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Protein

Tumor necrosis factor alpha-induced protein 8

Gene

TNFAIP8

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts as a negative mediator of apoptosis. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis

Enzyme and pathway databases

ReactomeiR-BTA-1483255 PI Metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor alpha-induced protein 8
Short name:
TNF alpha-induced protein 8
Gene namesi
Name:TNFAIP8
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 7

Organism-specific databases

VGNCiVGNC:36157 TNFAIP8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003314281 – 198Tumor necrosis factor alpha-induced protein 8Add BLAST198

Proteomic databases

PaxDbiA4IF78
PRIDEiA4IF78

Expressioni

Gene expression databases

BgeeiENSBTAG00000014551

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000019342

Structurei

3D structure databases

SMRiA4IF78
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili49 – 83Sequence analysisAdd BLAST35

Sequence similaritiesi

Belongs to the TNFAIP8 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEG9 Eukaryota
ENOG4111KN4 LUCA
GeneTreeiENSGT00390000003488
HOGENOMiHOG000007708
HOVERGENiHBG053286
InParanoidiA4IF78
OMAiRNNQFSE
OrthoDBiEOG091G0QQ9
TreeFamiTF323415

Family and domain databases

Gene3Di1.20.1440.160, 1 hit
InterProiView protein in InterPro
IPR008477 TNFAIP8-like
IPR038355 TNFAIP8_sf
PANTHERiPTHR12757 PTHR12757, 1 hit
PfamiView protein in Pfam
PF05527 DUF758, 1 hit

Sequencei

Sequence statusi: Complete.

A4IF78-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHFEAEESKE VATDVFNSKN LAVQAQKKIL GKMASKSIAT TLIDDTSSEV
60 70 80 90 100
LDELYRVTKE YTQNKKEAEK IIKNLIKTVI KLAILYRNNQ FNQDELALME
110 120 130 140 150
KFKKKVHQLA MTVVSFHQVD FTFDRNVLSK LLNECREMLH QIIQRHLTTK
160 170 180 190
SHGRVNNVFD HFSDCDFLAA LYNPFGNYKP HLQKLCDGIN KMLDEENI
Length:198
Mass (Da):22,995
Last modified:May 1, 2007 - v1
Checksum:i26D654CE82A6BFB1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC134442 mRNA Translation: AAI34443.1
RefSeqiNP_001077180.1, NM_001083711.2
UniGeneiBt.36160

Genome annotation databases

EnsembliENSBTAT00000019342; ENSBTAP00000019342; ENSBTAG00000014551
GeneIDi529336
KEGGibta:529336

Similar proteinsi

Entry informationi

Entry nameiTFIP8_BOVIN
AccessioniPrimary (citable) accession number: A4IF78
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 1, 2007
Last modified: March 28, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health