1 calcium ion per subunit.By similarity
    Binds 1 heme B (iron-protoporphyrin IX) group covalently per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei815 – 8151Heme (covalent; via 2 links)By similarity
    Active sitei816 – 8161Proton acceptorPROSITE-ProRule annotation
    Metal bindingi817 – 8171CalciumPROSITE-ProRule annotation
    Metal bindingi896 – 8961CalciumPROSITE-ProRule annotation
    Metal bindingi898 – 8981Calcium; via carbonyl oxygenPROSITE-ProRule annotation
    Metal bindingi900 – 9001CalciumPROSITE-ProRule annotation
    Metal bindingi902 – 9021CalciumPROSITE-ProRule annotation
    Sitei966 – 9661Transition state stabilizerPROSITE-ProRule annotation
    Binding sitei969 – 9691Heme (covalent; via 2 links)By similarity
    Metal bindingi1063 – 10631Iron (heme axial ligand)PROSITE-ProRule annotation

    GO - Molecular functioni

    1. heme binding Source: InterPro
    2. metal ion binding Source: UniProtKB-KW
    3. peroxidase activity Source: UniProtKB-KW

    GO - Biological processi

    1. hydrogen peroxide catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase, Peroxidase

    Keywords - Biological processi

    Hydrogen peroxide

    Keywords - Ligandi

    Calcium, Heme, Iron, Metal-binding

    Protein family/group databases

    MEROPSiI43.001.
    PeroxiBasei4051. XtPxd.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peroxidasin (EC:1.11.1.7)
    Gene namesi
    Name:pxdn
    Synonyms:pxn
    OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
    Taxonomic identifieri8364 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
    ProteomesiUP000008143: Unplaced

    Organism-specific databases

    XenbaseiXB-GENE-923300. pxdn.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 14571432PeroxidasinPRO_0000319621Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi257 ↔ 307By similarity
    Disulfide bondi353 ↔ 402By similarity
    Disulfide bondi444 ↔ 492By similarity
    Disulfide bondi536 ↔ 584By similarity
    Glycosylationi630 – 6301N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi689 – 6891N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi709 – 7091N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi721 – 7211N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi722 ↔ 738By similarity
    Disulfide bondi836 ↔ 846By similarity
    Disulfide bondi840 ↔ 864By similarity
    Disulfide bondi948 ↔ 959By similarity
    Disulfide bondi1166 ↔ 1223By similarity
    Glycosylationi1167 – 11671N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1264 ↔ 1290By similarity
    Glycosylationi1269 – 12691N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1343 – 13431N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1347 – 13471N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1434 – 14341N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiA4IGL7.

    Expressioni

    Developmental stagei

    Maternal expression is localized to the animal hemisphere where it persists through early cleavage stages. Initial zygotic expression is detected in the developing neural tube and becomes localized to the hindbrain and midbrain. Expressed in the primordium of the pronephric kidney and expression persists in the pronephric tubules and duct throughout development.1 Publication

    Interactioni

    Protein-protein interaction databases

    STRINGi8364.ENSXETP00000015184.

    Structurei

    3D structure databases

    ProteinModelPortaliA4IGL7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini26 – 5227LRRNTAdd
    BLAST
    Repeati53 – 7422LRR 1Add
    BLAST
    Repeati77 – 9822LRR 2Add
    BLAST
    Repeati101 – 12222LRR 3Add
    BLAST
    Repeati125 – 14622LRR 4Add
    BLAST
    Repeati149 – 17022LRR 5Add
    BLAST
    Domaini182 – 23554LRRCTAdd
    BLAST
    Domaini236 – 32489Ig-like C2-type 1Add
    BLAST
    Domaini332 – 41887Ig-like C2-type 2Add
    BLAST
    Domaini423 – 51088Ig-like C2-type 3Add
    BLAST
    Domaini515 – 60086Ig-like C2-type 4Add
    BLAST
    Domaini1392 – 145059VWFCPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peroxidase family. XPO subfamily.PROSITE-ProRule annotation
    Contains 5 LRR (leucine-rich) repeats.Curated
    Contains 1 LRRCT domain.Curated
    Contains 1 LRRNT domain.Curated
    Contains 1 VWFC domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG295125.
    HOVERGENiHBG108312.

