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A4HSF7 (A4HSF7_LEIIN) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names
EC=1.8.1.12 EMBL CAM65344.1
Gene names
Name:TRYR EMBL CAM65344.1
ORF Names:LINJ_05_0350 EMBL CAM65344.1
OrganismLeishmania infantum [Reference proteome]
Taxonomic identifier5671 [NCBI]
Taxonomic lineageEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania

Protein attributes

Sequence length491 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding14 – 152FAD PDB 2X50 PDB 2JK6 PDB 2W0H PDB 4ADW PDB 2YAU PDB 4APN
Nucleotide binding34 – 352FAD PDB 2X50 PDB 2JK6 PDB 2W0H PDB 4ADW PDB 2YAU PDB 4APN
Nucleotide binding46 – 472FAD PDB 2X50 PDB 2JK6 PDB 2W0H PDB 4ADW PDB 2YAU PDB 4APN
Nucleotide binding196 – 2027NADP PDB 2X50 PDB 2W0H PDB 4ADW PDB 2YAU PDB 4APN
Nucleotide binding221 – 2222NADP PDB 2X50 PDB 2W0H PDB 4ADW PDB 2YAU PDB 4APN
Nucleotide binding284 – 2863NADP PDB 2X50 PDB 2W0H PDB 4ADW PDB 2YAU PDB 4APN
Nucleotide binding333 – 3353FAD PDB 2X50 PDB 2JK6 PDB 2W0H PDB 4ADW PDB 2YAU PDB 4APN
Region38 – 392Sulfate 1 binding PDB 2X50 PDB 2JK6 PDB 2W0H
Region221 – 2222Sulfate 3 binding
Region221 – 2222Sulfate 4 binding
Region284 – 2863Sulfate 2 binding
Region284 – 2863Sulfate 3 binding
Region462 – 4643Sulfate 2 binding PDB 2YAU

Sites

Binding site101FAD PDB 4ADW
Binding site511FAD PDB 2X50 PDB 2JK6 PDB 2W0H PDB 4ADW PDB 2YAU PDB 4APN
Binding site561FAD PDB 2X50 PDB 2JK6 PDB 4APN
Binding site601FAD PDB 2X50 PDB 2JK6 PDB 2W0H PDB 4ADW PDB 2YAU PDB 4APN
Binding site611Sulfate 2 PDB 2YAU
Binding site1271FAD; via amide nitrogen and carbonyl oxygen PDB 2X50 PDB 2JK6 PDB 2W0H PDB 4ADW PDB 2YAU PDB 4APN
Binding site1591FAD; via carbonyl oxygen PDB 4ADW PDB 2YAU
Binding site2281NADP PDB 2X50 PDB 2W0H PDB 4ADW PDB 4APN
Binding site2281Sulfate 3
Binding site2281Sulfate 4
Binding site3271FAD PDB 2X50 PDB 2JK6 PDB 2W0H PDB 4ADW PDB 2YAU PDB 4APN
Binding site3331NADP; via carbonyl oxygen PDB 2X50 PDB 2W0H PDB 2YAU PDB 4APN
Binding site3651NADP; via carbonyl oxygen PDB 2X50 PDB 2W0H PDB 4ADW PDB 2YAU PDB 4APN
Binding site3991Sulfate 2; via amide nitrogen PDB 2YAU
Binding site4611FAD; via carbonyl oxygen PDB 2JK6 PDB 2W0H PDB 2YAU PDB 4APN

Sequences

Sequence LengthMass (Da)Tools
A4HSF7 [UniParc].

Last modified May 1, 2007. Version 1.
Checksum: 1E41FDC657DDCF67

FASTA49153,026
        10         20         30         40         50         60 
MSRAYDLVVL GAGSGGLEAG WNAAVTHKKK VAVVDVQATH GPPLFAALGG TCVNVGCVPK 

        70         80         90        100        110        120 
KLMVTGAQYM DLIRESGGFG WEMDRESLCP NWKTLIAAKN KVVNSINESY KSMFADTEGL 

       130        140        150        160        170        180 
SFHMGFGALQ DAHTVVVRKS EDPHSDVLET LDTEYILIAT GSWPTRLGVP GDEFCITSNE 

       190        200        210        220        230        240 
AFYLEDAPKR MLCVGGGYIA VEFAGIFNGY KPCGGYVDLC YRGDLILRGF DTEVRKSLTK 

