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Protein

DNA ligase

Gene

LIG1

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

DNA damage, DNA recombination, DNA repair, DNA replication

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_297661. Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha).
REACT_298938. Resolution of D-loop structures through Holliday junction intermediates.
REACT_306011. Processive synthesis on the lagging strand.
REACT_319323. Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta).
REACT_319869. Gap-filling DNA repair synthesis and ligation in TC-NER.
REACT_322551. POLB-Dependent Long Patch Base Excision Repair.
REACT_324642. Gap-filling DNA repair synthesis and ligation in GG-NER.
REACT_328362. Processive synthesis on the C-strand of the telomere.
REACT_362106. PCNA-Dependent Long Patch Base Excision Repair.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligase (EC:6.5.1.1)
Gene namesi
Name:LIG1Imported
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Chromosome 18

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000019427.

Structurei

3D structure databases

ProteinModelPortaliA4IFC8.
SMRiA4IFC8. Positions 259-898.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1793.
GeneTreeiENSGT00780000121970.
HOGENOMiHOG000036006.
HOVERGENiHBG005514.
InParanoidiA4IFC8.
KOiK10747.
OMAiPQVVIEV.
OrthoDBiEOG7RFTGN.
TreeFamiTF300342.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4IFC8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRSIMSFFQ PKKEGKAKKP EKETAKSIRE TESPPKVALK ERNRVVSEGD
60 70 80 90 100
SPVKRPGRKA TRVLGSEGEE EEEEAPTTPR SQKPASDSPQ ASPPSPVTLP
110 120 130 140 150
ESSPSHSKPS PAVASPSGIP KRRTARKQLP KRTFQDVLKE QGEDKDPETK
160 170 180 190 200
KKKEEEAETP IESLPEPEGD DKEEVEGGDQ PTTPPEPRKT STESLTESVS
210 220 230 240 250
EPGVTVKQEP QEDGQAQPPP KTPKTLSSFF SPRKPAVKKE AKEEGPGALR
260 270 280 290 300
KDEIKGHVDP ASYNPAKNNY HPIEDACWKA GQRVPYLAVA RAFEKIEEVS
310 320 330 340 350
ARLRMVETLS NLLRSVVALS PADLLPVLYL SLNRLGPPQQ GLELGIGEGI
360 370 380 390 400
LLKAVAQATG RQLESVRAEV AEKGDVGLVA ESSRSTQRLV LPPPALTAAG
410 420 430 440 450
VFAKFRDIAQ LAGSASTTKK IDVIKGLFVA CRHSEARFIA RALSGRLRLG
460 470 480 490 500
LAEQSVLAAL AQAVSLTPPS QECPPAVVDA GKGKTAEARK TWLEEQGMIL
510 520 530 540 550
KQTFCEVPDL ERIVPVLLEH GLERLPEHCR LSPGVPLKPM LAHPTRGVSE
560 570 580 590 600
VLKRFEEAAF TCEYKYDGQR AQIHVLEGGE VKIFSRNQED NTGRYPDIIS
610 620 630 640 650
RIPKIKLPSV TSFILDTEAV AWDREKKQIQ PFQVLTTRKR KEVDAAEIQV
660 670 680 690 700
QVCLYAFDLI YLNGKSLVRE PLSRRRQLLR ENFVETEGEF VFATSLDTKD
710 720 730 740 750
TEQIAEFLEQ SVKDSCEGLM VKTLDVDATY EIAKRSHNWL KLKKDYLEGV
760 770 780 790 800
GDTLDLVVIG AYLGKGKRAG RYGGFLLASY DEESEEFQAI CKLGTGFSDE
810 820 830 840 850
ELEEHHQRLQ ALVLPTPRSY VRADGAVAPD HWLDPSDVWE VKCADLSLSP
860 870 880 890 900
IYPAARGLVD SEKGISLRFP RFIRVREDKK PEQATTSAQV AGLYKKQSQI
910
QNQQGAEPDS EQEEFY
Length:916
Mass (Da):101,316
Last modified:May 1, 2007 - v1
Checksum:i703226C6B9D7594B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02047435 Genomic DNA. No translation available.
BC134518 mRNA. Translation: AAI34519.1.
RefSeqiNP_001096018.1. NM_001102548.1.
UniGeneiBt.12876.

Genome annotation databases

EnsembliENSBTAT00000031920; ENSBTAP00000031866; ENSBTAG00000014595.
GeneIDi100124507.
KEGGibta:100124507.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02047435 Genomic DNA. No translation available.
BC134518 mRNA. Translation: AAI34519.1.
RefSeqiNP_001096018.1. NM_001102548.1.
UniGeneiBt.12876.

3D structure databases

ProteinModelPortaliA4IFC8.
SMRiA4IFC8. Positions 259-898.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000019427.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000031920; ENSBTAP00000031866; ENSBTAG00000014595.
GeneIDi100124507.
KEGGibta:100124507.

Organism-specific databases

CTDi3978.

Phylogenomic databases

eggNOGiCOG1793.
GeneTreeiENSGT00780000121970.
HOGENOMiHOG000036006.
HOVERGENiHBG005514.
InParanoidiA4IFC8.
KOiK10747.
OMAiPQVVIEV.
OrthoDBiEOG7RFTGN.
TreeFamiTF300342.

Enzyme and pathway databases

ReactomeiREACT_297661. Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha).
REACT_298938. Resolution of D-loop structures through Holliday junction intermediates.
REACT_306011. Processive synthesis on the lagging strand.
REACT_319323. Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta).
REACT_319869. Gap-filling DNA repair synthesis and ligation in TC-NER.
REACT_322551. POLB-Dependent Long Patch Base Excision Repair.
REACT_324642. Gap-filling DNA repair synthesis and ligation in GG-NER.
REACT_328362. Processive synthesis on the C-strand of the telomere.
REACT_362106. PCNA-Dependent Long Patch Base Excision Repair.

Miscellaneous databases

NextBioi20788728.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: L1 HerefordImported.
    Tissue: Ascending colonImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HerefordImported.
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: HerefordImported.

Entry informationi

Entry nameiA4IFC8_BOVIN
AccessioniPrimary (citable) accession number: A4IFC8
Secondary accession number(s): F1MSC6
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2007
Last sequence update: May 1, 2007
Last modified: May 27, 2015
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.