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A4IFW2 (PTPRF_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Receptor-type tyrosine-protein phosphatase F

EC=3.1.3.48
Gene names
Name:ptprf
ORF Names:si:dkey-21k10.1
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length1909 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) By similarity.

The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one By similarity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Subcellular location

Membrane; Single-pass membrane protein Potential.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.

Contains 8 fibronectin type-III domains.

Contains 3 Ig-like C2-type (immunoglobulin-like) domains.

Contains 2 tyrosine-protein phosphatase domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3131 Potential
Chain32 – 19091878Receptor-type tyrosine-protein phosphatase F
PRO_0000370194

Regions

Topological domain32 – 12661235Extracellular Potential
Transmembrane1267 – 128721Helical; Potential
Topological domain1288 – 1909622Cytoplasmic Potential
Domain35 – 12591Ig-like C2-type 1
Domain137 – 22589Ig-like C2-type 2
Domain233 – 31583Ig-like C2-type 3
Domain322 – 41291Fibronectin type-III 1
Domain417 – 51195Fibronectin type-III 2
Domain515 – 60490Fibronectin type-III 3
Domain609 – 70698Fibronectin type-III 4
Domain711 – 819109Fibronectin type-III 5
Domain820 – 91495Fibronectin type-III 6
Domain918 – 101396Fibronectin type-III 7
Domain1014 – 109885Fibronectin type-III 8
Domain1354 – 1609256Tyrosine-protein phosphatase 1
Domain1641 – 1900260Tyrosine-protein phosphatase 2
Region68 – 7710Heparin-binding By similarity
Region1550 – 15567Substrate binding By similarity
Compositional bias1169 – 11735Poly-Arg
Compositional bias1277 – 12848Poly-Ile

Sites

Active site15501Phosphocysteine intermediate By similarity
Active site18411Phosphocysteine intermediate By similarity
Binding site15181Substrate By similarity
Binding site15941Substrate By similarity

Amino acid modifications

Glycosylation1191N-linked (GlcNAc...) Potential
Glycosylation2511N-linked (GlcNAc...) Potential
Glycosylation2961N-linked (GlcNAc...) Potential
Glycosylation7211N-linked (GlcNAc...) Potential
Glycosylation9631N-linked (GlcNAc...) Potential
Glycosylation9661N-linked (GlcNAc...) Potential
Disulfide bond56 ↔ 109 By similarity
Disulfide bond158 ↔ 208 By similarity
Disulfide bond254 ↔ 299 By similarity

Sequences

Sequence LengthMass (Da)Tools
A4IFW2 [UniParc].

Last modified May 1, 2007. Version 1.
Checksum: 2568D6434864E596

FASTA1,909213,454
        10         20         30         40         50         60 
MVPNTCTSVP LLPVGLPLLL LLSCIQFSSQ ADSLPNFVRS PEDQTGISGG VASFVCQAAG 

        70         80         90        100        110        120 
EPKPRITWMK KGKKVSSQRF EVIEFDDGSG SVLRIQPLRT HRDEAIYECT ATNSLGEINT 

       130        140        150        160        170        180 
SAKLTVLEEN QIPHGFPTID MGPQLKVVER TRTTTMLCAA SGNPDPEITW FKDFLPVDIN 

       190        200        210        220        230        240 
GNGRIKQLRS GALQIENSEE SDQGKYECVA TNSAGTRYSA PANLYVRVRR VPPRFSIPPT 

       250        260        270        280        290        300 
NHEVMPGGSV NLTCVAVGAP MPYVKWMTGE VELTKDEEMP VGRNVLELTN IRQSTNYTCV 

       310        320        330        340        350        360 
AISSLGMIEA TAQVSVKALP KPPTSLTVTE TTATSVTLTW DSGNPEPVSY YIIQYRAKTS 

       370        380        390        400        410        420 
DTNFQEVDGV ATTRYSIGGL SPYSEYEFRV MAVNNIGRGP PSEPVETRTG EQAPSSPPLH 

       430        440        450        460        470        480 
VQARMLSAST MLVQWEPPEE PNGQIRGYRI YYTSDLDAPL SAWQKHNTDD SRLTTISSLT 

       490        500        510        520        530        540 
TGITYSLRVL GFTSVGDGPP SDVLQVKTQQ GVPAQPSSFE AEAELDTRIL LTWLWPVQDP 

       550        560        570        580        590        600 
IIKYELQYWE ADSDNKIHVT FDPAGSYAVE GLKPDTLYKF SLAARSEMGQ GVFTHPIEAR 

       610        620        630        640        650        660 
TAQSAPSAPP QDVHLLSLSS TSIKVSWVAP PAASRHGAIV RYTVSYQAVN GEDTERHEVP 

       670        680        690        700        710        720 
DIGADASSCV LEGLEKWTEY QVWVRAHTDV GPGPESTAVR IRTNEDVPGA PPRKLEVEAL 

       730        740        750        760        770        780 
NSTAIRVTWK PPLSGKQHGQ IRGYQVIYSR LENGEPRGHP NIMDVALPEA QWKIEESTEY 

       790        800        810        820        830        840 
EAVIAGLASE TSYSVTVAAY TTKGDGARSK AKVVTTTGAV PGKPTMIIST TVGNTALIQW 

       850        860        870        880        890        900 
QPPKDMVGEL MGYRLRYKRL EEENYEIREF SRTDDHHTVT DLHKGATYSF HLSARNRAGL 

