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A4IFL0

- TIM23_BOVIN

UniProt

A4IFL0 - TIM23_BOVIN

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Protein

Mitochondrial import inner membrane translocase subunit Tim23

Gene
TIMM23, TIM23
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane By similarity.

GO - Molecular functioni

  1. P-P-bond-hydrolysis-driven protein transmembrane transporter activity Source: InterPro

GO - Biological processi

  1. intracellular protein transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiREACT_215731. Mitochondrial protein import.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import inner membrane translocase subunit Tim23
Gene namesi
Name:TIMM23
Synonyms:TIM23
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 28

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei73 – 9321Helical; Reviewed predictionAdd
BLAST
Transmembranei125 – 14521Helical; Reviewed predictionAdd
BLAST
Transmembranei172 – 19423Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane presequence translocase complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 209209Mitochondrial import inner membrane translocase subunit Tim23PRO_0000354674Add
BLAST

Proteomic databases

PRIDEiA4IFL0.

Interactioni

Subunit structurei

Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50; within this complex, directly interacts with TIMM50 By similarity. The complex interacts with the TIMM44 component of the PAM complex and with DNAJC15 By similarity.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000015525.

Family & Domainsi

Sequence similaritiesi

Belongs to the Tim17/Tim22/Tim23 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5596.
GeneTreeiENSGT00390000001094.
HOGENOMiHOG000166435.
HOVERGENiHBG057526.
InParanoidiA4IFL0.
KOiK17794.
OMAiLKETRDM.
OrthoDBiEOG718KFR.
TreeFamiTF106196.

Family and domain databases

InterProiIPR003397. Tim17/Tim22/Tim23/PMP24.
IPR005681. Tim23.
[Graphical view]
PfamiPF02466. Tim17. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00983. 3a0801s02tim23. 1 hit.

Sequencei

Sequence statusi: Complete.

A4IFL0-1 [UniParc]FASTAAdd to Basket

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MEGGGGSGNK TTGGLAGFFG AGGAGYSHAD LAGVPLTGMN PLSPYLNVDP    50
RYLVQDTDEF ILPTGANKTR GRFELAFFTI GGCCMTGAAF GAMNGLRLGL 100
KETQNMAWSK PRNVQILNMV TRQGALWANT LGSLALLYSA FGVIIEKTRG 150
AEDDLNTVAA GTMTGMLYKC TGGLRGAARG GLAGLTLTGL YALYNNWEHM 200
KGSVLQQSL 209
Length:209
Mass (Da):21,827
Last modified:May 1, 2007 - v1
Checksum:iC4F97A3D2FF44838
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC134628 mRNA. Translation: AAI34629.1.
RefSeqiNP_001077127.1. NM_001083658.1.
UniGeneiBt.20686.

Genome annotation databases

EnsembliENSBTAT00000015525; ENSBTAP00000015525; ENSBTAG00000011694.
GeneIDi509841.
KEGGibta:509841.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC134628 mRNA. Translation: AAI34629.1 .
RefSeqi NP_001077127.1. NM_001083658.1.
UniGenei Bt.20686.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000015525.

Proteomic databases

PRIDEi A4IFL0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000015525 ; ENSBTAP00000015525 ; ENSBTAG00000011694 .
GeneIDi 509841.
KEGGi bta:509841.

Organism-specific databases

CTDi 100287932.

Phylogenomic databases

eggNOGi COG5596.
GeneTreei ENSGT00390000001094.
HOGENOMi HOG000166435.
HOVERGENi HBG057526.
InParanoidi A4IFL0.
KOi K17794.
OMAi LKETRDM.
OrthoDBi EOG718KFR.
TreeFami TF106196.

Enzyme and pathway databases

Reactomei REACT_215731. Mitochondrial protein import.

Miscellaneous databases

NextBioi 20869159.

Family and domain databases

InterProi IPR003397. Tim17/Tim22/Tim23/PMP24.
IPR005681. Tim23.
[Graphical view ]
Pfami PF02466. Tim17. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00983. 3a0801s02tim23. 1 hit.
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Brain cortex.

Entry informationi

Entry nameiTIM23_BOVIN
AccessioniPrimary (citable) accession number: A4IFL0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: May 1, 2007
Last modified: September 3, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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