Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A4IFC8

- A4IFC8_BOVIN

UniProt

A4IFC8 - A4IFC8_BOVIN

Protein

DNA ligase

Gene

LIG1

Organism
Bos taurus (Bovine)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (01 May 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: RefGenome

    GO - Biological processi

    1. DNA ligation Source: RefGenome
    2. DNA ligation involved in DNA repair Source: InterPro
    3. DNA recombination Source: UniProtKB-KW
    4. double-strand break repair via nonhomologous end joining Source: Ensembl
    5. lagging strand elongation Source: RefGenome
    6. response to hydrogen peroxide Source: Ensembl

    Keywords - Molecular functioni

    LigaseUniRule annotation

    Keywords - Biological processi

    DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_205725. Processive synthesis on the C-strand of the telomere.
    REACT_211321. Resolution of D-loop structures through Holliday junction intermediates.
    REACT_214477. Gap-filling DNA repair synthesis and ligation in GG-NER.
    REACT_217593. Gap-filling DNA repair synthesis and ligation in TC-NER.
    REACT_218453. Resolution of AP sites via the multiple-nucleotide patch replacement pathway.
    REACT_221571. Processive synthesis on the lagging strand.
    REACT_227100. Removal of DNA patch containing abasic residue.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Gene namesi
    Name:LIG1Imported
    OrganismiBos taurus (Bovine)Imported
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 18

    Subcellular locationi

    GO - Cellular componenti

    1. chromosome Source: RefGenome
    2. mitochondrion Source: RefGenome
    3. nucleus Source: RefGenome

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000019427.

    Structurei

    3D structure databases

    ProteinModelPortaliA4IFC8.
    SMRiA4IFC8. Positions 259-898.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1793.
    GeneTreeiENSGT00750000117745.
    HOGENOMiHOG000036006.
    HOVERGENiHBG005514.
    KOiK10747.
    OMAiLDPSGYN.
    OrthoDBiEOG7RFTGN.
    TreeFamiTF300342.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    InterProiIPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A4IFC8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQRSIMSFFQ PKKEGKAKKP EKETAKSIRE TESPPKVALK ERNRVVSEGD    50
    SPVKRPGRKA TRVLGSEGEE EEEEAPTTPR SQKPASDSPQ ASPPSPVTLP 100
    ESSPSHSKPS PAVASPSGIP KRRTARKQLP KRTFQDVLKE QGEDKDPETK 150
    KKKEEEAETP IESLPEPEGD DKEEVEGGDQ PTTPPEPRKT STESLTESVS 200
    EPGVTVKQEP QEDGQAQPPP KTPKTLSSFF SPRKPAVKKE AKEEGPGALR 250
    KDEIKGHVDP ASYNPAKNNY HPIEDACWKA GQRVPYLAVA RAFEKIEEVS 300
    ARLRMVETLS NLLRSVVALS PADLLPVLYL SLNRLGPPQQ GLELGIGEGI 350
    LLKAVAQATG RQLESVRAEV AEKGDVGLVA ESSRSTQRLV LPPPALTAAG 400
    VFAKFRDIAQ LAGSASTTKK IDVIKGLFVA CRHSEARFIA RALSGRLRLG 450
    LAEQSVLAAL AQAVSLTPPS QECPPAVVDA GKGKTAEARK TWLEEQGMIL 500
    KQTFCEVPDL ERIVPVLLEH GLERLPEHCR LSPGVPLKPM LAHPTRGVSE 550
    VLKRFEEAAF TCEYKYDGQR AQIHVLEGGE VKIFSRNQED NTGRYPDIIS 600
    RIPKIKLPSV TSFILDTEAV AWDREKKQIQ PFQVLTTRKR KEVDAAEIQV 650
    QVCLYAFDLI YLNGKSLVRE PLSRRRQLLR ENFVETEGEF VFATSLDTKD 700
    TEQIAEFLEQ SVKDSCEGLM VKTLDVDATY EIAKRSHNWL KLKKDYLEGV 750
    GDTLDLVVIG AYLGKGKRAG RYGGFLLASY DEESEEFQAI CKLGTGFSDE 800
    ELEEHHQRLQ ALVLPTPRSY VRADGAVAPD HWLDPSDVWE VKCADLSLSP 850
    IYPAARGLVD SEKGISLRFP RFIRVREDKK PEQATTSAQV AGLYKKQSQI 900
    QNQQGAEPDS EQEEFY 916
    Length:916
    Mass (Da):101,316
    Last modified:May 1, 2007 - v1
    Checksum:i703226C6B9D7594B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DAAA02047435 Genomic DNA. No translation available.
    BC134518 mRNA. Translation: AAI34519.1.
    RefSeqiNP_001096018.1. NM_001102548.1.
    UniGeneiBt.12876.

    Genome annotation databases

    EnsembliENSBTAT00000031920; ENSBTAP00000031866; ENSBTAG00000014595.
    GeneIDi100124507.
    KEGGibta:100124507.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DAAA02047435 Genomic DNA. No translation available.
    BC134518 mRNA. Translation: AAI34519.1 .
    RefSeqi NP_001096018.1. NM_001102548.1.
    UniGenei Bt.12876.

    3D structure databases

    ProteinModelPortali A4IFC8.
    SMRi A4IFC8. Positions 259-898.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000019427.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000031920 ; ENSBTAP00000031866 ; ENSBTAG00000014595 .
    GeneIDi 100124507.
    KEGGi bta:100124507.

    Organism-specific databases

    CTDi 3978.

    Phylogenomic databases

    eggNOGi COG1793.
    GeneTreei ENSGT00750000117745.
    HOGENOMi HOG000036006.
    HOVERGENi HBG005514.
    KOi K10747.
    OMAi LDPSGYN.
    OrthoDBi EOG7RFTGN.
    TreeFami TF300342.

    Enzyme and pathway databases

    Reactomei REACT_205725. Processive synthesis on the C-strand of the telomere.
    REACT_211321. Resolution of D-loop structures through Holliday junction intermediates.
    REACT_214477. Gap-filling DNA repair synthesis and ligation in GG-NER.
    REACT_217593. Gap-filling DNA repair synthesis and ligation in TC-NER.
    REACT_218453. Resolution of AP sites via the multiple-nucleotide patch replacement pathway.
    REACT_221571. Processive synthesis on the lagging strand.
    REACT_227100. Removal of DNA patch containing abasic residue.

    Miscellaneous databases

    NextBioi 20788728.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    InterProi IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: L1 HerefordImported.
      Tissue: Ascending colonImported.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HerefordImported.
    3. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: HerefordImported.

    Entry informationi

    Entry nameiA4IFC8_BOVIN
    AccessioniPrimary (citable) accession number: A4IFC8
    Secondary accession number(s): F1MSC6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 1, 2007
    Last sequence update: May 1, 2007
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3