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Protein

DNA ligase

Gene

LINJ_30_3490

Organism
Leishmania infantum
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA biosynthetic process Source: InterPro
  2. DNA ligation involved in DNA repair Source: InterPro
  3. DNA recombination Source: UniProtKB-KW
  4. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
ORF Names:LINJ_30_3490Imported
OrganismiLeishmania infantumImported
Taxonomic identifieri5671 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania
ProteomesiUP000008153: Chromosome 30

Interactioni

Protein-protein interaction databases

STRINGi5671.LinJ30.3920.

Structurei

3D structure databases

ProteinModelPortaliA4I634.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1793.
InParanoidiA4I634.
KOiK10747.
OMAiPQVVIEV.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4I634-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKLFQESSF DPVTTFEAVW LPPRVPVAPP TAGASEPVPF AAVVDVLADI
60 70 80 90 100
SATGSRLECL KQLTFLLLAV IERCPEDLVP VMYLVINKHA PQHEGVELGI
110 120 130 140 150
GDAVLVKAVA ECCGMTEARA KEAYRQSGDL AEIAQMHKQK QSTLMKPKPL
160 170 180 190 200
SARSVFKTYK EIAMMSGRDV MRRRSDLIKG LLRDAQGPEV NLIVRGLQQK
210 220 230 240 250
MRIGLAEPSA LAAVGYAFAL HFLGGAQMHK MDEVQLQTLL NTGADSLARI
260 270 280 290 300
FYEVPSLDVV LSAVLANGFM TLVPGSSIAK RYAKDLSIRP GLPVKPQLAY
310 320 330 340 350
PTSSITVILD RLQGKKFTSE YKYDGERAQI HYDKDKGFHI FSRNSETHTG
360 370 380 390 400
KYPDVISMLP KVFDPVEVQS FILDSEVVAV HPETGALQAF QVLQHRGRKN
410 420 430 440 450
IAEEDVSIPV CVFVFDILYF NGEPQLNKTL QQRRELLWRC IHPLPAKLSF
460 470 480 490 500
ATYLDSDKVE DMQTFLERSI ADGCEGLMVK TLDEEANYTP AKRSHYWLKL
510 520 530 540 550
KKDYMDGVTD TLDLVPIAAF HGKGKRTGVF GGFLLACYDP KADEYQSICK
560 570 580 590 600
IGTGFQDEEL EKLTQSLKPF VVDDKPRYYR AGGEEPDVWL TEAQVWEVKA
610 620 630 640 650
ADLSVSPVHQ AAVGLVDPSK GIALRFPRYL RQREDKKPAD ATNAQQVADM
660
YKAQSLAVQH EANGDAE
Length:667
Mass (Da):74,064
Last modified:May 1, 2007 - v1
Checksum:iDAC701EBA6D3049F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR796462 Genomic DNA. Translation: CAM70256.1.
RefSeqiXP_001467203.1. XM_001467166.1.

Genome annotation databases

GeneIDi5071249.
KEGGilif:LINJ_30_3490.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR796462 Genomic DNA. Translation: CAM70256.1.
RefSeqiXP_001467203.1. XM_001467166.1.

3D structure databases

ProteinModelPortaliA4I634.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5671.LinJ30.3920.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5071249.
KEGGilif:LINJ_30_3490.

Phylogenomic databases

eggNOGiCOG1793.
InParanoidiA4I634.
KOiK10747.
OMAiPQVVIEV.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JPCM5Imported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JPCM5Imported.

Entry informationi

Entry nameiA4I634_LEIIN
AccessioniPrimary (citable) accession number: A4I634
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2007
Last sequence update: May 1, 2007
Last modified: January 7, 2015
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.