       910        920        930        940        950        960 
GEEYVKDIGT PEDVPSGFPL NLQVVGLTTS TTRLTWEPPA LSERNGRIIH YIVVYRDINS 

       970        980        990       1000       1010       1020 
KQNSTNRTSD TQMTIQGLRP DTTYDIRVQA FTSKGGGPIS PSIQSRTMST SPAFATSFGV 

      1030       1040       1050       1060       1070       1080 
KAVMKTSVLL TWEVPENYKS QVPFKILYNQ QSVEVQGNLK RKLITRLQPD TDYSFVLMSR 

      1090       1100       1110       1120       1130       1140 
GNSAGGLQQQ VSIRTAPDLF KTKPVLYTAD QTNNGKLTIN LPKVPTSAPV RCYYIVVVPV 

      1150       1160       1170       1180       1190       1200 
SQTSSRQWIN PDEMELDELL ESSEGAHLRR RRRHTDTVRP YIAAKLSTLP ETFTLGDELD 

      1210       1220       1230       1240       1250       1260 
YSGFINRPLP NNQHFQCFVM AELKDQYPVT ANEKQRTFSA SPYSDPIIVQ GENQMQRSVD 

      1270       1280       1290       1300       1310       1320 
QPEMLWVMGP VLAVVLIIII VIAILLFKRK RASPLPKDDH SGGVKDCLLA SSSDPVEMRR 

      1330       1340       1350       1360       1370       1380 
LNYQTPGMRE HPPISVSELA DHIERLKAND ALRFSQEYES IDPGQQFTWE NSNLEVNKPK 

      1390       1400       1410       1420       1430       1440 
NRYANVIAYD HSRVVLTPVD GVPGSDYINS NYIDGYRKQN AYIATQGPLP ETLSDFWRMI 

      1450       1460       1470       1480       1490       1500 
WEQRASTIVM MTRLEEKSRV KCDQYWPIRG TETYGMIQVT MLDAVELATY SVRTFALYKN 

      1510       1520       1530       1540       1550       1560 
GSSEKREVRQ FQFMAWPDHG VPEYPTPILA FLRRVKACNP PDAGPMVVHC SAGVGRTGCF 

      1570       1580       1590       1600       1610       1620 
IVIDAMLERM KHEKTVDIYG HVTCMRSQRN YMVQTEDQYI FIHEALLEAA TCGNTEVPAR 

      1630       1640       1650       1660       1670       1680 
NLYAHIQKLT QPSAGETVTA MELEFKRLAN SKAHTSRFIS ANLPCNKFKN RLVNIMPFES 

      1690       1700       1710       1720       1730       1740 
TRVCLQPIRG VEGSDYINAS CIDGYRQQKA YIATQGPLAE TTEDFWRMLW EHNSTIVVML 

      1750       1760       1770       1780       1790       1800 
TKLREMGREK CHQYWPAERS ARYQYFVVDP MAEYNMPQYI LREFKVTDAR DGQSRTIRQF 

      1810       1820       1830       1840       1850       1860 
QFTDWPEQGV PKTGEGFIDF IGQVHKTKEQ FGQDGPITVH CSAGVGRTGV FITLSIVLER 

      1870       1880       1890       1900 
MRYEGVVDLF QTVKTLRTQR PAMVQTEDQY QLCYRAALEY LGSFDHYAT 

« Hide

References

[1]"The zebrafish reference genome sequence and its relationship to the human genome."
Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J. expand/collapse author list , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Tuebingen.
[2]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX663493, BX248089 Genomic DNA. Translation: CAN88403.1.
BX248089, BX663493 Genomic DNA. Translation: CAQ13596.1.
BC134804 mRNA. Translation: AAI34805.1.
RefSeqNP_001077045.1. NM_001083576.1.
UniGeneDr.12854.

3D structure databases

ProteinModelPortalA4IFW2.
SMRA4IFW2. Positions 320-416, 597-716, 821-913, 918-1008, 1336-1904.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7955.ENSDARP00000077749.

Proteomic databases

PRIDEA4IFW2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSDART00000083314; ENSDARP00000077749; ENSDARG00000005754.
GeneID799867.
KEGGdre:799867.

Organism-specific databases

CTD799867.
ZFINZDB-GENE-060503-530. ptprfb.

Phylogenomic databases

eggNOGCOG5599.
GeneTreeENSGT00590000082937.
HOGENOMHOG000010250.
InParanoidA4IFW2.
KOK05695.
OMAVFTPTIE.
OrthoDBEOG7M98FB.
PhylomeDBA4IFW2.
TreeFamTF312900.

Gene expression databases

BgeeA4IFW2.

Family and domain databases

Gene3D2.60.40.10. 11 hits.
InterProIPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamPF00041. fn3. 7 hits.
PF07679. I-set. 3 hits.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSPR00700. PRTYPHPHTASE.
SMARTSM00060. FN3. 8 hits.
SM00409. IG. 1 hit.
SM00408. IGc2. 2 hits.
SM00194. PTPc. 2 hits.
[Graphical view]
SUPFAMSSF49265. SSF49265. 5 hits.
PROSITEPS50853. FN3. 8 hits.
PS50835. IG_LIKE. 3 hits.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio20934001.
PROA4IFW2.

Entry information

Entry namePTPRF_DANRE
AccessionPrimary (citable) accession number: A4IFW2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 1, 2007
Last modified: April 16, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families