    Family and domain databases

    Gene3Di1.10.640.10. 2 hits.
    2.60.40.10. 4 hits.
    InterProiIPR000483. Cys-rich_flank_reg_C.
    IPR010255. Haem_peroxidase.
    IPR019791. Haem_peroxidase_animal.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003598. Ig_sub2.
    IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000372. LRR-contain_N.
    IPR001007. VWF_C.
    [Graphical view]
    PfamiPF03098. An_peroxidase. 1 hit.
    PF07679. I-set. 4 hits.
    PF00560. LRR_1. 1 hit.
    PF13855. LRR_8. 1 hit.
    PF00093. VWC. 1 hit.
    [Graphical view]
    PRINTSiPR00457. ANPEROXIDASE.
    SMARTiSM00408. IGc2. 4 hits.
    SM00369. LRR_TYP. 4 hits.
    SM00082. LRRCT. 1 hit.
    SM00013. LRRNT. 1 hit.
    SM00214. VWC. 1 hit.
    [Graphical view]
    SUPFAMiSSF48113. SSF48113. 1 hit.
    PROSITEiPS50835. IG_LIKE. 4 hits.
    PS51450. LRR. 5 hits.
    PS50292. PEROXIDASE_3. 1 hit.
    PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A4IGL7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGAGSWLYL TAGLLVVALP QLSHSCPSRC LCFRTTVRCM HLMLESVPAV     50
    PPHTTILDLR FNRIKDIQTG AFKHLKNLNT LLLNNNQIKR IPSEAFKDLE 100
    NLKYLYLYKN EIQSIDRQAF KGLASLEQLY LHFNQIETLE PESFNYLPKL 150
    ERLFLHNNRI THLVPGTFSQ LESMKRLRLD SNALHCDCEI LWLADLLKIY 200
    SESGNAQAAA TCEYPRRLQG RSVSTITPSE LNCERPRITS EPQDVDVTFG 250
    NTVYFTCRAE GNPKPEIIWL RNNNELSMKD DSRLNLLNDG TLMIQNTKET 300
    DQGIYQCMAK NVAGEVKTHE VTLRYYGTPA TPTFVIQPQN TEVLVGESVT 350
    LECSATGQPH PRVTWTRGDR TPLPSDPRIN ITPSGGLYIQ NVNQDDAGEY 400
    TCFATNSVET IHSTAYIIVQ AVPQFTVVPQ DRNVFEGHTV DFHCEAQGNP 450
    KPVIAWTKGG NQLSVDRRHQ VLSSGTLRIL RVALHDQGQY ECQAVNIVGS 500
    KSTAAQLIVQ TRVTPVFATV PNDMTVEVGT DVQIPCSSQG DPLPIITWNK 550
    DGIQVTESGK FHISPHGYLA IRDAGLADQG RYECVARNPI GYSSVSMVLS 600
    VLVPEVSRTG DPFVATSIIE AIATVDRAIN STRTHLFDSR PRSPGDLLAL 650
    FRYPRDPYTV EQARAAEIFE RTLQLIQDHV QSGLMVDLNG TSYHYNDLVS 700
    PQYLNMIANL SGCATHRRIN NCSNMCFHQK YRTHDGTCNN LQHPMWGASL 750
    TAFERLLKSV YENGFNLPRG ISGRIYNGFP LPLPRLVSTT LIGTHTITPD 800
    EQFTHMLMQW GQFLDHDLDS TVVALSQARF SDGQDCSVVC TNDAPCFPIM 850
    VPPNDPRVRN NARCMSMVRS SPVCGSGMTS LLMNSVYPRE QMNQLTSYID 900
    ASNVYGSSDH ESNEIRDSAS HRGLLKQGIV QRSGKPLLPF ATGPPTECMR 950
    DENESPIPCF LAGDHRANEQ LGLTSMHTLW FREHNRIATE LLRLNPHWDG 1000
    DTIYHETRKI VGAQMQHITY SHWLPKIFGD VGMKMLGEYK SYDPNVNAGI 1050
    LNEFATAAFR FGHTLINPIL YRLDEKFEPI PQGHVPLHRA FFSPFRIVNE 1100
    GGIDPLLRGL IGVAAKMRVT SQLLNTELTE KLFSMAHAVA LDLAALNVQR 1150
    GRDHGIPPYH DFRVFCNLST VQTFDDLRNE IKNPDVREKL KRLYGSPLNI 1200
    DLFPALMVED LIPGSRLGPT LMCLLTTQFR NIRDGDRFWY ENPGVFTAAQ 1250
    LTQIKQTSLA RVLCDNGDNI TKVQHDLFRV AEFPHGYVSC KNIAKMDLRV 1300
    WQDCCEDCRT RGQFSTFSNH FRGKRSTEHS YKEDNKEPSS LLNQSVNTTC 1350
    NTEQPKNLPH VNDFKEFVLD MQKTITGLRK QIKKLESRLS NTDCTDETGE 1400
    SHSTKEKWNK DACTKCECYN GHITCFVKSC PPVNCSRPQR IEGVCCPVCT 1450
    DDKIQST 1457
    Length:1,457
    Mass (Da):163,914
    Last modified:May 1, 2007 - v1
    Checksum:i902697AA1C02311A
    GO

