Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A4IFW2

- PTPRF_DANRE

UniProt

A4IFW2 - PTPRF_DANRE

Protein

Receptor-type tyrosine-protein phosphatase F

Gene

ptprf

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (01 May 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) By similarity.By similarity
    The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei1518 – 15181SubstrateBy similarity
    Active sitei1550 – 15501Phosphocysteine intermediateBy similarity
    Binding sitei1594 – 15941SubstrateBy similarity
    Active sitei1841 – 18411Phosphocysteine intermediateBy similarity

    GO - Molecular functioni

    1. heparin binding Source: UniProtKB-KW
    2. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW
    2. sensory neuron axon guidance Source: ZFIN

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase, Receptor

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Heparin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Receptor-type tyrosine-protein phosphatase F (EC:3.1.3.48)
    Gene namesi
    Name:ptprf
    ORF Names:si:dkey-21k10.1
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 2

    Organism-specific databases

    ZFINiZDB-GENE-060503-530. ptprfb.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3131Sequence AnalysisAdd
    BLAST
    Chaini32 – 19091878Receptor-type tyrosine-protein phosphatase FPRO_0000370194Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi56 ↔ 109PROSITE-ProRule annotation
    Glycosylationi119 – 1191N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi158 ↔ 208PROSITE-ProRule annotation
    Glycosylationi251 – 2511N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi254 ↔ 299PROSITE-ProRule annotation
    Glycosylationi296 – 2961N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi721 – 7211N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi963 – 9631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi966 – 9661N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiA4IFW2.

    Expressioni

    Gene expression databases

    BgeeiA4IFW2.

    Interactioni

    Protein-protein interaction databases

    STRINGi7955.ENSDARP00000077749.

    Structurei

    3D structure databases

    ProteinModelPortaliA4IFW2.
    SMRiA4IFW2. Positions 320-416, 597-716, 821-913, 918-1008, 1336-1904.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini32 – 12661235ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1288 – 1909622CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1267 – 128721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini35 – 12591Ig-like C2-type 1Add
    BLAST
    Domaini137 – 22589Ig-like C2-type 2Add
    BLAST
    Domaini233 – 31583Ig-like C2-type 3Add
    BLAST
    Domaini322 – 41291Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini417 – 51195Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini515 – 60490Fibronectin type-III 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini609 – 70698Fibronectin type-III 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini711 – 819109Fibronectin type-III 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini820 – 91495Fibronectin type-III 6PROSITE-ProRule annotationAdd
    BLAST
    Domaini918 – 101396Fibronectin type-III 7PROSITE-ProRule annotationAdd
    BLAST
    Domaini1014 – 109885Fibronectin type-III 8PROSITE-ProRule annotationAdd
    BLAST
    Domaini1354 – 1609256Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini1641 – 1900260Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni68 – 7710Heparin-bindingBy similarity
    Regioni1550 – 15567Substrate bindingBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1169 – 11735Poly-Arg
    Compositional biasi1277 – 12848Poly-Ile

    Sequence similaritiesi

    Contains 8 fibronectin type-III domains.PROSITE-ProRule annotation
    Contains 2 tyrosine-protein phosphatase domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5599.
    GeneTreeiENSGT00590000082937.
    HOGENOMiHOG000010250.
    InParanoidiA4IFW2.
    KOiK05695.
    OMAiVFTPTIE.
    OrthoDBiEOG7M98FB.
    PhylomeDBiA4IFW2.
    TreeFamiTF312900.

