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Protein

DNA ligase

Gene

LINJ_30_3490

Organism
Leishmania infantum
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processDNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
ORF Names:LINJ_30_3490Imported
OrganismiLeishmania infantumImported
Taxonomic identifieri5671 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania
Proteomesi
  • UP000008153 Componenti: Chromosome 30

Organism-specific databases

EuPathDBiTriTrypDB:LinJ.30.3490

Interactioni

Protein-protein interaction databases

STRINGi435258.XP_001467203.1

Structurei

3D structure databases

ProteinModelPortaliA4I634
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini403 – 539DNA_LIGASE_A3InterPro annotationAdd BLAST137

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0967 Eukaryota
COG1793 LUCA
InParanoidiA4I634
KOiK10747
OMAiWIKYKRD

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
InterProiView protein in InterPro
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS00333 DNA_LIGASE_A2, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

A4I634-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKLFQESSF DPVTTFEAVW LPPRVPVAPP TAGASEPVPF AAVVDVLADI
60 70 80 90 100
SATGSRLECL KQLTFLLLAV IERCPEDLVP VMYLVINKHA PQHEGVELGI
110 120 130 140 150
GDAVLVKAVA ECCGMTEARA KEAYRQSGDL AEIAQMHKQK QSTLMKPKPL
160 170 180 190 200
SARSVFKTYK EIAMMSGRDV MRRRSDLIKG LLRDAQGPEV NLIVRGLQQK
210 220 230 240 250
MRIGLAEPSA LAAVGYAFAL HFLGGAQMHK MDEVQLQTLL NTGADSLARI
260 270 280 290 300
FYEVPSLDVV LSAVLANGFM TLVPGSSIAK RYAKDLSIRP GLPVKPQLAY
310 320 330 340 350
PTSSITVILD RLQGKKFTSE YKYDGERAQI HYDKDKGFHI FSRNSETHTG
360 370 380 390 400
KYPDVISMLP KVFDPVEVQS FILDSEVVAV HPETGALQAF QVLQHRGRKN
410 420 430 440 450
IAEEDVSIPV CVFVFDILYF NGEPQLNKTL QQRRELLWRC IHPLPAKLSF
460 470 480 490 500
ATYLDSDKVE DMQTFLERSI ADGCEGLMVK TLDEEANYTP AKRSHYWLKL
510 520 530 540 550
KKDYMDGVTD TLDLVPIAAF HGKGKRTGVF GGFLLACYDP KADEYQSICK
560 570 580 590 600
IGTGFQDEEL EKLTQSLKPF VVDDKPRYYR AGGEEPDVWL TEAQVWEVKA
610 620 630 640 650
ADLSVSPVHQ AAVGLVDPSK GIALRFPRYL RQREDKKPAD ATNAQQVADM
660
YKAQSLAVQH EANGDAE
Length:667
Mass (Da):74,064
Last modified:May 1, 2007 - v1
Checksum:iDAC701EBA6D3049F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR796462 Genomic DNA Translation: CAM70256.1
RefSeqiXP_001467203.1, XM_001467166.1

Genome annotation databases

EnsemblProtistsiCAM70256; CAM70256; LINJ_30_3490
GeneDBiLinJ.30.3490:pep
GeneIDi5071249
KEGGilif:LINJ_30_3490

Similar proteinsi

Entry informationi

Entry nameiA4I634_LEIIN
AccessioniPrimary (citable) accession number: A4I634
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2007
Last sequence update: May 1, 2007
Last modified: April 25, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health