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Protein

Dihydroxyacetone phosphate acyltransferase

Gene

GNPAT

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Acyl-CoA + glycerone phosphate = CoA + acylglycerone phosphate.

Pathwayi: glycerophospholipid metabolism

This protein is involved in the pathway glycerophospholipid metabolism, which is part of Membrane lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway glycerophospholipid metabolism and in Membrane lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00940.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydroxyacetone phosphate acyltransferase (EC:2.3.1.42)
Short name:
DAP-AT
Short name:
DHAP-AT
Alternative name(s):
Acyl-CoA:dihydroxyacetonephosphateacyltransferase
Glycerone-phosphate O-acyltransferase
Gene namesi
Name:GNPAT
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003258551 – 680Dihydroxyacetone phosphate acyltransferaseAdd BLAST680

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei12PhosphoserineBy similarity1
Modified residuei17PhosphoserineBy similarity1
Modified residuei643N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiA4IF87.

Interactioni

Subunit structurei

May be part of a heterotrimeric complex composed of DAP-AT, ADAP-S and a modified form of DAP-AT.By similarity

Structurei

3D structure databases

ProteinModelPortaliA4IF87.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi162 – 167HXXXXD motif6
Motifi678 – 680Microbody targeting signalSequence analysis3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi4 – 9Poly-Ser6

Domaini

The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.By similarity

Sequence similaritiesi

Belongs to the GPAT/DAPAT family.Curated

Phylogenomic databases

HOGENOMiHOG000112751.
HOVERGENiHBG051749.
InParanoidiA4IF87.
KOiK00649.

Family and domain databases

InterProiIPR028353. DHAPAT.
IPR022284. GPAT/DHAPAT.
IPR002123. Plipid/glycerol_acylTrfase.
[Graphical view]
PANTHERiPTHR12563. PTHR12563. 1 hit.
PfamiPF01553. Acyltransferase. 1 hit.
[Graphical view]
PIRSFiPIRSF500063. DHAPAT. 1 hit.
PIRSF000437. GPAT_DHAPAT. 1 hit.
SMARTiSM00563. PlsC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4IF87-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDHSSSSNSC FSVGSTSPGA VVLLYSKELK KWDEFEDVLE ERRHVSDLKF
60 70 80 90 100
AMKCYTPLVY KGITPCKPSD IKCSVLNSEE IHYVIKQLSK ESLQPVEVLR
110 120 130 140 150
EEACEILDEM SHKLRLGAIR FFAFALSKIF KQIFSKVRVN EEGIQKLQRA
160 170 180 190 200
IQEHPVVLLP SHRSYIDFLM LSFLLYNYDL PVPVIAAGMD FLGMKMVGEL
210 220 230 240 250
LRMSGAFFMR RTFGGNKLYW AVFSEYVKTM LRNGYAPVEF FLEGTRSRSA
260 270 280 290 300
KTLTPKFGLL NIVMEPFFKR EVFDTYLVPI SISYDRILEE TLYAYELLGV
310 320 330 340 350
PKPKESTTGL LKARRILSEK FGNIHVYFGD PVSLRSLAAG RMGRSPYNLV
360 370 380 390 400
PRYIPQKQSE EMHTFVTEVA YKMQLLQIQN LVLSPWPLIV AVLLQNRPSI
410 420 430 440 450
DFDALLEKTL WLKGLTQAFG GFLTWPDNEP AEAVIQSSIL LHSNIVSLVK
460 470 480 490 500
DRVILKMECG DSELVDGLIF QHITLLMCLA YRNQLLNVFV RPSLVAMALQ
510 520 530 540 550
MTPGFRKEDV YSCFRFLCSV FSDEFIFLPG NALKDFEEGC YLLCKSEAIQ
560 570 580 590 600
VMTRDILVTE KGNSVLEFLI GLFKPFVESY QIICKYLLNE EEDYFTEKQY
610 620 630 640 650
FIRVRKFTSQ LLDQGASQCY DVLSSDVQKN ALAAFVRLGV VEKKKVNNDY
660 670 680
IFNVNEPATT KLEEMLGCKT PVGKPATAKL
Length:680
Mass (Da):77,664
Last modified:May 1, 2007 - v1
Checksum:i9D80C804CB92854F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC134455 mRNA. Translation: AAI34456.1.
RefSeqiNP_001096756.1. NM_001103286.1.
UniGeneiBt.41956.

Genome annotation databases

GeneIDi538800.
KEGGibta:538800.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC134455 mRNA. Translation: AAI34456.1.
RefSeqiNP_001096756.1. NM_001103286.1.
UniGeneiBt.41956.

3D structure databases

ProteinModelPortaliA4IF87.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiA4IF87.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi538800.
KEGGibta:538800.

Organism-specific databases

CTDi8443.

Phylogenomic databases

HOGENOMiHOG000112751.
HOVERGENiHBG051749.
InParanoidiA4IF87.
KOiK00649.

Enzyme and pathway databases

UniPathwayiUPA00940.

Family and domain databases

InterProiIPR028353. DHAPAT.
IPR022284. GPAT/DHAPAT.
IPR002123. Plipid/glycerol_acylTrfase.
[Graphical view]
PANTHERiPTHR12563. PTHR12563. 1 hit.
PfamiPF01553. Acyltransferase. 1 hit.
[Graphical view]
PIRSFiPIRSF500063. DHAPAT. 1 hit.
PIRSF000437. GPAT_DHAPAT. 1 hit.
SMARTiSM00563. PlsC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGNPAT_BOVIN
AccessioniPrimary (citable) accession number: A4IF87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: May 1, 2007
Last modified: June 8, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.