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Protein

Tumor necrosis factor alpha-induced protein 8

Gene

TNFAIP8

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a negative mediator of apoptosis. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor alpha-induced protein 8
Short name:
TNF alpha-induced protein 8
Gene namesi
Name:TNFAIP8
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 7

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 198198Tumor necrosis factor alpha-induced protein 8PRO_0000331428Add
BLAST

Proteomic databases

PaxDbiA4IF78.
PRIDEiA4IF78.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000019342.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili49 – 8335Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the TNFAIP8 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEG9. Eukaryota.
ENOG4111KN4. LUCA.
GeneTreeiENSGT00390000003488.
HOGENOMiHOG000007708.
HOVERGENiHBG053286.
InParanoidiA4IF78.
OMAiSHGRINN.
OrthoDBiEOG7P5T2H.
TreeFamiTF323415.

Family and domain databases

InterProiIPR008477. DUF758.
[Graphical view]
PfamiPF05527. DUF758. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4IF78-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHFEAEESKE VATDVFNSKN LAVQAQKKIL GKMASKSIAT TLIDDTSSEV
60 70 80 90 100
LDELYRVTKE YTQNKKEAEK IIKNLIKTVI KLAILYRNNQ FNQDELALME
110 120 130 140 150
KFKKKVHQLA MTVVSFHQVD FTFDRNVLSK LLNECREMLH QIIQRHLTTK
160 170 180 190
SHGRVNNVFD HFSDCDFLAA LYNPFGNYKP HLQKLCDGIN KMLDEENI
Length:198
Mass (Da):22,995
Last modified:May 1, 2007 - v1
Checksum:i26D654CE82A6BFB1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC134442 mRNA. Translation: AAI34443.1.
RefSeqiNP_001077180.1. NM_001083711.2.
UniGeneiBt.36160.

Genome annotation databases

EnsembliENSBTAT00000019342; ENSBTAP00000019342; ENSBTAG00000014551.
GeneIDi529336.
KEGGibta:529336.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC134442 mRNA. Translation: AAI34443.1.
RefSeqiNP_001077180.1. NM_001083711.2.
UniGeneiBt.36160.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000019342.

Proteomic databases

PaxDbiA4IF78.
PRIDEiA4IF78.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000019342; ENSBTAP00000019342; ENSBTAG00000014551.
GeneIDi529336.
KEGGibta:529336.

Organism-specific databases

CTDi25816.

Phylogenomic databases

eggNOGiENOG410IEG9. Eukaryota.
ENOG4111KN4. LUCA.
GeneTreeiENSGT00390000003488.
HOGENOMiHOG000007708.
HOVERGENiHBG053286.
InParanoidiA4IF78.
OMAiSHGRINN.
OrthoDBiEOG7P5T2H.
TreeFamiTF323415.

Miscellaneous databases

NextBioi20875014.

Family and domain databases

InterProiIPR008477. DUF758.
[Graphical view]
PfamiPF05527. DUF758. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Thymus.

Entry informationi

Entry nameiTFIP8_BOVIN
AccessioniPrimary (citable) accession number: A4IF78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 1, 2007
Last modified: May 11, 2016
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.