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A4I0X6

- A4I0X6_LEIIN

UniProt

A4I0X6 - A4I0X6_LEIIN

Protein

Histone deacetylase

Gene

LINJ_24_1410

Organism
Leishmania infantum
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (01 May 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotation

    GO - Molecular functioni

    1. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
    2. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
    3. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
    4. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulatorUniRule annotation, HydrolaseUniRule annotationSAAS annotation

    Keywords - Biological processi

    Transcription, Transcription regulationUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone deacetylaseUniRule annotation (EC:3.5.1.98UniRule annotation)
    Gene namesi
    ORF Names:LINJ_24_1410Imported
    OrganismiLeishmania infantumImported
    Taxonomic identifieri5671 [NCBI]
    Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania
    ProteomesiUP000008153: Chromosome 24

    Subcellular locationi

    Nucleus UniRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    NucleusUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi5671.LinJ24.1050.

    Structurei

    3D structure databases

    ProteinModelPortaliA4I0X6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histone deacetylase family. HD Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0123.
    KOiK06067.
    OMAiCHARPAT.

    Family and domain databases

    Gene3Di3.40.800.20. 1 hit.
    InterProiIPR000286. His_deacetylse.
    IPR003084. His_deacetylse_1.
    IPR023801. His_deacetylse_dom.
    [Graphical view]
    PANTHERiPTHR10625. PTHR10625. 1 hit.
    PfamiPF00850. Hist_deacetyl. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
    PRINTSiPR01270. HDASUPER.
    PR01271. HISDACETLASE.

    Sequencei

    Sequence statusi: Complete.

    A4I0X6-1 [UniParc]FASTAAdd to Basket

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    MSTPEQLPAL SAAGSPSSGG ASSHHSPHEA SLSFPASVIP GDASAESPRA    50
    WSMPRSSTAS EESAATSQLQ QKPDAPESRL GGRKVVYFVD HSVTSIAYAE 100
    GHLMRPSRVR ALHALVHSLG LDNAECMTVC HARPATAEEM GAFHRSAYLE 150
    CLRQAPVICG NPLDEMSLAF QKEFDVPFAS QNGDCPLFPE VWALVSSQAG 200
    ASLACAEALV RGDATVAMNW AGGMHHAAAA HASGFCFVND IVLCIRRLLR 250
    HYQRVLYVDL DVHHGDGVEG AFYGNHRVMT LSLHQFGNGF FPGTGDYPTR 300
    ETADSFAINV PLPTRTGDAA YLLSFRTALS SVVQCFDPEA MVVQCGADTI 350
    AGDLIGRLCV TTLAHTQCVA DVLSLERPTV LLGGGGYHVF HTARCWAIHT 400
    ATALGRTAAQ LPLYIPRTDP YYMDYRRECT PKRPTLHVFL DPDVDDPLPL 450
    GDSLAFWRQL CRSIQWQMRA ARLVRQGFFR TLQLCRQRRA ALLRQFATQE 500
    AGRESGIGVS GPKRPRSANA TDRDAKEGVE DRVVSA 536
    Length:536
    Mass (Da):58,127
    Last modified:May 1, 2007 - v1
    Checksum:i28DEB24A4A029B71
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FR796456 Genomic DNA. Translation: CAM68400.1.
    RefSeqiXP_001465967.1. XM_001465930.1.

    Genome annotation databases

    GeneIDi5069396.
    KEGGilif:LINJ_24_1410.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FR796456 Genomic DNA. Translation: CAM68400.1 .
    RefSeqi XP_001465967.1. XM_001465930.1.

    3D structure databases

    ProteinModelPortali A4I0X6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5671.LinJ24.1050.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 5069396.
    KEGGi lif:LINJ_24_1410.

    Phylogenomic databases

    eggNOGi COG0123.
    KOi K06067.
    OMAi CHARPAT.

    Family and domain databases

    Gene3Di 3.40.800.20. 1 hit.
    InterProi IPR000286. His_deacetylse.
    IPR003084. His_deacetylse_1.
    IPR023801. His_deacetylse_dom.
    [Graphical view ]
    PANTHERi PTHR10625. PTHR10625. 1 hit.
    Pfami PF00850. Hist_deacetyl. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037913. His_deacetylse_1. 1 hit.
    PRINTSi PR01270. HDASUPER.
    PR01271. HISDACETLASE.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JPCM5Imported.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JPCM5Imported.

    Entry informationi

    Entry nameiA4I0X6_LEIIN
    AccessioniPrimary (citable) accession number: A4I0X6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 1, 2007
    Last sequence update: May 1, 2007
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3