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Protein

Receptor-type tyrosine-protein phosphatase F

Gene

ptprf

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) (By similarity).By similarity
The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei1518SubstrateBy similarity1
Active sitei1550Phosphocysteine intermediateBy similarity1
Binding sitei1594SubstrateBy similarity1
Active sitei1841Phosphocysteine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: UniProtKB-KW
  • sensory neuron axon guidance Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase, Receptor

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Heparin-binding

Enzyme and pathway databases

ReactomeiR-DRE-8849932. SALM protein interactions at the synapses.

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase F (EC:3.1.3.48)
Gene namesi
Name:ptprf
ORF Names:si:dkey-21k10.1
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 2

Organism-specific databases

ZFINiZDB-GENE-060503-530. ptprfb.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini32 – 1266ExtracellularSequence analysisAdd BLAST1235
Transmembranei1267 – 1287HelicalSequence analysisAdd BLAST21
Topological domaini1288 – 1909CytoplasmicSequence analysisAdd BLAST622

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_000037019432 – 1909Receptor-type tyrosine-protein phosphatase FAdd BLAST1878

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi56 ↔ 109PROSITE-ProRule annotation
Glycosylationi119N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi158 ↔ 208PROSITE-ProRule annotation
Glycosylationi251N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi254 ↔ 299PROSITE-ProRule annotation
Glycosylationi296N-linked (GlcNAc...)Sequence analysis1
Glycosylationi721N-linked (GlcNAc...)Sequence analysis1
Glycosylationi963N-linked (GlcNAc...)Sequence analysis1
Glycosylationi966N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA4IFW2.
PeptideAtlasiA4IFW2.
PRIDEiA4IFW2.

Expressioni

Gene expression databases

BgeeiENSDARG00000005754.
ExpressionAtlasiA4IFW2. differential.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000077749.

Structurei

3D structure databases

ProteinModelPortaliA4IFW2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 125Ig-like C2-type 1Add BLAST91
Domaini137 – 225Ig-like C2-type 2Add BLAST89
Domaini233 – 315Ig-like C2-type 3Add BLAST83
Domaini322 – 412Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST91
Domaini417 – 511Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST95
Domaini515 – 604Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST90
Domaini609 – 706Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST98
Domaini711 – 819Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST109
Domaini820 – 914Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST95
Domaini918 – 1013Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST96
Domaini1014 – 1098Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST85
Domaini1354 – 1609Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd BLAST256
Domaini1641 – 1900Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd BLAST260

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni68 – 77Heparin-bindingBy similarity10
Regioni1550 – 1556Substrate bindingBy similarity7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1169 – 1173Poly-Arg5
Compositional biasi1277 – 1284Poly-Ile8

Sequence similaritiesi

Contains 8 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 2 tyrosine-protein phosphatase domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4228. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00760000118900.
HOGENOMiHOG000010250.
InParanoidiA4IFW2.
KOiK05695.
OMAiMLTPRWS.
OrthoDBiEOG091G11WG.
PhylomeDBiA4IFW2.
TreeFamiTF312900.

