Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A4IFL0 (TIM23_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitochondrial import inner membrane translocase subunit Tim23
Gene names
Name:TIMM23
Synonyms:TIM23
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length209 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane By similarity.

Subunit structure

Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50; within this complex, directly interacts with TIMM50 By similarity. The complex interacts with the TIMM44 component of the PAM complex and with DNAJC15 By similarity.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the Tim17/Tim22/Tim23 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 209209Mitochondrial import inner membrane translocase subunit Tim23
PRO_0000354674

Regions

Transmembrane73 – 9321Helical; Potential
Transmembrane125 – 14521Helical; Potential
Transmembrane172 – 19423Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A4IFL0 [UniParc].

Last modified May 1, 2007. Version 1.
Checksum: C4F97A3D2FF44838

FASTA20921,827
        10         20         30         40         50         60 
MEGGGGSGNK TTGGLAGFFG AGGAGYSHAD LAGVPLTGMN PLSPYLNVDP RYLVQDTDEF 

        70         80         90        100        110        120 
ILPTGANKTR GRFELAFFTI GGCCMTGAAF GAMNGLRLGL KETQNMAWSK PRNVQILNMV 

       130        140        150        160        170        180 
TRQGALWANT LGSLALLYSA FGVIIEKTRG AEDDLNTVAA GTMTGMLYKC TGGLRGAARG 

       190        200 
GLAGLTLTGL YALYNNWEHM KGSVLQQSL 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Brain cortex.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC134628 mRNA. Translation: AAI34629.1.
RefSeqNP_001077127.1. NM_001083658.1.
UniGeneBt.20686.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000015525.

Proteomic databases

PRIDEA4IFL0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000015525; ENSBTAP00000015525; ENSBTAG00000011694.
GeneID509841.
KEGGbta:509841.

Organism-specific databases

CTD100287932.

Phylogenomic databases

eggNOGCOG5596.
GeneTreeENSGT00390000001094.
HOGENOMHOG000166435.
HOVERGENHBG057526.
InParanoidA4IFL0.
KOK17794.
OMALKETRDM.
OrthoDBEOG718KFR.
TreeFamTF106196.

Family and domain databases

InterProIPR003397. Tim17/Tim22/Tim23/PMP24.
IPR005681. Tim23.
[Graphical view]
PfamPF02466. Tim17. 1 hit.
[Graphical view]
TIGRFAMsTIGR00983. 3a0801s02tim23. 1 hit.
ProtoNetSearch...

Other

NextBio20869159.

Entry information

Entry nameTIM23_BOVIN
AccessionPrimary (citable) accession number: A4IFL0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: May 1, 2007
Last modified: April 16, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families