ID   A4I0X6_LEIIN            Unreviewed;       536 AA.
AC   A4I0X6; A0A381MIS2;
DT   01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2007, sequence version 1.
DT   27-MAR-2024, entry version 96.
DE   RecName: Full=histone deacetylase {ECO:0000256|ARBA:ARBA00012111};
DE            EC=3.5.1.98 {ECO:0000256|ARBA:ARBA00012111};
GN   ORFNames=LINJ_24_1410 {ECO:0000313|EMBL:CAM68400.1};
OS   Leishmania infantum.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX   NCBI_TaxID=5671 {ECO:0000313|EMBL:CAM68400.1, ECO:0000313|Proteomes:UP000008153};
RN   [1] {ECO:0000313|EMBL:CAM68400.1, ECO:0000313|Proteomes:UP000008153}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JPCM5 {ECO:0000313|EMBL:CAM68400.1,
RC   ECO:0000313|Proteomes:UP000008153};
RX   PubMed=17572675; DOI=10.1038/ng2053;
RA   Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA   Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA   Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA   Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA   Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA   Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA   Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA   Mottram J.C., Smith D.F., Berriman M.;
RT   "Comparative genomic analysis of three Leishmania species that cause
RT   diverse human disease.";
RL   Nat. Genet. 39:839-847(2007).
RN   [2] {ECO:0000313|EMBL:CAM68400.1, ECO:0000313|Proteomes:UP000008153}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JPCM5 {ECO:0000313|EMBL:CAM68400.1,
RC   ECO:0000313|Proteomes:UP000008153};
RX   PubMed=22038252; DOI=10.1101/gr.122945.111;
RA   Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA   Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA   Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA   Hertz-Fowler C., Mottram J.C.;
RT   "Chromosome and gene copy number variation allow major structural change
RT   between species and strains of Leishmania.";
RL   Genome Res. 21:2129-2142(2011).
CC   -!- SIMILARITY: Belongs to the histone deacetylase family. HD type 1
CC       subfamily. {ECO:0000256|ARBA:ARBA00006457}.
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DR   EMBL; FR796456; CAM68400.1; -; Genomic_DNA.
DR   RefSeq; XP_001465967.1; XM_001465930.1.
DR   AlphaFoldDB; A4I0X6; -.
DR   SMR; A4I0X6; -.
DR   STRING; 5671.A4I0X6; -.
DR   GeneID; 5069396; -.
DR   KEGG; lif:LINJ_24_1410; -.
DR   VEuPathDB; TriTrypDB:LINF_240019100; -.
DR   eggNOG; KOG1342; Eukaryota.
DR   InParanoid; A4I0X6; -.
DR   OMA; GWLRAFH; -.
DR   OrthoDB; 168126at2759; -.
DR   Proteomes; UP000008153; Chromosome 24.
DR   GO; GO:0004407; F:histone deacetylase activity; IEA:UniProtKB-EC.
DR   CDD; cd09991; HDAC_classI; 1.
DR   Gene3D; 3.40.800.20; Histone deacetylase domain; 1.
DR   InterPro; IPR000286; His_deacetylse.
DR   InterPro; IPR003084; His_deacetylse_1.
DR   InterPro; IPR023801; His_deacetylse_dom.
DR   InterPro; IPR037138; His_deacetylse_dom_sf.
DR   InterPro; IPR023696; Ureohydrolase_dom_sf.
DR   PANTHER; PTHR10625:SF13; HISTONE DEACETYLASE HDAC1; 1.
DR   PANTHER; PTHR10625; HISTONE DEACETYLASE HDAC1-RELATED; 1.
DR   Pfam; PF00850; Hist_deacetyl; 1.
DR   PRINTS; PR01270; HDASUPER.
DR   PRINTS; PR01271; HISDACETLASE.
DR   SUPFAM; SSF52768; Arginase/deacetylase; 1.
PE   3: Inferred from homology;
KW   Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008153}.
FT   DOMAIN          102..402
FT                   /note="Histone deacetylase"
FT                   /evidence="ECO:0000259|Pfam:PF00850"
SQ   SEQUENCE   536 AA;  58127 MW;  28DEB24A4A029B71 CRC64;
     MSTPEQLPAL SAAGSPSSGG ASSHHSPHEA SLSFPASVIP GDASAESPRA WSMPRSSTAS
     EESAATSQLQ QKPDAPESRL GGRKVVYFVD HSVTSIAYAE GHLMRPSRVR ALHALVHSLG
     LDNAECMTVC HARPATAEEM GAFHRSAYLE CLRQAPVICG NPLDEMSLAF QKEFDVPFAS
     QNGDCPLFPE VWALVSSQAG ASLACAEALV RGDATVAMNW AGGMHHAAAA HASGFCFVND
     IVLCIRRLLR HYQRVLYVDL DVHHGDGVEG AFYGNHRVMT LSLHQFGNGF FPGTGDYPTR
     ETADSFAINV PLPTRTGDAA YLLSFRTALS SVVQCFDPEA MVVQCGADTI AGDLIGRLCV
     TTLAHTQCVA DVLSLERPTV LLGGGGYHVF HTARCWAIHT ATALGRTAAQ LPLYIPRTDP
     YYMDYRRECT PKRPTLHVFL DPDVDDPLPL GDSLAFWRQL CRSIQWQMRA ARLVRQGFFR
     TLQLCRQRRA ALLRQFATQE AGRESGIGVS GPKRPRSANA TDRDAKEGVE DRVVSA
//