    Family and domain databases

    Gene3Di2.60.40.10. 11 hits.
    3.90.190.10. 2 hits.
    InterProiIPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view]
    PfamiPF00041. fn3. 7 hits.
    PF07679. I-set. 3 hits.
    PF00102. Y_phosphatase. 2 hits.
    [Graphical view]
    PRINTSiPR00700. PRTYPHPHTASE.
    SMARTiSM00060. FN3. 8 hits.
    SM00409. IG. 1 hit.
    SM00408. IGc2. 2 hits.
    SM00194. PTPc. 2 hits.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 5 hits.
    SSF52799. SSF52799. 2 hits.
    PROSITEiPS50853. FN3. 8 hits.
    PS50835. IG_LIKE. 3 hits.
    PS00383. TYR_PHOSPHATASE_1. 2 hits.
    PS50056. TYR_PHOSPHATASE_2. 2 hits.
    PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A4IFW2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVPNTCTSVP LLPVGLPLLL LLSCIQFSSQ ADSLPNFVRS PEDQTGISGG     50
    VASFVCQAAG EPKPRITWMK KGKKVSSQRF EVIEFDDGSG SVLRIQPLRT 100
    HRDEAIYECT ATNSLGEINT SAKLTVLEEN QIPHGFPTID MGPQLKVVER 150
    TRTTTMLCAA SGNPDPEITW FKDFLPVDIN GNGRIKQLRS GALQIENSEE 200
    SDQGKYECVA TNSAGTRYSA PANLYVRVRR VPPRFSIPPT NHEVMPGGSV 250
    NLTCVAVGAP MPYVKWMTGE VELTKDEEMP VGRNVLELTN IRQSTNYTCV 300
    AISSLGMIEA TAQVSVKALP KPPTSLTVTE TTATSVTLTW DSGNPEPVSY 350
    YIIQYRAKTS DTNFQEVDGV ATTRYSIGGL SPYSEYEFRV MAVNNIGRGP 400
    PSEPVETRTG EQAPSSPPLH VQARMLSAST MLVQWEPPEE PNGQIRGYRI 450
    YYTSDLDAPL SAWQKHNTDD SRLTTISSLT TGITYSLRVL GFTSVGDGPP 500
    SDVLQVKTQQ GVPAQPSSFE AEAELDTRIL LTWLWPVQDP IIKYELQYWE 550
    ADSDNKIHVT FDPAGSYAVE GLKPDTLYKF SLAARSEMGQ GVFTHPIEAR 600
    TAQSAPSAPP QDVHLLSLSS TSIKVSWVAP PAASRHGAIV RYTVSYQAVN 650
    GEDTERHEVP DIGADASSCV LEGLEKWTEY QVWVRAHTDV GPGPESTAVR 700
    IRTNEDVPGA PPRKLEVEAL NSTAIRVTWK PPLSGKQHGQ IRGYQVIYSR 750
    LENGEPRGHP NIMDVALPEA QWKIEESTEY EAVIAGLASE TSYSVTVAAY 800
    TTKGDGARSK AKVVTTTGAV PGKPTMIIST TVGNTALIQW QPPKDMVGEL 850
    MGYRLRYKRL EEENYEIREF SRTDDHHTVT DLHKGATYSF HLSARNRAGL 900
    GEEYVKDIGT PEDVPSGFPL NLQVVGLTTS TTRLTWEPPA LSERNGRIIH 950
    YIVVYRDINS KQNSTNRTSD TQMTIQGLRP DTTYDIRVQA FTSKGGGPIS 1000
    PSIQSRTMST SPAFATSFGV KAVMKTSVLL TWEVPENYKS QVPFKILYNQ 1050
    QSVEVQGNLK RKLITRLQPD TDYSFVLMSR GNSAGGLQQQ VSIRTAPDLF 1100
    KTKPVLYTAD QTNNGKLTIN LPKVPTSAPV RCYYIVVVPV SQTSSRQWIN 1150
    PDEMELDELL ESSEGAHLRR RRRHTDTVRP YIAAKLSTLP ETFTLGDELD 1200
    YSGFINRPLP NNQHFQCFVM AELKDQYPVT ANEKQRTFSA SPYSDPIIVQ 1250
    GENQMQRSVD QPEMLWVMGP VLAVVLIIII VIAILLFKRK RASPLPKDDH 1300
    SGGVKDCLLA SSSDPVEMRR LNYQTPGMRE HPPISVSELA DHIERLKAND 1350
    ALRFSQEYES IDPGQQFTWE NSNLEVNKPK NRYANVIAYD HSRVVLTPVD 1400
    GVPGSDYINS NYIDGYRKQN AYIATQGPLP ETLSDFWRMI WEQRASTIVM 1450
    MTRLEEKSRV KCDQYWPIRG TETYGMIQVT MLDAVELATY SVRTFALYKN 1500
    GSSEKREVRQ FQFMAWPDHG VPEYPTPILA FLRRVKACNP PDAGPMVVHC 1550
    SAGVGRTGCF IVIDAMLERM KHEKTVDIYG HVTCMRSQRN YMVQTEDQYI 1600
    FIHEALLEAA TCGNTEVPAR NLYAHIQKLT QPSAGETVTA MELEFKRLAN 1650
    SKAHTSRFIS ANLPCNKFKN RLVNIMPFES TRVCLQPIRG VEGSDYINAS 1700
    CIDGYRQQKA YIATQGPLAE TTEDFWRMLW EHNSTIVVML TKLREMGREK 1750
    CHQYWPAERS ARYQYFVVDP MAEYNMPQYI LREFKVTDAR DGQSRTIRQF 1800
    QFTDWPEQGV PKTGEGFIDF IGQVHKTKEQ FGQDGPITVH CSAGVGRTGV 1850
    FITLSIVLER MRYEGVVDLF QTVKTLRTQR PAMVQTEDQY QLCYRAALEY 1900
    LGSFDHYAT 1909
    Length:1,909
    Mass (Da):213,454
    Last modified:May 1, 2007 - v1
    Checksum:i2568D6434864E596
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX663493, BX248089 Genomic DNA. Translation: CAN88403.1.
    BX248089, BX663493 Genomic DNA. Translation: CAQ13596.1.
    BC134804 mRNA. Translation: AAI34805.1.
    RefSeqiNP_001077045.1. NM_001083576.1.
    UniGeneiDr.12854.