       250        260        270        280        290        300 
QLGANGIRVR TNLNPTKITK NEDGSNHVHF NDGTEEDYDQ VMLAIGRVPR SQALQLDKAG 

       310        320        330        340        350        360 
VRTGKNGAVQ VDAYSKTSVD NIYAIGDVTN RVMLTPVAIN EGAAFVETVF GGKPRATDHT 

       370        380        390        400        410        420 
KVACAVFSIP PIGTCGMTEE EAAKNYETVA VYASSFTPLM HNISGSKHKE FMIRIITNES 

       430        440        450        460        470        480 
NGEVLGVHML GDSAPEIIQS VGICMKMGAK ISDFHSTIGV HPTSAEELCS MRTPAYFYES 

       490 
GKRVEKLSSN L 

« Hide

References

« Hide 'large scale' references
[1]"Comparative genomic analysis of three Leishmania species that cause diverse human disease."
Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A., Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A., Fraser A., Rajandream M.-A., Carver T., Norbertczak H., Chillingworth T., Hance Z. expand/collapse author list , Jagels K., Moule S., Ormond D., Rutter S., Sqaures R., Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S., Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P., Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R.O., Barrell B., Cruz A.K., Mottram J.C., Smith D.F., Berriman M.
Nat. Genet. 39:839-847(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JPCM5 EMBL CAM65344.1.
[2]"Molecular basis of antimony treatment in leishmaniasis."
Baiocco P., Colotti G., Franceschini S., Ilari A.
J. Med. Chem. 52:2603-2612(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.95 ANGSTROMS) IN COMPLEX WITH FAD; NADP AND SULFATE.
[3]"A gold-containing drug against parasitic polyamine metabolism: the X-ray structure of trypanothione reductase from Leishmania infantum in complex with auranofin reveals a dual mechanism of enzyme inhibition."
Ilari A., Baiocco P., Messori L., Fiorillo A., Boffi A., Gramiccia M., Di Muccio T., Colotti G.
Amino Acids 42:803-811(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.50 ANGSTROMS) IN COMPLEX WITH FAD; NADP AND SULFATE.
[4]"Inhibition of Leishmania infantum trypanothione reductase by azole-based compounds: a comparative analysis with its physiological substrate by X-ray crystallography."
Baiocco P., Poce G., Alfonso S., Cocozza M., Porretta G.C., Colotti G., Biava M., Moraca F., Botta M., Yardley V., Fiorillo A., Lantella A., Malatesta F., Ilari A.
ChemMedChem 8:1175-1183(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.20 ANGSTROMS) IN COMPLEX WITH FAD AND NADP.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FR796437 Genomic DNA. Translation: CAM65344.1.
RefSeqXP_001462998.1. XM_001462961.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2JK6X-ray2.95A/B1-491[»]
2W0HX-ray3.00A/B1-491[»]
2X50X-ray3.30A/B1-490[»]
2YAUX-ray3.50A/B1-491[»]
4ADWX-ray3.61A/B1-491[»]
4APNX-ray3.20A/B1-491[»]
ProteinModelPortalA4HSF7.
SMRA4HSF7. Positions 2-486.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5671.LinJ05.0350.

Chemistry

ChEMBLCHEMBL1944501.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5066544.
KEGGlif:LINJ_05_0350.

Phylogenomic databases

eggNOGCOG1249.
KOK04283.
OMAVANHEAK.
ProtClustDBCLSZ2436777.

Family and domain databases

Gene3D3.30.390.30. 1 hit.
InterProIPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
IPR012999. Pyr_OxRdtase_I_AS.
IPR001327. Pyr_OxRdtase_NAD-bd_dom.
IPR001864. Trypnth_redctse.
[Graphical view]
PfamPF00070. Pyr_redox. 1 hit.
PF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
PRINTSPR00368. FADPNR.
PR00470. TRYPANRDTASE.
SUPFAMSSF55424. SSF55424. 1 hit.
TIGRFAMsTIGR01423. trypano_reduc. 1 hit.
PROSITEPS00076. PYRIDINE_REDOX_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceA4HSF7.

Entry information

Entry nameA4HSF7_LEIIN
AccessionPrimary (citable) accession number: A4HSF7
Entry history
Integrated into UniProtKB/TrEMBL: May 1, 2007
Last sequence update: May 1, 2007
Last modified: February 19, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)