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A4HXU4

- CISY_LEIIN

UniProt

A4HXU4 - CISY_LEIIN

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Protein

Probable citrate synthase, mitochondrial

Gene
LinJ18.0690, LinJ_18_0690
Organism
Leishmania infantum
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei297 – 2971 By similarity
Active sitei351 – 3511 By similarity
Active sitei406 – 4061 By similarity

GO - Molecular functioni

  1. transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer Source: InterPro

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Tricarboxylic acid cycle

Enzyme and pathway databases

UniPathwayiUPA00223; UER00717.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable citrate synthase, mitochondrial (EC:2.3.3.16)
Gene namesi
ORF Names:LinJ18.0690, LinJ_18_0690
OrganismiLeishmania infantum
Taxonomic identifieri5671 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania
ProteomesiUP000008153: Chromosome 18

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 470Probable citrate synthase, mitochondrialPRO_0000291605
Transit peptidei1 – ?Mitochondrion Reviewed prediction

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi5671.LinJ18.0690.

Structurei

3D structure databases

ProteinModelPortaliA4HXU4.
SMRiA4HXU4. Positions 24-463.

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0372.
HOGENOMiHOG000130831.
KOiK01647.
OMAiELIYEDC.

Family and domain databases

Gene3Di1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A4HXU4-1 [UniParc]FASTAAdd to Basket

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MRALRCSIIR GVAGLRMASS VLDEMKEQML RRSKEDHKKI GDLRKKHGHE    50
KLCDATIDAV YGGMRGITGL VYEPSLLDSA EGIRFRGLTI LECQEMLPKA 100
PGGKEPLPEA MFWLLMTGEV PTEEQARGLN AELHRRVDPE AIAAAQKAIA 150
ALPKNAHPMT AFSVGVLALQ TYSKFAAAYA AGKSNKKTYW EYALEDSLDM 200
LARTPAVAAM IYNRETKGQV ELAAPSNSDL DWAANFAKML GFQDEEFREC 250
MRLYLSVHAD HEGGNVSAHT TTLVASALSD PYLAFSAGLN GLAGPLHGLA 300
NQEVLKYLFS MQERVKADGV NVHDEAALEK ALTKYTWELL NSGQVVPGYG 350
HAVLRKVDPR YTCQRNFCLR HNFQDDLFKL VNTIYMIMPG ILKEHGKTKN 400
PYPNVDAHSG VLLQHYGLTE QNYYTVLFGL SRQMGVLAGV VWDRLQGRPL 450
ERPKSITTEM LAKKYLCNSL 470
Length:470
Mass (Da):52,192
Last modified:May 1, 2007 - v1
Checksum:iD38F325BC1A97824
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FR796450 Genomic DNA. Translation: CAM67122.1.
RefSeqiXP_001464885.1. XM_001464848.1.

Genome annotation databases

GeneIDi5068291.
KEGGilif:LINJ_18_0690.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FR796450 Genomic DNA. Translation: CAM67122.1 .
RefSeqi XP_001464885.1. XM_001464848.1.

3D structure databases

ProteinModelPortali A4HXU4.
SMRi A4HXU4. Positions 24-463.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5671.LinJ18.0690.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5068291.
KEGGi lif:LINJ_18_0690.

Phylogenomic databases

eggNOGi COG0372.
HOGENOMi HOG000130831.
KOi K01647.
OMAi ELIYEDC.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER00717 .

Family and domain databases

Gene3Di 1.10.580.10. 1 hit.
InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
[Graphical view ]
PANTHERi PTHR11739. PTHR11739. 1 hit.
Pfami PF00285. Citrate_synt. 1 hit.
[Graphical view ]
PRINTSi PR00143. CITRTSNTHASE.
SUPFAMi SSF48256. SSF48256. 1 hit.
PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JPCM5.

Entry informationi

Entry nameiCISY_LEIIN
AccessioniPrimary (citable) accession number: A4HXU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: May 1, 2007
Last modified: June 11, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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