Family and domain databases

CDDicd00063. FN3. 8 hits.
Gene3Di2.60.40.10. 11 hits.
3.90.190.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00041. fn3. 7 hits.
PF07679. I-set. 3 hits.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 8 hits.
SM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
SM00194. PTPc. 2 hits.
SM00404. PTPc_motif. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF49265. SSF49265. 5 hits.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 8 hits.
PS50835. IG_LIKE. 3 hits.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A4IFW2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPNTCTSVP LLPVGLPLLL LLSCIQFSSQ ADSLPNFVRS PEDQTGISGG
60 70 80 90 100
VASFVCQAAG EPKPRITWMK KGKKVSSQRF EVIEFDDGSG SVLRIQPLRT
110 120 130 140 150
HRDEAIYECT ATNSLGEINT SAKLTVLEEN QIPHGFPTID MGPQLKVVER
160 170 180 190 200
TRTTTMLCAA SGNPDPEITW FKDFLPVDIN GNGRIKQLRS GALQIENSEE
210 220 230 240 250
SDQGKYECVA TNSAGTRYSA PANLYVRVRR VPPRFSIPPT NHEVMPGGSV
260 270 280 290 300
NLTCVAVGAP MPYVKWMTGE VELTKDEEMP VGRNVLELTN IRQSTNYTCV
310 320 330 340 350
AISSLGMIEA TAQVSVKALP KPPTSLTVTE TTATSVTLTW DSGNPEPVSY
360 370 380 390 400
YIIQYRAKTS DTNFQEVDGV ATTRYSIGGL SPYSEYEFRV MAVNNIGRGP
410 420 430 440 450
PSEPVETRTG EQAPSSPPLH VQARMLSAST MLVQWEPPEE PNGQIRGYRI
460 470 480 490 500
YYTSDLDAPL SAWQKHNTDD SRLTTISSLT TGITYSLRVL GFTSVGDGPP
510 520 530 540 550
SDVLQVKTQQ GVPAQPSSFE AEAELDTRIL LTWLWPVQDP IIKYELQYWE
560 570 580 590 600
ADSDNKIHVT FDPAGSYAVE GLKPDTLYKF SLAARSEMGQ GVFTHPIEAR
610 620 630 640 650
TAQSAPSAPP QDVHLLSLSS TSIKVSWVAP PAASRHGAIV RYTVSYQAVN
660 670 680 690 700
GEDTERHEVP DIGADASSCV LEGLEKWTEY QVWVRAHTDV GPGPESTAVR
710 720 730 740 750
IRTNEDVPGA PPRKLEVEAL NSTAIRVTWK PPLSGKQHGQ IRGYQVIYSR
760 770 780 790 800
LENGEPRGHP NIMDVALPEA QWKIEESTEY EAVIAGLASE TSYSVTVAAY
810 820 830 840 850
TTKGDGARSK AKVVTTTGAV PGKPTMIIST TVGNTALIQW QPPKDMVGEL
860 870 880 890 900
MGYRLRYKRL EEENYEIREF SRTDDHHTVT DLHKGATYSF HLSARNRAGL
910 920 930 940 950
GEEYVKDIGT PEDVPSGFPL NLQVVGLTTS TTRLTWEPPA LSERNGRIIH
960 970 980 990 1000
YIVVYRDINS KQNSTNRTSD TQMTIQGLRP DTTYDIRVQA FTSKGGGPIS
1010 1020 1030 1040 1050
PSIQSRTMST SPAFATSFGV KAVMKTSVLL TWEVPENYKS QVPFKILYNQ
1060 1070 1080 1090 1100
QSVEVQGNLK RKLITRLQPD TDYSFVLMSR GNSAGGLQQQ VSIRTAPDLF
1110 1120 1130 1140 1150
KTKPVLYTAD QTNNGKLTIN LPKVPTSAPV RCYYIVVVPV SQTSSRQWIN
1160 1170 1180 1190 1200
PDEMELDELL ESSEGAHLRR RRRHTDTVRP YIAAKLSTLP ETFTLGDELD
1210 1220 1230 1240 1250
YSGFINRPLP NNQHFQCFVM AELKDQYPVT ANEKQRTFSA SPYSDPIIVQ
1260 1270 1280 1290 1300
GENQMQRSVD QPEMLWVMGP VLAVVLIIII VIAILLFKRK RASPLPKDDH
1310 1320 1330 1340 1350
SGGVKDCLLA SSSDPVEMRR LNYQTPGMRE HPPISVSELA DHIERLKAND
1360 1370 1380 1390 1400
ALRFSQEYES IDPGQQFTWE NSNLEVNKPK NRYANVIAYD HSRVVLTPVD
1410 1420 1430 1440 1450
GVPGSDYINS NYIDGYRKQN AYIATQGPLP ETLSDFWRMI WEQRASTIVM
1460 1470 1480 1490 1500
MTRLEEKSRV KCDQYWPIRG TETYGMIQVT MLDAVELATY SVRTFALYKN
1510 1520 1530 1540 1550
GSSEKREVRQ FQFMAWPDHG VPEYPTPILA FLRRVKACNP PDAGPMVVHC
1560 1570 1580 1590 1600
SAGVGRTGCF IVIDAMLERM KHEKTVDIYG HVTCMRSQRN YMVQTEDQYI
1610 1620 1630 1640 1650
FIHEALLEAA TCGNTEVPAR NLYAHIQKLT QPSAGETVTA MELEFKRLAN
1660 1670 1680 1690 1700
SKAHTSRFIS ANLPCNKFKN RLVNIMPFES TRVCLQPIRG VEGSDYINAS
1710 1720 1730 1740 1750
CIDGYRQQKA YIATQGPLAE TTEDFWRMLW EHNSTIVVML TKLREMGREK
1760 1770 1780 1790 1800
CHQYWPAERS ARYQYFVVDP MAEYNMPQYI LREFKVTDAR DGQSRTIRQF
1810 1820 1830 1840 1850
QFTDWPEQGV PKTGEGFIDF IGQVHKTKEQ FGQDGPITVH CSAGVGRTGV
1860 1870 1880 1890 1900
FITLSIVLER MRYEGVVDLF QTVKTLRTQR PAMVQTEDQY QLCYRAALEY

