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A4HXU4

- CISY_LEIIN

UniProt

A4HXU4 - CISY_LEIIN

Protein

Probable citrate synthase, mitochondrial

Gene

LinJ18.0690

Organism
Leishmania infantum
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (01 May 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei297 – 2971PROSITE-ProRule annotation
    Active sitei351 – 3511PROSITE-ProRule annotation
    Active sitei406 – 4061PROSITE-ProRule annotation

    GO - Molecular functioni

    1. transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer Source: InterPro

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Enzyme and pathway databases

    UniPathwayiUPA00223; UER00717.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable citrate synthase, mitochondrial (EC:2.3.3.16)
    Gene namesi
    ORF Names:LinJ18.0690, LinJ_18_0690
    OrganismiLeishmania infantum
    Taxonomic identifieri5671 [NCBI]
    Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania
    ProteomesiUP000008153: Chromosome 18

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 470Probable citrate synthase, mitochondrialPRO_0000291605
    Transit peptidei1 – ?MitochondrionSequence Analysis

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi5671.LinJ18.0690.

    Structurei

    3D structure databases

    ProteinModelPortaliA4HXU4.
    SMRiA4HXU4. Positions 24-463.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the citrate synthase family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0372.
    HOGENOMiHOG000130831.
    KOiK01647.
    OMAiELIYEDC.

    Family and domain databases

    Gene3Di1.10.580.10. 1 hit.
    InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
    IPR002020. Citrate_synthase-like.
    IPR016141. Citrate_synthase-like_core.
    IPR019810. Citrate_synthase_AS.
    [Graphical view]
    PANTHERiPTHR11739. PTHR11739. 1 hit.
    PfamiPF00285. Citrate_synt. 1 hit.
    [Graphical view]
    PRINTSiPR00143. CITRTSNTHASE.
    SUPFAMiSSF48256. SSF48256. 1 hit.
    PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A4HXU4-1 [UniParc]FASTAAdd to Basket

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    MRALRCSIIR GVAGLRMASS VLDEMKEQML RRSKEDHKKI GDLRKKHGHE    50
    KLCDATIDAV YGGMRGITGL VYEPSLLDSA EGIRFRGLTI LECQEMLPKA 100
    PGGKEPLPEA MFWLLMTGEV PTEEQARGLN AELHRRVDPE AIAAAQKAIA 150
    ALPKNAHPMT AFSVGVLALQ TYSKFAAAYA AGKSNKKTYW EYALEDSLDM 200
    LARTPAVAAM IYNRETKGQV ELAAPSNSDL DWAANFAKML GFQDEEFREC 250
    MRLYLSVHAD HEGGNVSAHT TTLVASALSD PYLAFSAGLN GLAGPLHGLA 300
    NQEVLKYLFS MQERVKADGV NVHDEAALEK ALTKYTWELL NSGQVVPGYG 350
    HAVLRKVDPR YTCQRNFCLR HNFQDDLFKL VNTIYMIMPG ILKEHGKTKN 400
    PYPNVDAHSG VLLQHYGLTE QNYYTVLFGL SRQMGVLAGV VWDRLQGRPL 450
    ERPKSITTEM LAKKYLCNSL 470
    Length:470
    Mass (Da):52,192
    Last modified:May 1, 2007 - v1
    Checksum:iD38F325BC1A97824
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FR796450 Genomic DNA. Translation: CAM67122.1.
    RefSeqiXP_001464885.1. XM_001464848.1.

    Genome annotation databases

    GeneIDi5068291.
    KEGGilif:LINJ_18_0690.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FR796450 Genomic DNA. Translation: CAM67122.1 .
    RefSeqi XP_001464885.1. XM_001464848.1.

    3D structure databases

    ProteinModelPortali A4HXU4.
    SMRi A4HXU4. Positions 24-463.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5671.LinJ18.0690.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 5068291.
    KEGGi lif:LINJ_18_0690.

    Phylogenomic databases

    eggNOGi COG0372.
    HOGENOMi HOG000130831.
    KOi K01647.
    OMAi ELIYEDC.

    Enzyme and pathway databases

    UniPathwayi UPA00223 ; UER00717 .

    Family and domain databases

    Gene3Di 1.10.580.10. 1 hit.
    InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
    IPR002020. Citrate_synthase-like.
    IPR016141. Citrate_synthase-like_core.
    IPR019810. Citrate_synthase_AS.
    [Graphical view ]
    PANTHERi PTHR11739. PTHR11739. 1 hit.
    Pfami PF00285. Citrate_synt. 1 hit.
    [Graphical view ]
    PRINTSi PR00143. CITRTSNTHASE.
    SUPFAMi SSF48256. SSF48256. 1 hit.
    PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JPCM5.

    Entry informationi

    Entry nameiCISY_LEIIN
    AccessioniPrimary (citable) accession number: A4HXU4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 26, 2007
    Last sequence update: May 1, 2007
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Miscellaneous

    Citrate synthase is found in nearly all cells capable of oxidative metabolism.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3