    Genome annotation databases

    EnsembliENSDART00000083314; ENSDARP00000077749; ENSDARG00000005754.
    GeneIDi799867.
    KEGGidre:799867.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX663493 , BX248089 Genomic DNA. Translation: CAN88403.1 .
    BX248089 , BX663493 Genomic DNA. Translation: CAQ13596.1 .
    BC134804 mRNA. Translation: AAI34805.1 .
    RefSeqi NP_001077045.1. NM_001083576.1.
    UniGenei Dr.12854.

    3D structure databases

    ProteinModelPortali A4IFW2.
    SMRi A4IFW2. Positions 320-416, 597-716, 821-913, 918-1008, 1336-1904.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7955.ENSDARP00000077749.

    Proteomic databases

    PRIDEi A4IFW2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000083314 ; ENSDARP00000077749 ; ENSDARG00000005754 .
    GeneIDi 799867.
    KEGGi dre:799867.

    Organism-specific databases

    CTDi 799867.
    ZFINi ZDB-GENE-060503-530. ptprfb.

    Phylogenomic databases

    eggNOGi COG5599.
    GeneTreei ENSGT00590000082937.
    HOGENOMi HOG000010250.
    InParanoidi A4IFW2.
    KOi K05695.
    OMAi VFTPTIE.
    OrthoDBi EOG7M98FB.
    PhylomeDBi A4IFW2.
    TreeFami TF312900.

    Miscellaneous databases

    NextBioi 20934001.
    PROi A4IFW2.

    Gene expression databases

    Bgeei A4IFW2.

    Family and domain databases

    Gene3Di 2.60.40.10. 11 hits.
    3.90.190.10. 2 hits.
    InterProi IPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view ]
    Pfami PF00041. fn3. 7 hits.
    PF07679. I-set. 3 hits.
    PF00102. Y_phosphatase. 2 hits.
    [Graphical view ]
    PRINTSi PR00700. PRTYPHPHTASE.
    SMARTi SM00060. FN3. 8 hits.
    SM00409. IG. 1 hit.
    SM00408. IGc2. 2 hits.
    SM00194. PTPc. 2 hits.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 5 hits.
    SSF52799. SSF52799. 2 hits.
    PROSITEi PS50853. FN3. 8 hits.
    PS50835. IG_LIKE. 3 hits.
    PS00383. TYR_PHOSPHATASE_1. 2 hits.
    PS50056. TYR_PHOSPHATASE_2. 2 hits.
    PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The zebrafish reference genome sequence and its relationship to the human genome."
      Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
      , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
      Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tuebingen.
    2. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiPTPRF_DANRE
    AccessioniPrimary (citable) accession number: A4IFW2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: May 1, 2007
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3