ID   TIM23_BOVIN             Reviewed;         209 AA.
AC   A4IFL0;
DT   25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   27-MAR-2024, entry version 90.
DE   RecName: Full=Mitochondrial import inner membrane translocase subunit Tim23;
GN   Name=TIMM23; Synonyms=TIM23;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Brain cortex;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential component of the TIM23 complex, a complex that
CC       mediates the translocation of transit peptide-containing proteins
CC       across the mitochondrial inner membrane.
CC       {ECO:0000250|UniProtKB:O14925}.
CC   -!- SUBUNIT: Component of the TIM23 complex at least composed of TIMM23,
CC       TIMM17 (TIMM17A or TIMM17B) and TIMM50; within this complex, directly
CC       interacts with TIMM50. The complex interacts with the TIMM44 component
CC       of the PAM complex and with DNAJC15. {ECO:0000250|UniProtKB:O14925}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:O14925}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the Tim17/Tim22/Tim23 family. {ECO:0000305}.
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DR   EMBL; BC134628; AAI34629.1; -; mRNA.
DR   RefSeq; NP_001077127.1; NM_001083658.1.
DR   AlphaFoldDB; A4IFL0; -.
DR   SMR; A4IFL0; -.
DR   STRING; 9913.ENSBTAP00000015525; -.
DR   PaxDb; 9913-ENSBTAP00000015525; -.
DR   Ensembl; ENSBTAT00000015525.5; ENSBTAP00000015525.4; ENSBTAG00000011694.5.
DR   GeneID; 509841; -.
DR   KEGG; bta:509841; -.
DR   CTD; 100287932; -.
DR   VEuPathDB; HostDB:ENSBTAG00000011694; -.
DR   eggNOG; KOG3324; Eukaryota.
DR   GeneTree; ENSGT00390000001094; -.
DR   HOGENOM; CLU_063935_2_0_1; -.
DR   InParanoid; A4IFL0; -.
DR   OMA; DNDNIWS; -.
DR   OrthoDB; 5355126at2759; -.
DR   TreeFam; TF106196; -.
DR   Reactome; R-BTA-1268020; Mitochondrial protein import.
DR   Proteomes; UP000009136; Chromosome 28.
DR   Bgee; ENSBTAG00000011694; Expressed in oocyte and 107 other cell types or tissues.
DR   GO; GO:0005744; C:TIM23 mitochondrial import inner membrane translocase complex; IBA:GO_Central.
DR   GO; GO:0008320; F:protein transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0030150; P:protein import into mitochondrial matrix; IBA:GO_Central.
DR   InterPro; IPR005681; Tim23.
DR   InterPro; IPR045238; Tim23-like.
DR   NCBIfam; TIGR00983; 3a0801s02tim23; 1.
DR   PANTHER; PTHR15371:SF0; MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM23-RELATED; 1.
DR   PANTHER; PTHR15371; TIM23; 1.
DR   Pfam; PF02466; Tim17; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Protein transport;
KW   Reference proteome; Translocation; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..209
FT                   /note="Mitochondrial import inner membrane translocase
FT                   subunit Tim23"
FT                   /id="PRO_0000354674"
FT   TRANSMEM        73..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        125..145
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        172..194
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   209 AA;  21827 MW;  C4F97A3D2FF44838 CRC64;
     MEGGGGSGNK TTGGLAGFFG AGGAGYSHAD LAGVPLTGMN PLSPYLNVDP RYLVQDTDEF
     ILPTGANKTR GRFELAFFTI GGCCMTGAAF GAMNGLRLGL KETQNMAWSK PRNVQILNMV
     TRQGALWANT LGSLALLYSA FGVIIEKTRG AEDDLNTVAA GTMTGMLYKC TGGLRGAARG
     GLAGLTLTGL YALYNNWEHM KGSVLQQSL
//