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A4HXU4 (CISY_LEIIN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable citrate synthase, mitochondrial

EC=2.3.3.16
Gene names
ORF Names:LinJ18.0690, LinJ_18_0690
OrganismLeishmania infantum [Reference proteome]
Taxonomic identifier5671 [NCBI]
Taxonomic lineageEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania

Protein attributes

Sequence length470 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.

Subunit structure

Homodimer By similarity.

Subcellular location

Mitochondrion matrix By similarity.

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Sequence similarities

Belongs to the citrate synthase family.

Ontologies

Keywords
   Biological processTricarboxylic acid cycle
   Cellular componentMitochondrion
   DomainTransit peptide
   Molecular functionTransferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcellular carbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

tricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentmitochondrial matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functiontransferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential
Chain? – 470Probable citrate synthase, mitochondrialPRO_0000291605

Sites

Active site2971 By similarity
Active site3511 By similarity
Active site4061 By similarity

Sequences

Sequence LengthMass (Da)Tools
A4HXU4 [UniParc].

Last modified May 1, 2007. Version 1.
Checksum: D38F325BC1A97824

FASTA47052,192
        10         20         30         40         50         60 
MRALRCSIIR GVAGLRMASS VLDEMKEQML RRSKEDHKKI GDLRKKHGHE KLCDATIDAV 

        70         80         90        100        110        120 
YGGMRGITGL VYEPSLLDSA EGIRFRGLTI LECQEMLPKA PGGKEPLPEA MFWLLMTGEV 

       130        140        150        160        170        180 
PTEEQARGLN AELHRRVDPE AIAAAQKAIA ALPKNAHPMT AFSVGVLALQ TYSKFAAAYA 

       190        200        210        220        230        240 
AGKSNKKTYW EYALEDSLDM LARTPAVAAM IYNRETKGQV ELAAPSNSDL DWAANFAKML 

       250        260        270        280        290        300 
GFQDEEFREC MRLYLSVHAD HEGGNVSAHT TTLVASALSD PYLAFSAGLN GLAGPLHGLA 

       310        320        330        340        350        360 
NQEVLKYLFS MQERVKADGV NVHDEAALEK ALTKYTWELL NSGQVVPGYG HAVLRKVDPR 

       370        380        390        400        410        420 
YTCQRNFCLR HNFQDDLFKL VNTIYMIMPG ILKEHGKTKN PYPNVDAHSG VLLQHYGLTE 

       430        440        450        460        470 
QNYYTVLFGL SRQMGVLAGV VWDRLQGRPL ERPKSITTEM LAKKYLCNSL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FR796450 Genomic DNA. Translation: CAM67122.1.
RefSeqXP_001464885.1. XM_001464848.1.

3D structure databases

ProteinModelPortalA4HXU4.
SMRA4HXU4. Positions 24-463.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5671.LinJ18.0690.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5068291.
KEGGlif:LINJ_18_0690.

Phylogenomic databases

eggNOGCOG0372.
HOGENOMHOG000130831.
KOK01647.
OMAELIYEDC.

Enzyme and pathway databases

UniPathwayUPA00223; UER00717.

Family and domain databases

Gene3D1.10.580.10. 1 hit.
InterProIPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
[Graphical view]
PANTHERPTHR11739. PTHR11739. 1 hit.
PfamPF00285. Citrate_synt. 1 hit.
[Graphical view]
PRINTSPR00143. CITRTSNTHASE.
SUPFAMSSF48256. SSF48256. 1 hit.
PROSITEPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCISY_LEIIN
AccessionPrimary (citable) accession number: A4HXU4
Entry history
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: May 1, 2007
Last modified: June 11, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways