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Protein

Lysosome-associated membrane glycoprotein 5

Gene

lamp5

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosome-associated membrane glycoprotein 5
Alternative name(s):
Lysosome-associated membrane protein 5
Short name:
LAMP-5
Gene namesi
Name:lamp5
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-941198. lamp5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini28 – 231204ExtracellularSequence AnalysisAdd
BLAST
Transmembranei232 – 25221HelicalSequence AnalysisAdd
BLAST
Topological domaini253 – 27624CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cytoplasmic vesicle membrane Source: UniProtKB
  2. dendrite Source: UniProtKB-SubCell
  3. dendrite membrane Source: UniProtKB
  4. early endosome membrane Source: UniProtKB
  5. endoplasmic reticulum-Golgi intermediate compartment membrane Source: UniProtKB
  6. endosome membrane Source: UniProtKB
  7. growth cone membrane Source: UniProtKB
  8. integral component of membrane Source: UniProtKB-KW
  9. plasma membrane Source: UniProtKB
  10. recycling endosome membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasmic vesicle, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence AnalysisAdd
BLAST
Chaini28 – 276249Lysosome-associated membrane glycoprotein 5PRO_0000360416Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi33 – 331N-linked (GlcNAc...)Sequence Analysis
Glycosylationi51 – 511N-linked (GlcNAc...)Sequence Analysis
Glycosylationi100 – 1001N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Expressioni

Gene expression databases

BgeeiA4IGL3.

Family & Domainsi

Sequence similaritiesi

Belongs to the LAMP family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG41798.
GeneTreeiENSGT00390000012584.
HOGENOMiHOG000231912.
HOVERGENiHBG051186.
InParanoidiA4IGL3.
OMAiCPVDERE.
OrthoDBiEOG7DRJ3S.
TreeFamiTF330776.

Family and domain databases

InterProiIPR002000. Lysosome-assoc_membr_glycop.
[Graphical view]
PANTHERiPTHR11506. PTHR11506. 1 hit.
PfamiPF01299. Lamp. 1 hit.
[Graphical view]
PROSITEiPS00310. LAMP_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A4IGL3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYRACTSAL RMPVLLLLLC TFSCNLAEQE VENLSGLSSN PDKNIFAIRE
60 70 80 90 100
NGTTCLMAEF SARILVPYEV PSSNEVDWDL EEASIQLPRD TEIRGKCWNN
110 120 130 140 150
ESELHLSWLD KAYTLKLFFS KEGQDASKSR SWKMSKIQFL YDPSEHTIFK
160 170 180 190 200
SGARPGRHTA NSHHLSLMVT PAGMSYECEA TQRISLTSTD HQKIVVLYLS
210 220 230 240 250
EVHLQPFDIK SDFVYSEEYK CPTDQRKQLE ETLPLILGLT LGVAILIIVA
260 270
VYHIHHKMTA NQVQIPRDRS LYKHMG
Length:276
Mass (Da):31,485
Last modified:May 1, 2007 - v1
Checksum:i8D0D7B4E01A55AE4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC135151 mRNA. Translation: AAI35152.1.
RefSeqiNP_001090781.1. NM_001097312.1.
UniGeneiStr.12939.

Genome annotation databases

EnsembliENSXETT00000033005; ENSXETP00000033005; ENSXETG00000015086.
GeneIDi100037871.
KEGGixtr:100037871.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC135151 mRNA. Translation: AAI35152.1.
RefSeqiNP_001090781.1. NM_001097312.1.
UniGeneiStr.12939.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSXETT00000033005; ENSXETP00000033005; ENSXETG00000015086.
GeneIDi100037871.
KEGGixtr:100037871.

Organism-specific databases

CTDi24141.
XenbaseiXB-GENE-941198. lamp5.

Phylogenomic databases

eggNOGiNOG41798.
GeneTreeiENSGT00390000012584.
HOGENOMiHOG000231912.
HOVERGENiHBG051186.
InParanoidiA4IGL3.
OMAiCPVDERE.
OrthoDBiEOG7DRJ3S.
TreeFamiTF330776.

Gene expression databases

BgeeiA4IGL3.

Family and domain databases

InterProiIPR002000. Lysosome-assoc_membr_glycop.
[Graphical view]
PANTHERiPTHR11506. PTHR11506. 1 hit.
PfamiPF01299. Lamp. 1 hit.
[Graphical view]
PROSITEiPS00310. LAMP_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiLAMP5_XENTR
AccessioniPrimary (citable) accession number: A4IGL3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: May 1, 2007
Last modified: January 7, 2015
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.