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Protein

NHL repeat-containing protein 2

Gene

NHLRC2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

ReactomeiR-BTA-114608 Platelet degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
NHL repeat-containing protein 2
Gene namesi
Name:NHLRC2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 26

Organism-specific databases

VGNCiVGNC:32068 NHLRC2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003138071 – 726NHL repeat-containing protein 2Add BLAST726

Proteomic databases

PaxDbiA4IF69
PRIDEiA4IF69

Expressioni

Gene expression databases

BgeeiENSBTAG00000003690

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004806

Structurei

3D structure databases

ProteinModelPortaliA4IF69
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati212 – 254NHL 1Add BLAST43
Repeati265 – 307NHL 2Add BLAST43
Repeati335 – 369NHL 3Add BLAST35
Repeati409 – 439NHL 4Add BLAST31
Repeati461 – 505NHL 5Add BLAST45
Repeati518 – 562NHL 6Add BLAST45

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410ITFZ Eukaryota
ENOG410XTIR LUCA
GeneTreeiENSGT00390000015483
HOGENOMiHOG000229147
HOVERGENiHBG059736
InParanoidiA4IF69
OMAiPWSCLFV
OrthoDBiEOG091G03QU
TreeFamiTF323628

Family and domain databases

Gene3Di2.120.10.30, 3 hits
InterProiView protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR000033 LDLR_classB_rpt
IPR001258 NHL_repeat
IPR013017 NHL_repeat_subgr
IPR012336 Thioredoxin-like_fold
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF01436 NHL, 4 hits
PF13905 Thioredoxin_8, 1 hit
SMARTiView protein in SMART
SM00135 LY, 2 hits
SUPFAMiSSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS51125 NHL, 4 hits

Sequencei

Sequence statusi: Complete.

A4IF69-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPGARSCN LSGLLPAQTS LEYALLDAVT QEEKDGLVYQ YLQKVDGWEQ
60 70 80 90 100
DLLVPEFPEG LEWLNTEEPI SVYKDLCGKV VILDFFTYCC INCIHLLPDL
110 120 130 140 150
HALEHTYSDK DGLLIVGVHS AKFPNEKVLD NIRSAVLRYN ITHPVVNDAD
160 170 180 190 200
ASLWQELEVS CWPTLIILGP RGNMLFSLIG EGHKEKLFLY TSIALKYYKD
210 220 230 240 250
RGQIRANKIG IKLYKDSLPP SPLLFPGKIT VDHVSNRLVI ADTGHHRILV
260 270 280 290 300
VWKNGQIQYS IGGPNPGRKD GIFSESSFNS PQGVAIMNNI IYVADTENHL
310 320 330 340 350
IRKIDLEAEM VSTVAGIGIQ GTDKEGGAKG DEQPISSPWD VVFGRSGPEV
360 370 380 390 400
QRDNILWIAM AGTHQIWALL LDCGRLPKKN ELKKGTCLRF AGSGNEENRN
410 420 430 440 450
NAYPHKAGFA QPSGLSLASE GPWSCLFVAD SESSTVRTVS LKDGAVKHLV
460 470 480 490 500
GGERDPMNLF AFGDVDGVGI NARLQHPLGV TWDQKRNLLY VADSYNHKIK
510 520 530 540 550
VVDPKTKNCT TLAGTGNASN MIGSSFTDST FNEPGGLCIG ENGQLLYVAD
560 570 580 590 600
TNNHQIKVLD LETKTVSVFP VFRSENAVVD GPCLAGKPKT LPKLPKSAPG
610 620 630 640 650
IRLAPVAASP GQTLQFKLRL DLPSGTKLTE GASSCWFLSA EGNEWLLQGQ
660 670 680 690 700
IPSGEIESIS NQPTISLQIP GDCLSLEAIL SISVFLYYCS SDSSACMMKG
710 720
ILFSQPLQIT DTQQDCIPPV ELKYIF
Length:726
Mass (Da):79,314
Last modified:May 1, 2007 - v1
Checksum:i1EE1809FC2B1DB0C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC134430 mRNA Translation: AAI34431.1
BC134671 mRNA Translation: AAI34672.1
RefSeqiNP_001077192.1, NM_001083723.2
UniGeneiBt.20833

Genome annotation databases

EnsembliENSBTAT00000004806; ENSBTAP00000004806; ENSBTAG00000003690
GeneIDi534327
KEGGibta:534327

Similar proteinsi

Entry informationi

Entry nameiNHLC2_BOVIN
AccessioniPrimary (citable) accession number: A4IF69
Secondary accession number(s): A7YWN6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 1, 2007
Last modified: March 28, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health