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Protein

Solute carrier family 35 member F4

Gene

SLC35F4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Putative solute transporter.Curated

GO - Biological processi

Keywordsi

Biological processTransport

Protein family/group databases

TCDBi2.A.7.24.14. the drug/metabolite transporter (dmt) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 35 member F4
Gene namesi
Name:SLC35F4
Synonyms:C14orf36
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000151812.14.
HGNCiHGNC:19845. SLC35F4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Transmembranei192 – 212HelicalSequence analysisAdd BLAST21
Transmembranei248 – 266HelicalSequence analysisAdd BLAST19
Transmembranei277 – 297HelicalSequence analysisAdd BLAST21
Transmembranei301 – 321HelicalSequence analysisAdd BLAST21
Transmembranei330 – 350HelicalSequence analysisAdd BLAST21
Transmembranei365 – 385HelicalSequence analysisAdd BLAST21
Transmembranei395 – 417HelicalSequence analysisAdd BLAST23
Transmembranei419 – 441HelicalSequence analysisAdd BLAST23
Transmembranei450 – 470HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000151812.
PharmGKBiPA134959551.

Polymorphism and mutation databases

BioMutaiSLC35F4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003119651 – 521Solute carrier family 35 member F4Add BLAST521

Proteomic databases

PaxDbiA4IF30.
PRIDEiA4IF30.

Expressioni

Gene expression databases

BgeeiENSG00000151812.
CleanExiHS_SLC35F4.
ExpressionAtlasiA4IF30. baseline and differential.
GenevisibleiA4IF30. HS.

Organism-specific databases

HPAiHPA043853.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000342518.

Structurei

3D structure databases

ProteinModelPortaliA4IF30.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini261 – 321EamAAdd BLAST61

Sequence similaritiesi

Belongs to the SLC35F solute transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4314. Eukaryota.
ENOG410YZVZ. LUCA.
GeneTreeiENSGT00390000008727.
HOGENOMiHOG000060188.
HOVERGENiHBG108446.
InParanoidiA4IF30.
KOiK15288.
OMAiANCPSSH.
OrthoDBiEOG091G070X.
PhylomeDBiA4IF30.
TreeFamiTF313798.

Family and domain databases

InterProiView protein in InterPro
IPR009262. SLC35_F1/F2/F6.
IPR026505. Solute_c_fam_35_mem_F3/F4.
PANTHERiPTHR19346. PTHR19346. 1 hit.
PfamiView protein in Pfam
PF06027. SLC35F. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A4IF30-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDELLLDLFH KLTSGRQLAA GNGLCGISHK EQEVWKPGHN ILVKMRKEDK
60 70 80 90 100
SLVWLIHSTL ARYTQVTNFL GTSRSSVTRC KPGANCPSSH SGISRQLSPL
110 120 130 140 150
SVTEDSSAPI LELQNQGSSG VCGHRVERQN RSADDGTQTH SENSSQENRI
160 170 180 190 200
KARCLSCTSM VLKGIWGLLI ILSVSSSWVG TTQIVKITYK NFYCPFFMTW
210 220 230 240 250
FSTNWNIMFF PVYYSGHLAT AQEKQSPMKK FRECSRIFGE DGLTLKLFLK
260 270 280 290 300
RTAPFSILWT LTNYLYLLAL KKLTATDVSA LFCCNKAFVF LLSWIVLKDR
310 320 330 340 350
FMGVRIVAAI MAITGIVMMA YADNFHADSI IGVAFAVGSA STSALYKVLF
360 370 380 390 400
KMFLGSANFG EAAHFVSTLG FFNLIFISFT PVILYFTKVE HWSSFAALPW
410 420 430 440 450
GCLCGMAGLW LAFNILVNVG VVLTYPILIS IGTVLSVPGN AAVDLLKQEV
460 470 480 490 500
IFNVVRLAAT IIICIGFLLM LLPEEWDEIT LRFINSLKEK KSEEHVDDVT
510 520
DPSIHLRGRG RANGTVSIPL A
Length:521
Mass (Da):57,809
Last modified:December 4, 2007 - v2
Checksum:i8509C6BAB218E5B8
GO
Isoform 2 (identifier: A4IF30-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-159: Missing.

Note: No experimental confirmation available.
Show »
Length:362
Mass (Da):40,399
Checksum:i870BCC605B8CDC02
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0296691 – 159Missing in isoform 2. 1 PublicationAdd BLAST159

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136520 Genomic DNA. No translation available.
AL161804 Genomic DNA. No translation available.
BC101318 mRNA. Translation: AAI01319.1.
BC101320 mRNA. Translation: AAI01321.1.
BC101321 mRNA. Translation: AAI01322.1.
RefSeqiNP_001193849.1. NM_001206920.1.
NP_001293016.1. NM_001306087.1.
XP_011535027.1. XM_011536725.1.
XP_016876749.1. XM_017021260.1. [A4IF30-2]
UniGeneiHs.28280.

Genome annotation databases

EnsembliENST00000339762; ENSP00000342518; ENSG00000151812. [A4IF30-1]
ENST00000554729; ENSP00000451990; ENSG00000151812. [A4IF30-2]
GeneIDi341880.
KEGGihsa:341880.
UCSCiuc010apa.2. human. [A4IF30-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiS35F4_HUMAN
AccessioniPrimary (citable) accession number: A4IF30
Secondary accession number(s): A6NDQ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 4, 2007
Last modified: November 22, 2017
This is version 75 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families