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A4IFL0

- TIM23_BOVIN

UniProt

A4IFL0 - TIM23_BOVIN

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Protein

Mitochondrial import inner membrane translocase subunit Tim23

Gene

TIMM23

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.By similarity

GO - Molecular functioni

  1. P-P-bond-hydrolysis-driven protein transmembrane transporter activity Source: InterPro

GO - Biological processi

  1. intracellular protein transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiREACT_215731. Mitochondrial protein import.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import inner membrane translocase subunit Tim23
Gene namesi
Name:TIMM23
Synonyms:TIM23
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 28

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane presequence translocase complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 209209Mitochondrial import inner membrane translocase subunit Tim23PRO_0000354674Add
BLAST

Proteomic databases

PRIDEiA4IFL0.

Interactioni

Subunit structurei

Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50; within this complex, directly interacts with TIMM50. The complex interacts with the TIMM44 component of the PAM complex and with DNAJC15.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000015525.

Structurei

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei73 – 9321HelicalSequence AnalysisAdd
BLAST
Transmembranei125 – 14521HelicalSequence AnalysisAdd
BLAST
Transmembranei172 – 19423HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the Tim17/Tim22/Tim23 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5596.
GeneTreeiENSGT00390000001094.
HOGENOMiHOG000166435.
HOVERGENiHBG057526.
InParanoidiA4IFL0.
KOiK17794.
OMAiLKETRDM.
OrthoDBiEOG718KFR.
TreeFamiTF106196.

Family and domain databases

InterProiIPR003397. Tim17/Tim22/Tim23/PMP24.
IPR005681. Tim23.
[Graphical view]
PfamiPF02466. Tim17. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00983. 3a0801s02tim23. 1 hit.

Sequencei

Sequence statusi: Complete.

A4IFL0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEGGGGSGNK TTGGLAGFFG AGGAGYSHAD LAGVPLTGMN PLSPYLNVDP
60 70 80 90 100
RYLVQDTDEF ILPTGANKTR GRFELAFFTI GGCCMTGAAF GAMNGLRLGL
110 120 130 140 150
KETQNMAWSK PRNVQILNMV TRQGALWANT LGSLALLYSA FGVIIEKTRG
160 170 180 190 200
AEDDLNTVAA GTMTGMLYKC TGGLRGAARG GLAGLTLTGL YALYNNWEHM

KGSVLQQSL
Length:209
Mass (Da):21,827
Last modified:May 1, 2007 - v1
Checksum:iC4F97A3D2FF44838
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC134628 mRNA. Translation: AAI34629.1.
RefSeqiNP_001077127.1. NM_001083658.1.
UniGeneiBt.20686.

Genome annotation databases

EnsembliENSBTAT00000015525; ENSBTAP00000015525; ENSBTAG00000011694.
GeneIDi509841.
KEGGibta:509841.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC134628 mRNA. Translation: AAI34629.1 .
RefSeqi NP_001077127.1. NM_001083658.1.
UniGenei Bt.20686.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000015525.

Proteomic databases

PRIDEi A4IFL0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000015525 ; ENSBTAP00000015525 ; ENSBTAG00000011694 .
GeneIDi 509841.
KEGGi bta:509841.

Organism-specific databases

CTDi 100287932.

Phylogenomic databases

eggNOGi COG5596.
GeneTreei ENSGT00390000001094.
HOGENOMi HOG000166435.
HOVERGENi HBG057526.
InParanoidi A4IFL0.
KOi K17794.
OMAi LKETRDM.
OrthoDBi EOG718KFR.
TreeFami TF106196.

Enzyme and pathway databases

Reactomei REACT_215731. Mitochondrial protein import.

Miscellaneous databases

NextBioi 20869159.

Family and domain databases

InterProi IPR003397. Tim17/Tim22/Tim23/PMP24.
IPR005681. Tim23.
[Graphical view ]
Pfami PF02466. Tim17. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00983. 3a0801s02tim23. 1 hit.
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Brain cortex.

Entry informationi

Entry nameiTIM23_BOVIN
AccessioniPrimary (citable) accession number: A4IFL0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: May 1, 2007
Last modified: October 1, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3