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A4IFH5

- ALAT1_BOVIN

UniProt

A4IFH5 - ALAT1_BOVIN

Protein

Alanine aminotransferase 1

Gene

GPT

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (01 May 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles By similarity.By similarity

    Catalytic activityi

    L-alanine + 2-oxoglutarate = pyruvate + L-glutamate.

    Cofactori

    Pyridoxal phosphate.By similarity

    Pathwayi

    GO - Molecular functioni

    1. L-alanine:2-oxoglutarate aminotransferase activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. biosynthetic process Source: InterPro
    2. L-alanine catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    ReactomeiREACT_217400. Amino acid synthesis and interconversion (transamination).
    UniPathwayiUPA00528; UER00586.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine aminotransferase 1 (EC:2.6.1.2)
    Short name:
    ALT1
    Alternative name(s):
    Glutamate pyruvate transaminase 1
    Short name:
    GPT 1
    Glutamic--alanine transaminase 1
    Glutamic--pyruvic transaminase 1
    Gene namesi
    Name:GPT
    Synonyms:GPT1
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 14

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed
    Chaini2 – 496495Alanine aminotransferase 1PRO_0000328385Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine
    Modified residuei314 – 3141N6-(pyridoxal phosphate)lysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PRIDEiA4IFH5.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliA4IFH5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0436.
    GeneTreeiENSGT00650000093331.
    HOGENOMiHOG000215020.
    HOVERGENiHBG026148.
    InParanoidiA4IFH5.
    KOiK00814.
    OMAiHAKFTLE.
    OrthoDBiEOG76HQ18.
    TreeFamiTF300839.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProiIPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PfamiPF00155. Aminotran_1_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A4IFH5-1 [UniParc]FASTAAdd to Basket

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    MALRAGEHSQ EAANGLKEKV LTLDSMNPYV RRVEYAVRGP IVQRALELEQ    50
    ELRQGVKKPF TEVIRANIGD AQAMGQIPIT FPRQVLALCV HPDLLNSPDF 100
    PDDAKRRAER ILQACGGHSL GAYSISAGVQ MIREDVARYI ERRDGGIPAD 150
    PNNIFLSTGA SDAIVTVLKL LVTGEGRTRT GVLIPIPQYP LYSAALAEFN 200
    AVQVDYYLDE ERAWALDVAE LRRALRQARD HCRPRALCVI NPGNPTGQVQ 250
    TRECIEDVIR FAYEEKLFLL ADEVYQDNVY AESSQFHSFK KVLTEMGPPY 300
    AAQQELASFH SISKGYMGEC GFRGGYVEVV NMDAAVKQQM QKLRSVRLCP 350
    PTPGQVLLDV AVSPPAPSDP SFPRFQAERR AVLAELAAKA KLTEQVFNEA 400
    PGIRCNPVQG AMYSFPRVQL PPRAVQRAQE LGLAPDMFFC LRLLEETGIC 450
    VVPGSGFGQR EGTYHFRMTI LPPMEKLRPL LEKLSQFHAK FTREYS 496
    Length:496
    Mass (Da):55,275
    Last modified:May 1, 2007 - v1
    Checksum:iEA136706AA816ED0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC134583 mRNA. Translation: AAI34584.1.
    RefSeqiNP_001077209.1. NM_001083740.2.
    UniGeneiBt.9623.

    Genome annotation databases

    EnsembliENSBTAT00000010309; ENSBTAP00000010309; ENSBTAG00000007835.
    GeneIDi539188.
    KEGGibta:539188.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC134583 mRNA. Translation: AAI34584.1 .
    RefSeqi NP_001077209.1. NM_001083740.2.
    UniGenei Bt.9623.

    3D structure databases

    ProteinModelPortali A4IFH5.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi A4IFH5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000010309 ; ENSBTAP00000010309 ; ENSBTAG00000007835 .
    GeneIDi 539188.
    KEGGi bta:539188.

    Organism-specific databases

    CTDi 2875.

    Phylogenomic databases

    eggNOGi COG0436.
    GeneTreei ENSGT00650000093331.
    HOGENOMi HOG000215020.
    HOVERGENi HBG026148.
    InParanoidi A4IFH5.
    KOi K00814.
    OMAi HAKFTLE.
    OrthoDBi EOG76HQ18.
    TreeFami TF300839.

    Enzyme and pathway databases

    UniPathwayi UPA00528 ; UER00586 .
    Reactomei REACT_217400. Amino acid synthesis and interconversion (transamination).

    Miscellaneous databases

    NextBioi 20877836.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProi IPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    Pfami PF00155. Aminotran_1_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Hypothalamus.

    Entry informationi

    Entry nameiALAT1_BOVIN
    AccessioniPrimary (citable) accession number: A4IFH5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: May 1, 2007
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3