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A4IFL0

- TIM23_BOVIN

UniProt

A4IFL0 - TIM23_BOVIN

Protein

Mitochondrial import inner membrane translocase subunit Tim23

Gene

TIMM23

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (01 May 2007)
      Previous versions | rss
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    Functioni

    Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.By similarity

    GO - Molecular functioni

    1. P-P-bond-hydrolysis-driven protein transmembrane transporter activity Source: InterPro

    GO - Biological processi

    1. intracellular protein transport Source: InterPro

    Keywords - Biological processi

    Protein transport, Translocation, Transport

    Enzyme and pathway databases

    ReactomeiREACT_215731. Mitochondrial protein import.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial import inner membrane translocase subunit Tim23
    Gene namesi
    Name:TIMM23
    Synonyms:TIM23
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 28

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane presequence translocase complex Source: InterPro

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 209209Mitochondrial import inner membrane translocase subunit Tim23PRO_0000354674Add
    BLAST

    Proteomic databases

    PRIDEiA4IFL0.

    Interactioni

    Subunit structurei

    Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50; within this complex, directly interacts with TIMM50. The complex interacts with the TIMM44 component of the PAM complex and with DNAJC15.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000015525.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei73 – 9321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei125 – 14521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei172 – 19423HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Tim17/Tim22/Tim23 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5596.
    GeneTreeiENSGT00390000001094.
    HOGENOMiHOG000166435.
    HOVERGENiHBG057526.
    InParanoidiA4IFL0.
    KOiK17794.
    OMAiLKETRDM.
    OrthoDBiEOG718KFR.
    TreeFamiTF106196.

    Family and domain databases

    InterProiIPR003397. Tim17/Tim22/Tim23/PMP24.
    IPR005681. Tim23.
    [Graphical view]
    PfamiPF02466. Tim17. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00983. 3a0801s02tim23. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A4IFL0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEGGGGSGNK TTGGLAGFFG AGGAGYSHAD LAGVPLTGMN PLSPYLNVDP    50
    RYLVQDTDEF ILPTGANKTR GRFELAFFTI GGCCMTGAAF GAMNGLRLGL 100
    KETQNMAWSK PRNVQILNMV TRQGALWANT LGSLALLYSA FGVIIEKTRG 150
    AEDDLNTVAA GTMTGMLYKC TGGLRGAARG GLAGLTLTGL YALYNNWEHM 200
    KGSVLQQSL 209
    Length:209
    Mass (Da):21,827
    Last modified:May 1, 2007 - v1
    Checksum:iC4F97A3D2FF44838
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC134628 mRNA. Translation: AAI34629.1.
    RefSeqiNP_001077127.1. NM_001083658.1.
    UniGeneiBt.20686.

    Genome annotation databases

    EnsembliENSBTAT00000015525; ENSBTAP00000015525; ENSBTAG00000011694.
    GeneIDi509841.
    KEGGibta:509841.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC134628 mRNA. Translation: AAI34629.1 .
    RefSeqi NP_001077127.1. NM_001083658.1.
    UniGenei Bt.20686.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000015525.

    Proteomic databases

    PRIDEi A4IFL0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000015525 ; ENSBTAP00000015525 ; ENSBTAG00000011694 .
    GeneIDi 509841.
    KEGGi bta:509841.

    Organism-specific databases

    CTDi 100287932.

    Phylogenomic databases

    eggNOGi COG5596.
    GeneTreei ENSGT00390000001094.
    HOGENOMi HOG000166435.
    HOVERGENi HBG057526.
    InParanoidi A4IFL0.
    KOi K17794.
    OMAi LKETRDM.
    OrthoDBi EOG718KFR.
    TreeFami TF106196.

    Enzyme and pathway databases

    Reactomei REACT_215731. Mitochondrial protein import.

    Miscellaneous databases

    NextBioi 20869159.

    Family and domain databases

    InterProi IPR003397. Tim17/Tim22/Tim23/PMP24.
    IPR005681. Tim23.
    [Graphical view ]
    Pfami PF02466. Tim17. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00983. 3a0801s02tim23. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Brain cortex.

    Entry informationi

    Entry nameiTIM23_BOVIN
    AccessioniPrimary (citable) accession number: A4IFL0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 25, 2008
    Last sequence update: May 1, 2007
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3