ID   A4IAZ4_LEIIN            Unreviewed;       371 AA.
AC   A4IAZ4; A0A2K4Z647; A0A381MUB4;
DT   01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2007, sequence version 1.
DT   24-JAN-2024, entry version 82.
DE   SubName: Full=Putative aldose 1-epimerase {ECO:0000313|EMBL:CAM72006.1};
DE            EC=5.1.3.3 {ECO:0000313|EMBL:CAM72006.1};
GN   ORFNames=LINJ_35_0990 {ECO:0000313|EMBL:CAM72006.1};
OS   Leishmania infantum.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX   NCBI_TaxID=5671 {ECO:0000313|EMBL:CAM72006.1, ECO:0000313|Proteomes:UP000008153};
RN   [1] {ECO:0000313|EMBL:CAM72006.1, ECO:0000313|Proteomes:UP000008153}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JPCM5 {ECO:0000313|EMBL:CAM72006.1,
RC   ECO:0000313|Proteomes:UP000008153};
RX   PubMed=17572675; DOI=10.1038/ng2053;
RA   Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA   Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA   Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA   Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA   Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA   Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA   Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA   Mottram J.C., Smith D.F., Berriman M.;
RT   "Comparative genomic analysis of three Leishmania species that cause
RT   diverse human disease.";
RL   Nat. Genet. 39:839-847(2007).
RN   [2] {ECO:0000313|EMBL:CAM72006.1, ECO:0000313|Proteomes:UP000008153}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JPCM5 {ECO:0000313|EMBL:CAM72006.1,
RC   ECO:0000313|Proteomes:UP000008153};
RX   PubMed=22038252; DOI=10.1101/gr.122945.111;
RA   Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA   Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA   Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA   Hertz-Fowler C., Mottram J.C.;
RT   "Chromosome and gene copy number variation allow major structural change
RT   between species and strains of Leishmania.";
RL   Genome Res. 21:2129-2142(2011).
CC   -!- SIMILARITY: Belongs to the aldose epimerase family.
CC       {ECO:0000256|ARBA:ARBA00006206}.
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DR   EMBL; FR796467; CAM72006.1; -; Genomic_DNA.
DR   RefSeq; XP_001468913.1; XM_001468876.1.
DR   AlphaFoldDB; A4IAZ4; -.
DR   SMR; A4IAZ4; -.
DR   STRING; 5671.A4IAZ4; -.
DR   GeneID; 5072998; -.
DR   KEGG; lif:LINJ_35_0990; -.
DR   VEuPathDB; TriTrypDB:LINF_350014400; -.
DR   eggNOG; KOG1604; Eukaryota.
DR   InParanoid; A4IAZ4; -.
DR   OMA; TNHTYFG; -.
DR   OrthoDB; 158384at2759; -.
DR   Proteomes; UP000008153; Chromosome 35.
DR   GO; GO:0004034; F:aldose 1-epimerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   CDD; cd09019; galactose_mutarotase_like; 1.
DR   Gene3D; 2.70.98.10; -; 1.
DR   InterPro; IPR008183; Aldose_1/G6P_1-epimerase.
DR   InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR   InterPro; IPR047215; Galactose_mutarotase-like.
DR   InterPro; IPR014718; GH-type_carb-bd.
DR   PANTHER; PTHR10091; ALDOSE-1-EPIMERASE; 1.
DR   PANTHER; PTHR10091:SF0; GALACTOSE MUTAROTASE; 1.
DR   Pfam; PF01263; Aldose_epim; 1.
DR   SUPFAM; SSF74650; Galactose mutarotase-like; 1.
PE   3: Inferred from homology;
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:CAM72006.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008153}.
SQ   SEQUENCE   371 AA;  41517 MW;  FFB5287DE0ABA452 CRC64;
     MQFGIRVEPY GYDKLVWLET DVLKVGLTNY AASVASIQVY HPADNKWIEV NCGYPKNPEE
     AYADPDYMGA TVGRCAGRVA GGVFTLDGVK YYTQKNRGEN TCHCGDDAYH KKHWGMKLIE
     TANVIGVRFN YTSPHMESGF PGEVKNYCTF IIDRSNPNAL KTIYDSYITD NSPCDASPIN
     VFSHTSFNLN GIPGQQDGEK NWVQPESVRN HWLRVPASRV AEADRMAIPT GEFLSVEGTG
     LDFRQGRVIG DCIDDVALLD RDPCGYDHPL AIDGWEKGKL MLHAEAKSPV TNICMKVYST
     FPCMWVYTAN NKPLPASGGP GQRYARWTGL LVGPQNFSDV ANYYPKYPSC IVRRGERQYS
     ETTINEFTIE H
//