Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

DNA ligase

Gene

LIG1

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotation
Biological processDNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-BTA-110362 POLB-Dependent Long Patch Base Excision Repair
R-BTA-174414 Processive synthesis on the C-strand of the telomere
R-BTA-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
R-BTA-5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
R-BTA-5651801 PCNA-Dependent Long Patch Base Excision Repair
R-BTA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-BTA-69183 Processive synthesis on the lagging strand

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
Name:LIG1Imported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi

Organism-specific databases

VGNCiVGNC:30882 LIG1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSBTAG00000014595

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000031866

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini645 – 781DNA_LIGASE_A3InterPro annotationAdd BLAST137

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0967 Eukaryota
COG1793 LUCA
GeneTreeiENSGT00860000133792
HOGENOMiHOG000036006
HOVERGENiHBG005514
KOiK10747
OMAiWIKYKRD
OrthoDBiEOG091G06OS
TreeFamiTF300342

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
InterProiView protein in InterPro
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS00333 DNA_LIGASE_A2, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

A4IFC8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRSIMSFFQ PKKEGKAKKP EKETAKSIRE TESPPKVALK ERNRVVSEGD
60 70 80 90 100
SPVKRPGRKA TRVLGSEGEE EEEEAPTTPR SQKPASDSPQ ASPPSPVTLP
110 120 130 140 150
ESSPSHSKPS PAVASPSGIP KRRTARKQLP KRTFQDVLKE QGEDKDPETK
160 170 180 190 200
KKKEEEAETP IESLPEPEGD DKEEVEGGDQ PTTPPEPRKT STESLTESVS
210 220 230 240 250
EPGVTVKQEP QEDGQAQPPP KTPKTLSSFF SPRKPAVKKE AKEEGPGALR
260 270 280 290 300
KDEIKGHVDP ASYNPAKNNY HPIEDACWKA GQRVPYLAVA RAFEKIEEVS
310 320 330 340 350
ARLRMVETLS NLLRSVVALS PADLLPVLYL SLNRLGPPQQ GLELGIGEGI
360 370 380 390 400
LLKAVAQATG RQLESVRAEV AEKGDVGLVA ESSRSTQRLV LPPPALTAAG
410 420 430 440 450
VFAKFRDIAQ LAGSASTTKK IDVIKGLFVA CRHSEARFIA RALSGRLRLG
460 470 480 490 500
LAEQSVLAAL AQAVSLTPPS QECPPAVVDA GKGKTAEARK TWLEEQGMIL
510 520 530 540 550
KQTFCEVPDL ERIVPVLLEH GLERLPEHCR LSPGVPLKPM LAHPTRGVSE
560 570 580 590 600
VLKRFEEAAF TCEYKYDGQR AQIHVLEGGE VKIFSRNQED NTGRYPDIIS
610 620 630 640 650
RIPKIKLPSV TSFILDTEAV AWDREKKQIQ PFQVLTTRKR KEVDAAEIQV
660 670 680 690 700
QVCLYAFDLI YLNGKSLVRE PLSRRRQLLR ENFVETEGEF VFATSLDTKD
710 720 730 740 750
TEQIAEFLEQ SVKDSCEGLM VKTLDVDATY EIAKRSHNWL KLKKDYLEGV
760 770 780 790 800
GDTLDLVVIG AYLGKGKRAG RYGGFLLASY DEESEEFQAI CKLGTGFSDE
810 820 830 840 850
ELEEHHQRLQ ALVLPTPRSY VRADGAVAPD HWLDPSDVWE VKCADLSLSP
860 870 880 890 900
IYPAARGLVD SEKGISLRFP RFIRVREDKK PEQATTSAQV AGLYKKQSQI
910
QNQQGAEPDS EQEEFY
Length:916
Mass (Da):101,316
Last modified:May 1, 2007 - v1
Checksum:i703226C6B9D7594B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02047435 Genomic DNA No translation available.
BC134518 mRNA Translation: AAI34519.1
RefSeqiNP_001096018.1, NM_001102548.1
UniGeneiBt.12876

Genome annotation databases

EnsembliENSBTAT00000031920; ENSBTAP00000031866; ENSBTAG00000014595
GeneIDi100124507
KEGGibta:100124507

Entry informationi

Entry nameiA4IFC8_BOVIN
AccessioniPrimary (citable) accession number: A4IFC8
Secondary accession number(s): F1MSC6
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2007
Last sequence update: May 1, 2007
Last modified: March 28, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health