ID   A4HUV6_LEIIN            Unreviewed;       746 AA.
AC   A4HUV6; A0A2K4YNJ7; A0A381MEH8;
DT   01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2007, sequence version 1.
DT   27-MAR-2024, entry version 66.
DE   SubName: Full=Putative DNA ligase {ECO:0000313|EMBL:CAM66217.1};
DE            EC=6.5.1.1 {ECO:0000313|EMBL:CAM66217.1};
GN   ORFNames=LINJ_11_0450 {ECO:0000313|EMBL:CAM66217.1};
OS   Leishmania infantum.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX   NCBI_TaxID=5671 {ECO:0000313|EMBL:CAM66217.1, ECO:0000313|Proteomes:UP000008153};
RN   [1] {ECO:0000313|EMBL:CAM66217.1, ECO:0000313|Proteomes:UP000008153}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JPCM5 {ECO:0000313|EMBL:CAM66217.1,
RC   ECO:0000313|Proteomes:UP000008153};
RX   PubMed=17572675; DOI=10.1038/ng2053;
RA   Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA   Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA   Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA   Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA   Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA   Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA   Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA   Mottram J.C., Smith D.F., Berriman M.;
RT   "Comparative genomic analysis of three Leishmania species that cause
RT   diverse human disease.";
RL   Nat. Genet. 39:839-847(2007).
RN   [2] {ECO:0000313|EMBL:CAM66217.1, ECO:0000313|Proteomes:UP000008153}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JPCM5 {ECO:0000313|EMBL:CAM66217.1,
RC   ECO:0000313|Proteomes:UP000008153};
RX   PubMed=22038252; DOI=10.1101/gr.122945.111;
RA   Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA   Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA   Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA   Hertz-Fowler C., Mottram J.C.;
RT   "Chromosome and gene copy number variation allow major structural change
RT   between species and strains of Leishmania.";
RL   Genome Res. 21:2129-2142(2011).
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DR   EMBL; FR796443; CAM66217.1; -; Genomic_DNA.
DR   RefSeq; XP_001463847.1; XM_001463810.1.
DR   AlphaFoldDB; A4HUV6; -.
DR   GeneID; 5067223; -.
DR   KEGG; lif:LINJ_11_0450; -.
DR   VEuPathDB; TriTrypDB:LINF_110009400; -.
DR   eggNOG; ENOG502R16X; Eukaryota.
DR   InParanoid; A4HUV6; -.
DR   OMA; LFWIEEE; -.
DR   OrthoDB; 124958at2759; -.
DR   Proteomes; UP000008153; Chromosome 11.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   PANTHER; PTHR47810; DNA LIGASE; 1.
DR   PANTHER; PTHR47810:SF5; LIGASE, PUTATIVE-RELATED; 1.
DR   SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
PE   4: Predicted;
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   Ligase {ECO:0000313|EMBL:CAM66217.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008153}.
SQ   SEQUENCE   746 AA;  80693 MW;  067ECD83B4DEC1E8 CRC64;
     MALGTLDILE HRLQAAGLGG TTNTAATPKL GAAPSASRNY SEADKVDQLK WFSSSVDAPF
     FISPKHDGVR LISYVPPTTA TESPSAQQAS SKTKKTGATT AASPPLTTCY SRYGRPIYGL
     FWIEEELRLL RALCGDASLI IDGELYLHQT DMDASRAGQE GRDDAPDGTK RKPPRRALPS
     SDADGVNNFN TGFLAVSALV NRFRSSTFQC ASEEGVLKYV PSLPRLCVFD VPSYSPCANP
     LAPPTRDAPT AISAASRLHV VTKASVKDDE SSQQVLAELQ RVRSNVTDAL RLNDVEQLRI
     IPNVTPFSQR LRTMHYLFEL LSRGMESPVL RQHFCPTSAR MCSAPTTRSI RDCRKHTPMA
     AQVQPPHSGI GQYHGGHFVS RIPYQLVKSL EDTTQRVLPV YLDAGYEGAV IRAPVNTYDF
     KEKTKGTLAA LVAPLLRATE TTKTRRGRHL RGTNAGAGEA SGRRARNRAA LLLSLNAGPV
     LGAATPLMVH AYRGDAPRRE PMQPILPSDA GLTDAELDVL DVVAVGRRAI LQSAKLPQRS
     MTAVKVLTYH DREYPILRPL LKEPSKNPRT RELVSIPRSH VRALGYSIKP STGTALSDGD
     EATTLTPATS RCGKKETKSM NHATTSGEGS AVFYGLQCLA ENGLVFNVSL PKMTLAQQNT
     LLQHLLSAGR DAMRDGREAA SATMKTLHNR RSNAKAPYGG AAHASPSKIV SLAGLYATVK
     FSTLTEHGLP RFGSVKAIRG GKGWFM
//