A4I7H1 (A4I7H1_LEIIN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Glycylpeptide N-tetradecanoyltransferase RuleBase RU000586
EC=2.3.1.97 RuleBase RU000586

Gene names

Name:	NMT EMBL CAM70755.1
ORF Names:	LINJ_32_0080 EMBL CAM70755.1

Organism

Leishmania infantum

Taxonomic identifier

5671 [NCBI]

Taxonomic lineage

Eukaryota › Euglenozoa › Kinetoplastida › Trypanosomatidae › Leishmania

Protein attributes

Sequence length	421 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins By similarity. RuleBase RU000586
Catalytic activity	Tetradecanoyl-CoA + glycylpeptide = CoA + N-tetradecanoylglycylpeptide. RuleBase RU000586
Sequence similarities	Belongs to the NMT family. RuleBase RU004178

Ontologies

Keywords
Molecular function	Acyltransferase RuleBase RU000586 EMBL CAM70755.1 Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	N-terminal protein myristoylation Inferred from electronic annotation. Source: InterPro
Molecular function	glycylpeptide N-tetradecanoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A4I7H1 [UniParc]. Last modified May 1, 2007. Version 1. Checksum: CFC990F7DB17CCB4	FASTA	421	48,601
	10 20 30 40 50 60 MSRNPSNSDA AHAFWSTQPV PQTEDETEKI VFAGPMDEPK TVADIPEEPY PIASTFEWWT 70 80 90 100 110 120 PNMEAADDIH AIYELLRDNY VEDDDSMFRF NYSEEFLQWA LCPPSYIPDW HVAVRRKADK 130 140 150 160 170 180 KLLAFIAGVP VTLRMGTPKY MKVKAQEKGQ EEEAAKYDAP RHICEINFLC VHKQLREKRL 190 200 210 220 230 240 APILIKEVTR RVNRTNVWQA VYTAGVLLPT PYASGQYFHR SLNPEKLVEI RFSGIPAQYQ 250 260 270 280 290 300 KFQNPMAMLK RNYQLPNAPK NSGLREMKPS DVPQVRRILM NYLDNFDVGP VFSDAEISHY 310 320 330 340 350 360 LLPRDGVVFT YVVENDKKVT DFFSFYRIPS TVIGNSNYNI LNAAYVHYYA ATSMPLHQLI 370 380 390 400 410 420 LDLLIVAHSR GFDVCNMVEI LDNRSFVEQL KFGAGDGHLR YYFYNWAYPK IKPSQVALVM L

References

[1]

"Comparative genomic analysis of three Leishmania species that cause diverse human disease." Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A., Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A., Fraser A., Rajandream M.-A., Carver T., Norbertczak H., Chillingworth T., Hance Z. , Jagels K., Moule S., Ormond D., Rutter S., Sqaures R., Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S., Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P., Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R.O., Barrell B., Cruz A.K., Mottram J.C., Smith D.F., Berriman M. Nat. Genet. 39:839-847(2007) [PubMed: 17572675] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	FR796464 Genomic DNA. Translation: CAM70755.1.
RefSeq	XP_001467690.1. XM_001467653.1.
3D structure databases
ProteinModelPortal	A4I7H1.
ModBase	Search...
Protein-protein interaction databases
STRING	A4I7H1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5071748.
KEGG	lif:LINJ_32_0080.
Phylogenomic databases
eggNOG	KOG2779.
HOGENOM	HBG314670.
OMA	EHAKGSP.
PhylomeDB	A4I7H1.
ProtClustDB	CLSZ2428978.
Family and domain databases
InterPro	IPR016181. Acyl_CoA_acyltransferase. IPR000903. MyristoylCoA_TrFase. IPR022677. MyristoylCoA_TrFase_C. IPR022678. MyristoylCoA_TrFase_CS. IPR022676. MyristoylCoA_TrFase_N. [Graphical view]
Gene3D	G3DSA:3.40.630.30. Acyl_CoA_acyltransferase. 2 hits.
KO	K00671.
PANTHER	PTHR11377. Myristoyl_trans. 1 hit.
Pfam	PF01233. NMT. 1 hit. PF02799. NMT_C. 1 hit. [Graphical view]
PIRSF	PIRSF015892. N-myristl_transf. 1 hit.
SUPFAM	SSF55729. Acyl_CoA_acyltransferase. 2 hits.
PROSITE	PS00975. NMT_1. 1 hit. PS00976. NMT_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A4I7H1_LEIIN

Accession

Primary (citable) accession number: A4I7H1

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2007
Last sequence update:	May 1, 2007
Last modified:	December 14, 2011
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)