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Protein

NHL repeat-containing protein 2

Gene

NHLRC2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

ReactomeiR-BTA-114608. Platelet degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
NHL repeat-containing protein 2
Gene namesi
Name:NHLRC2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 26

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003138071 – 726NHL repeat-containing protein 2Add BLAST726

Proteomic databases

PaxDbiA4IF69.
PRIDEiA4IF69.

Expressioni

Gene expression databases

BgeeiENSBTAG00000003690.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004806.

Structurei

3D structure databases

ProteinModelPortaliA4IF69.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati212 – 254NHL 1Add BLAST43
Repeati265 – 307NHL 2Add BLAST43
Repeati335 – 369NHL 3Add BLAST35
Repeati409 – 439NHL 4Add BLAST31
Repeati461 – 505NHL 5Add BLAST45
Repeati518 – 562NHL 6Add BLAST45

Sequence similaritiesi

Contains 6 NHL repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410ITFZ. Eukaryota.
ENOG410XTIR. LUCA.
GeneTreeiENSGT00390000015483.
HOGENOMiHOG000229147.
HOVERGENiHBG059736.
InParanoidiA4IF69.
OMAiYCCINCL.
OrthoDBiEOG091G03QU.
TreeFamiTF323628.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR000033. LDLR_classB_rpt.
IPR001258. NHL_repeat.
IPR013017. NHL_repeat_subgr.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF01436. NHL. 4 hits.
PF13905. Thioredoxin_8. 1 hit.
[Graphical view]
SMARTiSM00135. LY. 2 hits.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS51125. NHL. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4IF69-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPGARSCN LSGLLPAQTS LEYALLDAVT QEEKDGLVYQ YLQKVDGWEQ
60 70 80 90 100
DLLVPEFPEG LEWLNTEEPI SVYKDLCGKV VILDFFTYCC INCIHLLPDL
110 120 130 140 150
HALEHTYSDK DGLLIVGVHS AKFPNEKVLD NIRSAVLRYN ITHPVVNDAD
160 170 180 190 200
ASLWQELEVS CWPTLIILGP RGNMLFSLIG EGHKEKLFLY TSIALKYYKD
210 220 230 240 250
RGQIRANKIG IKLYKDSLPP SPLLFPGKIT VDHVSNRLVI ADTGHHRILV
260 270 280 290 300
VWKNGQIQYS IGGPNPGRKD GIFSESSFNS PQGVAIMNNI IYVADTENHL
310 320 330 340 350
IRKIDLEAEM VSTVAGIGIQ GTDKEGGAKG DEQPISSPWD VVFGRSGPEV
360 370 380 390 400
QRDNILWIAM AGTHQIWALL LDCGRLPKKN ELKKGTCLRF AGSGNEENRN
410 420 430 440 450
NAYPHKAGFA QPSGLSLASE GPWSCLFVAD SESSTVRTVS LKDGAVKHLV
460 470 480 490 500
GGERDPMNLF AFGDVDGVGI NARLQHPLGV TWDQKRNLLY VADSYNHKIK
510 520 530 540 550
VVDPKTKNCT TLAGTGNASN MIGSSFTDST FNEPGGLCIG ENGQLLYVAD
560 570 580 590 600
TNNHQIKVLD LETKTVSVFP VFRSENAVVD GPCLAGKPKT LPKLPKSAPG
610 620 630 640 650
IRLAPVAASP GQTLQFKLRL DLPSGTKLTE GASSCWFLSA EGNEWLLQGQ
660 670 680 690 700
IPSGEIESIS NQPTISLQIP GDCLSLEAIL SISVFLYYCS SDSSACMMKG
710 720
ILFSQPLQIT DTQQDCIPPV ELKYIF
Length:726
Mass (Da):79,314
Last modified:May 1, 2007 - v1
Checksum:i1EE1809FC2B1DB0C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC134430 mRNA. Translation: AAI34431.1.
BC134671 mRNA. Translation: AAI34672.1.
RefSeqiNP_001077192.1. NM_001083723.2.
UniGeneiBt.20833.

Genome annotation databases

EnsembliENSBTAT00000004806; ENSBTAP00000004806; ENSBTAG00000003690.
GeneIDi534327.
KEGGibta:534327.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC134430 mRNA. Translation: AAI34431.1.
BC134671 mRNA. Translation: AAI34672.1.
RefSeqiNP_001077192.1. NM_001083723.2.
UniGeneiBt.20833.

3D structure databases

ProteinModelPortaliA4IF69.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004806.

Proteomic databases

PaxDbiA4IF69.
PRIDEiA4IF69.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000004806; ENSBTAP00000004806; ENSBTAG00000003690.
GeneIDi534327.
KEGGibta:534327.

Organism-specific databases

CTDi374354.

Phylogenomic databases

eggNOGiENOG410ITFZ. Eukaryota.
ENOG410XTIR. LUCA.
GeneTreeiENSGT00390000015483.
HOGENOMiHOG000229147.
HOVERGENiHBG059736.
InParanoidiA4IF69.
OMAiYCCINCL.
OrthoDBiEOG091G03QU.
TreeFamiTF323628.

Enzyme and pathway databases

ReactomeiR-BTA-114608. Platelet degranulation.

Gene expression databases

BgeeiENSBTAG00000003690.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR000033. LDLR_classB_rpt.
IPR001258. NHL_repeat.
IPR013017. NHL_repeat_subgr.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF01436. NHL. 4 hits.
PF13905. Thioredoxin_8. 1 hit.
[Graphical view]
SMARTiSM00135. LY. 2 hits.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS51125. NHL. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNHLC2_BOVIN
AccessioniPrimary (citable) accession number: A4IF69
Secondary accession number(s): A7YWN6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 1, 2007
Last modified: October 5, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.