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A4I0X6

- A4I0X6_LEIIN

UniProt

A4I0X6 - A4I0X6_LEIIN

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Protein

Histone deacetylase

Gene

LINJ_24_1410

Organism
Leishmania infantum
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotation

GO - Molecular functioni

  1. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
  2. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
  3. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
  4. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, HydrolaseUniRule annotationSAAS annotation

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseUniRule annotation (EC:3.5.1.98UniRule annotation)
Gene namesi
ORF Names:LINJ_24_1410Imported
OrganismiLeishmania infantumImported
Taxonomic identifieri5671 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania
ProteomesiUP000008153: Chromosome 24

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi5671.LinJ24.1050.

Structurei

3D structure databases

ProteinModelPortaliA4I0X6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone deacetylase family. HD Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0123.
InParanoidiA4I0X6.
KOiK06067.
OMAiCHARPAT.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.

Sequencei

Sequence statusi: Complete.

A4I0X6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTPEQLPAL SAAGSPSSGG ASSHHSPHEA SLSFPASVIP GDASAESPRA
60 70 80 90 100
WSMPRSSTAS EESAATSQLQ QKPDAPESRL GGRKVVYFVD HSVTSIAYAE
110 120 130 140 150
GHLMRPSRVR ALHALVHSLG LDNAECMTVC HARPATAEEM GAFHRSAYLE
160 170 180 190 200
CLRQAPVICG NPLDEMSLAF QKEFDVPFAS QNGDCPLFPE VWALVSSQAG
210 220 230 240 250
ASLACAEALV RGDATVAMNW AGGMHHAAAA HASGFCFVND IVLCIRRLLR
260 270 280 290 300
HYQRVLYVDL DVHHGDGVEG AFYGNHRVMT LSLHQFGNGF FPGTGDYPTR
310 320 330 340 350
ETADSFAINV PLPTRTGDAA YLLSFRTALS SVVQCFDPEA MVVQCGADTI
360 370 380 390 400
AGDLIGRLCV TTLAHTQCVA DVLSLERPTV LLGGGGYHVF HTARCWAIHT
410 420 430 440 450
ATALGRTAAQ LPLYIPRTDP YYMDYRRECT PKRPTLHVFL DPDVDDPLPL
460 470 480 490 500
GDSLAFWRQL CRSIQWQMRA ARLVRQGFFR TLQLCRQRRA ALLRQFATQE
510 520 530
AGRESGIGVS GPKRPRSANA TDRDAKEGVE DRVVSA
Length:536
Mass (Da):58,127
Last modified:May 1, 2007 - v1
Checksum:i28DEB24A4A029B71
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR796456 Genomic DNA. Translation: CAM68400.1.
RefSeqiXP_001465967.1. XM_001465930.1.

Genome annotation databases

GeneIDi5069396.
KEGGilif:LINJ_24_1410.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR796456 Genomic DNA. Translation: CAM68400.1 .
RefSeqi XP_001465967.1. XM_001465930.1.

3D structure databases

ProteinModelPortali A4I0X6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5671.LinJ24.1050.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5069396.
KEGGi lif:LINJ_24_1410.

Phylogenomic databases

eggNOGi COG0123.
InParanoidi A4I0X6.
KOi K06067.
OMAi CHARPAT.

Family and domain databases

Gene3Di 3.40.800.20. 1 hit.
InterProi IPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view ]
PANTHERi PTHR10625. PTHR10625. 1 hit.
Pfami PF00850. Hist_deacetyl. 1 hit.
[Graphical view ]
PIRSFi PIRSF037913. His_deacetylse_1. 1 hit.
PRINTSi PR01270. HDASUPER.
PR01271. HISDACETLASE.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JPCM5Imported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JPCM5Imported.

Entry informationi

Entry nameiA4I0X6_LEIIN
AccessioniPrimary (citable) accession number: A4I0X6
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2007
Last sequence update: May 1, 2007
Last modified: October 29, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3