LGSFDHYAT
Length:1,909
Mass (Da):213,454
Last modified:May 1, 2007 - v1
Checksum:i2568D6434864E596
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX663493, BX248089 Genomic DNA. Translation: CAN88403.1.
BX248089, BX663493 Genomic DNA. Translation: CAQ13596.1.
BC134804 mRNA. Translation: AAI34805.1.
RefSeqiNP_001077045.1. NM_001083576.1.
UniGeneiDr.12854.

Genome annotation databases

EnsembliENSDART00000083314; ENSDARP00000077749; ENSDARG00000005754.
GeneIDi799867.
KEGGidre:799867.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX663493, BX248089 Genomic DNA. Translation: CAN88403.1.
BX248089, BX663493 Genomic DNA. Translation: CAQ13596.1.
BC134804 mRNA. Translation: AAI34805.1.
RefSeqiNP_001077045.1. NM_001083576.1.
UniGeneiDr.12854.

3D structure databases

ProteinModelPortaliA4IFW2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000077749.

Proteomic databases

PaxDbiA4IFW2.
PeptideAtlasiA4IFW2.
PRIDEiA4IFW2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000083314; ENSDARP00000077749; ENSDARG00000005754.
GeneIDi799867.
KEGGidre:799867.

Organism-specific databases

CTDi799867.
ZFINiZDB-GENE-060503-530. ptprfb.

Phylogenomic databases

eggNOGiKOG4228. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00760000118900.
HOGENOMiHOG000010250.
InParanoidiA4IFW2.
KOiK05695.
OMAiMLTPRWS.
OrthoDBiEOG091G11WG.
PhylomeDBiA4IFW2.
TreeFamiTF312900.

Enzyme and pathway databases

ReactomeiR-DRE-8849932. SALM protein interactions at the synapses.

Miscellaneous databases

PROiA4IFW2.

Gene expression databases

BgeeiENSDARG00000005754.
ExpressionAtlasiA4IFW2. differential.

Family and domain databases

CDDicd00063. FN3. 8 hits.
Gene3Di2.60.40.10. 11 hits.
3.90.190.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00041. fn3. 7 hits.
PF07679. I-set. 3 hits.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 8 hits.
SM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
SM00194. PTPc. 2 hits.
SM00404. PTPc_motif. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF49265. SSF49265. 5 hits.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 8 hits.
PS50835. IG_LIKE. 3 hits.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTPRF_DANRE
AccessioniPrimary (citable) accession number: A4IFW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 1, 2007
Last modified: November 30, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.