    Sequence cautioni

    The sequence DAA05635.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC135155 mRNA. Translation: AAI35156.1.
    BK005589 Genomic DNA. Translation: DAA05635.1. Different initiation.
    RefSeqiNP_001076815.1. NM_001083346.1.
    UniGeneiStr.25013.

    Genome annotation databases

    GeneIDi493201.
    KEGGixtr:493201.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC135155 mRNA. Translation: AAI35156.1 .
    BK005589 Genomic DNA. Translation: DAA05635.1 . Different initiation.
    RefSeqi NP_001076815.1. NM_001083346.1.
    UniGenei Str.25013.

    3D structure databases

    ProteinModelPortali A4IGL7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 8364.ENSXETP00000015184.

    Protein family/group databases

    MEROPSi I43.001.
    PeroxiBasei 4051. XtPxd.

    Proteomic databases

    PRIDEi A4IGL7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 493201.
    KEGGi xtr:493201.

    Organism-specific databases

    CTDi 7837.
    Xenbasei XB-GENE-923300. pxdn.

    Phylogenomic databases

    eggNOGi NOG295125.
    HOVERGENi HBG108312.

    Family and domain databases

    Gene3Di 1.10.640.10. 2 hits.
    2.60.40.10. 4 hits.
    InterProi IPR000483. Cys-rich_flank_reg_C.
    IPR010255. Haem_peroxidase.
    IPR019791. Haem_peroxidase_animal.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003598. Ig_sub2.
    IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000372. LRR-contain_N.
    IPR001007. VWF_C.
    [Graphical view ]
    Pfami PF03098. An_peroxidase. 1 hit.
    PF07679. I-set. 4 hits.
    PF00560. LRR_1. 1 hit.
    PF13855. LRR_8. 1 hit.
    PF00093. VWC. 1 hit.
    [Graphical view ]
    PRINTSi PR00457. ANPEROXIDASE.
    SMARTi SM00408. IGc2. 4 hits.
    SM00369. LRR_TYP. 4 hits.
    SM00082. LRRCT. 1 hit.
    SM00013. LRRNT. 1 hit.
    SM00214. VWC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48113. SSF48113. 1 hit.
    PROSITEi PS50835. IG_LIKE. 4 hits.
    PS51450. LRR. 5 hits.
    PS50292. PEROXIDASE_3. 1 hit.
    PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.
    2. "Xenopus tropicalis peroxidasin gene is expressed within the developing neural tube and pronephric kidney."
      Tindall A.J., Pownall M.E., Morris I.D., Isaacs H.V.
      Dev. Dyn. 232:377-384(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiPXDN_XENTR
    AccessioniPrimary (citable) accession number: A4IGL7
    Secondary accession number(s): Q5HZ61
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: May 1, 2007
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3