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A4IFW2

- PTPRF_DANRE

UniProt

A4IFW2 - PTPRF_DANRE

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Protein

Receptor-type tyrosine-protein phosphatase F

Gene

ptprf

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) (By similarity).By similarity
The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1518 – 15181SubstrateBy similarity
Active sitei1550 – 15501Phosphocysteine intermediateBy similarity
Binding sitei1594 – 15941SubstrateBy similarity
Active sitei1841 – 18411Phosphocysteine intermediateBy similarity

GO - Molecular functioni

  1. heparin binding Source: UniProtKB-KW
  2. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. sensory neuron axon guidance Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase, Receptor

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Heparin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase F (EC:3.1.3.48)
Gene namesi
Name:ptprf
ORF Names:si:dkey-21k10.1
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Chromosome 2

Organism-specific databases

ZFINiZDB-GENE-060503-530. ptprfb.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131Sequence AnalysisAdd
BLAST
Chaini32 – 19091878Receptor-type tyrosine-protein phosphatase FPRO_0000370194Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi56 ↔ 109PROSITE-ProRule annotation
Glycosylationi119 – 1191N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi158 ↔ 208PROSITE-ProRule annotation
Glycosylationi251 – 2511N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi254 ↔ 299PROSITE-ProRule annotation
Glycosylationi296 – 2961N-linked (GlcNAc...)Sequence Analysis
Glycosylationi721 – 7211N-linked (GlcNAc...)Sequence Analysis
Glycosylationi963 – 9631N-linked (GlcNAc...)Sequence Analysis
Glycosylationi966 – 9661N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiA4IFW2.

Expressioni

Gene expression databases

BgeeiA4IFW2.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000077749.

Structurei

3D structure databases

ProteinModelPortaliA4IFW2.
SMRiA4IFW2. Positions 320-416, 597-716, 821-913, 918-1008, 1336-1904.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini32 – 12661235ExtracellularSequence AnalysisAdd
BLAST
Topological domaini1288 – 1909622CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1267 – 128721HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 12591Ig-like C2-type 1Add
BLAST
Domaini137 – 22589Ig-like C2-type 2Add
BLAST
Domaini233 – 31583Ig-like C2-type 3Add
BLAST
Domaini322 – 41291Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini417 – 51195Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini515 – 60490Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST
Domaini609 – 70698Fibronectin type-III 4PROSITE-ProRule annotationAdd
BLAST
Domaini711 – 819109Fibronectin type-III 5PROSITE-ProRule annotationAdd
BLAST
Domaini820 – 91495Fibronectin type-III 6PROSITE-ProRule annotationAdd
BLAST
Domaini918 – 101396Fibronectin type-III 7PROSITE-ProRule annotationAdd
BLAST
Domaini1014 – 109885Fibronectin type-III 8PROSITE-ProRule annotationAdd
BLAST
Domaini1354 – 1609256Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd
BLAST
Domaini1641 – 1900260Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni68 – 7710Heparin-bindingBy similarity
Regioni1550 – 15567Substrate bindingBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1169 – 11735Poly-Arg
Compositional biasi1277 – 12848Poly-Ile

Sequence similaritiesi

Contains 8 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 2 tyrosine-protein phosphatase domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5599.
GeneTreeiENSGT00760000118900.
HOGENOMiHOG000010250.
InParanoidiA4IFW2.
KOiK05695.
OMAiVFTPTIE.
OrthoDBiEOG7M98FB.
PhylomeDBiA4IFW2.
TreeFamiTF312900.

