ID   A4HYJ9_LEIIN            Unreviewed;      1165 AA.
AC   A4HYJ9; A0A2K4YSN2; A0A381MG09;
DT   01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2007, sequence version 1.
DT   27-MAR-2024, entry version 83.
DE   RecName: Full=BRCA2 OB1 domain-containing protein {ECO:0000259|Pfam:PF09103};
GN   ORFNames=LINJ_20_0070 {ECO:0000313|EMBL:CAM67384.1};
OS   Leishmania infantum.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX   NCBI_TaxID=5671 {ECO:0000313|EMBL:CAM67384.1, ECO:0000313|Proteomes:UP000008153};
RN   [1] {ECO:0000313|EMBL:CAM67384.1, ECO:0000313|Proteomes:UP000008153}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JPCM5 {ECO:0000313|EMBL:CAM67384.1,
RC   ECO:0000313|Proteomes:UP000008153};
RX   PubMed=17572675; DOI=10.1038/ng2053;
RA   Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA   Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA   Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA   Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA   Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA   Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA   Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA   Mottram J.C., Smith D.F., Berriman M.;
RT   "Comparative genomic analysis of three Leishmania species that cause
RT   diverse human disease.";
RL   Nat. Genet. 39:839-847(2007).
RN   [2] {ECO:0000313|EMBL:CAM67384.1, ECO:0000313|Proteomes:UP000008153}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JPCM5 {ECO:0000313|EMBL:CAM67384.1,
RC   ECO:0000313|Proteomes:UP000008153};
RX   PubMed=22038252; DOI=10.1101/gr.122945.111;
RA   Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA   Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA   Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA   Hertz-Fowler C., Mottram J.C.;
RT   "Chromosome and gene copy number variation allow major structural change
RT   between species and strains of Leishmania.";
RL   Genome Res. 21:2129-2142(2011).
RN   [3] {ECO:0007829|PDB:7QV8}
RP   X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) OF 108-140.
RX   PubMed=35502837; DOI=10.1042/bcj20220141;
RA   Pantelejevs T., Hyvonen M.;
RT   "Divergent binding mode for a protozoan BRC repeat to RAD51.";
RL   Biochem. J. 479:1031-1043(2022).
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DR   EMBL; FR796452; CAM67384.1; -; Genomic_DNA.
DR   RefSeq; XP_001465140.1; XM_001465103.1.
DR   PDB; 7QV8; X-ray; 2.15 A; D=108-140.
DR   AlphaFoldDB; A4HYJ9; -.
DR   SMR; A4HYJ9; -.
DR   STRING; 5671.A4HYJ9; -.
DR   GeneID; 5068552; -.
DR   KEGG; lif:LINJ_20_0070; -.
DR   VEuPathDB; TriTrypDB:LINF_200005600; -.
DR   eggNOG; KOG4751; Eukaryota.
DR   InParanoid; A4HYJ9; -.
DR   OMA; RRAWHPL; -.
DR   OrthoDB; 130625at2759; -.
DR   Proteomes; UP000008153; Chromosome 20.
DR   GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:InterPro.
DR   CDD; cd04493; BRCA2DBD_OB1; 1.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 2.
DR   InterPro; IPR015525; BRCA2.
DR   InterPro; IPR015187; BRCA2_OB_1.
DR   InterPro; IPR002093; BRCA2_repeat.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   PANTHER; PTHR11289:SF0; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN; 1.
DR   PANTHER; PTHR11289; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN BRCA2; 1.
DR   Pfam; PF09103; BRCA-2_OB1; 1.
DR   Pfam; PF00634; BRCA2; 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR   PROSITE; PS50138; BRCA2_REPEAT; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:7QV8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008153}.
FT   DOMAIN          424..535
FT                   /note="BRCA2 OB1"
FT                   /evidence="ECO:0000259|Pfam:PF09103"
SQ   SEQUENCE   1165 AA;  125061 MW;  F96A77CE08857976 CRC64;
     MKTIACPHCT FINPPSKVKC GVCLRLLRKR ERTVADASPA TANRGRKGTP SPSSTPTEHD
     SPATGSSQVR CDTTKSSMPL ATPKSGTVAS AQAVQPPDVE AMAAAPPLVP TLFSTASGKP
     VTVRRESLQK VAERLGDLAA PDMEARVPTL FETGRGKAVT VQKRSLDKAE ASMDSLEADG
     APSTSAPALS ATTGGAAVRV PAVPLQAPAE RLRLKSLSDK DDTSDTAAVR SIGAPRQTAR
     AEALSRGLTT STSECGLRAL ALHVIGGQRR GFVPPQQRPS AQPLAKLTHA VPLVKTSALT
     ILRFNPDACT CRSITPSPSL SSITSLMFSF KGSDCGKVLA ALLGVSGAES VQPLHWHAML
     LKLGASPKHC TINWCRHALV SAMARAHFMT KVPSGALPSA FSPVTVLLCV MQMYNAEMVN
     GERPALRKMV EGDISSASLV VLYMSSVSEE RSSPHMRIVT LSDGIYHLKV TCDVPLSNLI
     REGVLKPGQR MAVCGAKSLL HRQCAPTECE EQVVLSINYN CVRAVAQQTP LGVCHGEPLP
     LPLSLVHPLG GLVPAIEGVV ARTLPSFFVS EEATETPGTH DGARQARNRV FKTVRNAHAQ
     LQVSDRLRRE AEAWADGEAA QSKPLSRVTS LLIVKDNAEA LVQQWETVDE RVLLADDDGG
     ASLPVEGSWV TLYAVNPAKS RTAAAPFPRA KLFFSSRQLH YVPSKNPLQH LRRIWMAATD
     NKSTAGVGDV ADVCGLYMGS HRNEQGTFAL LLLRNDTYAL LQVPVPSAGR ALSLPLPATE
     RLSLVVLNAT FLTGEDPVAG SDCCRLFANE YTAVLQRSTQ ANLKEALETA AQLRGLVDAA
     PQKYAARKAE VFRCIDEGEP SGGLGLGSST ALTIRDGQGV PEVPLNVWRD APLASPSAAA
     TSLVPAQRYG RLPYYLRQDN ERAIAGKLTG VLLPSAALPT PAVPTAVQGP YSATTIHPGV
     REPLVQPANS VAGARSRHYG NIADLMFLFD PRLNRRAWHP LTDPLQVTSS EVVRHGECFK
     RAQLCWRLSA DSADDMTCRV EESSILGTVL ESVCPLQELC SVIADERHID VSLARSERLV
     QWRRQDSLSV WWRFFTDSRA LASPADLDGA SSEHLWWLPA EWTAAMRTVS AKLQAAFFYF
     SLSGEVLRHV RLISDCCSVA ELPCD
//