Family and domain databases

Gene3Di2.60.40.10. 11 hits.
3.90.190.10. 2 hits.
InterProiIPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00041. fn3. 7 hits.
PF07679. I-set. 3 hits.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 8 hits.
SM00409. IG. 1 hit.
SM00408. IGc2. 2 hits.
SM00194. PTPc. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 5 hits.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 8 hits.
PS50835. IG_LIKE. 3 hits.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A4IFW2-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MVPNTCTSVP LLPVGLPLLL LLSCIQFSSQ ADSLPNFVRS PEDQTGISGG
60 70 80 90 100
VASFVCQAAG EPKPRITWMK KGKKVSSQRF EVIEFDDGSG SVLRIQPLRT
110 120 130 140 150
HRDEAIYECT ATNSLGEINT SAKLTVLEEN QIPHGFPTID MGPQLKVVER
160 170 180 190 200
TRTTTMLCAA SGNPDPEITW FKDFLPVDIN GNGRIKQLRS GALQIENSEE
210 220 230 240 250
SDQGKYECVA TNSAGTRYSA PANLYVRVRR VPPRFSIPPT NHEVMPGGSV
260 270 280 290 300
NLTCVAVGAP MPYVKWMTGE VELTKDEEMP VGRNVLELTN IRQSTNYTCV
310 320 330 340 350
AISSLGMIEA TAQVSVKALP KPPTSLTVTE TTATSVTLTW DSGNPEPVSY
360 370 380 390 400
YIIQYRAKTS DTNFQEVDGV ATTRYSIGGL SPYSEYEFRV MAVNNIGRGP
410 420 430 440 450
PSEPVETRTG EQAPSSPPLH VQARMLSAST MLVQWEPPEE PNGQIRGYRI
460 470 480 490 500
YYTSDLDAPL SAWQKHNTDD SRLTTISSLT TGITYSLRVL GFTSVGDGPP
510 520 530 540 550
SDVLQVKTQQ GVPAQPSSFE AEAELDTRIL LTWLWPVQDP IIKYELQYWE
560 570 580 590 600
ADSDNKIHVT FDPAGSYAVE GLKPDTLYKF SLAARSEMGQ GVFTHPIEAR
610 620 630 640 650
TAQSAPSAPP QDVHLLSLSS TSIKVSWVAP PAASRHGAIV RYTVSYQAVN
660 670 680 690 700
GEDTERHEVP DIGADASSCV LEGLEKWTEY QVWVRAHTDV GPGPESTAVR
710 720 730 740 750
IRTNEDVPGA PPRKLEVEAL NSTAIRVTWK PPLSGKQHGQ IRGYQVIYSR
760 770 780 790 800
LENGEPRGHP NIMDVALPEA QWKIEESTEY EAVIAGLASE TSYSVTVAAY
810 820 830 840 850
TTKGDGARSK AKVVTTTGAV PGKPTMIIST TVGNTALIQW QPPKDMVGEL
860 870 880 890 900
MGYRLRYKRL EEENYEIREF SRTDDHHTVT DLHKGATYSF HLSARNRAGL
910 920 930 940 950
GEEYVKDIGT PEDVPSGFPL NLQVVGLTTS TTRLTWEPPA LSERNGRIIH
960 970 980 990 1000
YIVVYRDINS KQNSTNRTSD TQMTIQGLRP DTTYDIRVQA FTSKGGGPIS
1010 1020 1030 1040 1050
PSIQSRTMST SPAFATSFGV KAVMKTSVLL TWEVPENYKS QVPFKILYNQ
1060 1070 1080 1090 1100
QSVEVQGNLK RKLITRLQPD TDYSFVLMSR GNSAGGLQQQ VSIRTAPDLF
1110 1120 1130 1140 1150
KTKPVLYTAD QTNNGKLTIN LPKVPTSAPV RCYYIVVVPV SQTSSRQWIN
1160 1170 1180 1190 1200
PDEMELDELL ESSEGAHLRR RRRHTDTVRP YIAAKLSTLP ETFTLGDELD
1210 1220 1230 1240 1250
YSGFINRPLP NNQHFQCFVM AELKDQYPVT ANEKQRTFSA SPYSDPIIVQ
1260 1270 1280 1290 1300
GENQMQRSVD QPEMLWVMGP VLAVVLIIII VIAILLFKRK RASPLPKDDH
1310 1320 1330 1340 1350
SGGVKDCLLA SSSDPVEMRR LNYQTPGMRE HPPISVSELA DHIERLKAND
1360 1370 1380 1390 1400
ALRFSQEYES IDPGQQFTWE NSNLEVNKPK NRYANVIAYD HSRVVLTPVD
1410 1420 1430 1440 1450
GVPGSDYINS NYIDGYRKQN AYIATQGPLP ETLSDFWRMI WEQRASTIVM
1460 1470 1480 1490 1500
MTRLEEKSRV KCDQYWPIRG TETYGMIQVT MLDAVELATY SVRTFALYKN
1510 1520 1530 1540 1550
GSSEKREVRQ FQFMAWPDHG VPEYPTPILA FLRRVKACNP PDAGPMVVHC
1560 1570 1580 1590 1600
SAGVGRTGCF IVIDAMLERM KHEKTVDIYG HVTCMRSQRN YMVQTEDQYI
1610 1620 1630 1640 1650
FIHEALLEAA TCGNTEVPAR NLYAHIQKLT QPSAGETVTA MELEFKRLAN
1660 1670 1680 1690 1700
SKAHTSRFIS ANLPCNKFKN RLVNIMPFES TRVCLQPIRG VEGSDYINAS
1710 1720 1730 1740 1750
CIDGYRQQKA YIATQGPLAE TTEDFWRMLW EHNSTIVVML TKLREMGREK
1760 1770 1780 1790 1800
CHQYWPAERS ARYQYFVVDP MAEYNMPQYI LREFKVTDAR DGQSRTIRQF
1810 1820 1830 1840 1850
QFTDWPEQGV PKTGEGFIDF IGQVHKTKEQ FGQDGPITVH CSAGVGRTGV
1860 1870 1880 1890 1900
FITLSIVLER MRYEGVVDLF QTVKTLRTQR PAMVQTEDQY QLCYRAALEY

LGSFDHYAT
Length:1,909
Mass (Da):213,454
Last modified:May 1, 2007 - v1
Checksum:i2568D6434864E596
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX663493, BX248089 Genomic DNA. Translation: CAN88403.1.
BX248089, BX663493 Genomic DNA. Translation: CAQ13596.1.
BC134804 mRNA. Translation: AAI34805.1.
RefSeqiNP_001077045.1. NM_001083576.1.
UniGeneiDr.12854.

Genome annotation databases

EnsembliENSDART00000083314; ENSDARP00000077749; ENSDARG00000005754.
GeneIDi799867.
KEGGidre:799867.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX663493 , BX248089 Genomic DNA. Translation: CAN88403.1 .
BX248089 , BX663493 Genomic DNA. Translation: CAQ13596.1 .
BC134804 mRNA. Translation: AAI34805.1 .
RefSeqi NP_001077045.1. NM_001083576.1.
UniGenei Dr.12854.

3D structure databases

ProteinModelPortali A4IFW2.
SMRi A4IFW2. Positions 320-416, 597-716, 821-913, 918-1008, 1336-1904.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000077749.

Proteomic databases

PRIDEi A4IFW2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSDART00000083314 ; ENSDARP00000077749 ; ENSDARG00000005754 .
GeneIDi 799867.
KEGGi dre:799867.

Organism-specific databases

CTDi 799867.
ZFINi ZDB-GENE-060503-530. ptprfb.

Phylogenomic databases

eggNOGi COG5599.
GeneTreei ENSGT00760000118900.
HOGENOMi HOG000010250.
InParanoidi A4IFW2.
KOi K05695.
OMAi VFTPTIE.
OrthoDBi EOG7M98FB.
PhylomeDBi A4IFW2.
TreeFami TF312900.

Miscellaneous databases

NextBioi 20934001.
PROi A4IFW2.

Gene expression databases

Bgeei A4IFW2.

Family and domain databases

Gene3Di 2.60.40.10. 11 hits.
3.90.190.10. 2 hits.
InterProi IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF00041. fn3. 7 hits.
PF07679. I-set. 3 hits.
PF00102. Y_phosphatase. 2 hits.
[Graphical view ]
PRINTSi PR00700. PRTYPHPHTASE.
SMARTi SM00060. FN3. 8 hits.
SM00409. IG. 1 hit.
SM00408. IGc2. 2 hits.
SM00194. PTPc. 2 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 5 hits.
SSF52799. SSF52799. 2 hits.
PROSITEi PS50853. FN3. 8 hits.
PS50835. IG_LIKE. 3 hits.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tuebingen.
  2. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiPTPRF_DANRE
AccessioniPrimary (citable) accession number: A4IFW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 1, 2007
Last modified: October 29, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3