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Protein
Submitted name:

Trypanothione reductase

Gene

TRYR

Organism
Leishmania infantum
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei56FADCombined sources1
Binding sitei60FADCombined sources1
Binding sitei127FAD; via amide nitrogen and carbonyl oxygenCombined sources1
Binding sitei159FAD; via carbonyl oxygenCombined sources1
Binding sitei198FADCombined sources1
Binding sitei228NADPCombined sources1
Binding sitei254NADPCombined sources1
Binding sitei333NADP; via carbonyl oxygenCombined sources1
Binding sitei365NADP; via carbonyl oxygenCombined sources1
Binding sitei461FAD; via carbonyl oxygenCombined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 15FADCombined sources6
Nucleotide bindingi34 – 35FADCombined sources2
Nucleotide bindingi46 – 47FADCombined sources2
Nucleotide bindingi51 – 52FADCombined sources2
Nucleotide bindingi196 – 202NADPCombined sources7
Nucleotide bindingi221 – 222NADPCombined sources2
Nucleotide bindingi284 – 286NADPCombined sources3
Nucleotide bindingi325 – 327FADCombined sources3
Nucleotide bindingi333 – 335FADCombined sources3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
LigandFADUniRule annotationCombined sources, Flavoprotein, NADPCombined sources, Nucleotide-bindingCombined sources

Enzyme and pathway databases

BRENDAi1.8.1.12 2949

Names & Taxonomyi

Protein namesi
Submitted name:
Trypanothione reductaseImported (EC:1.8.1.12Imported)
Gene namesi
Name:TRYRImported
ORF Names:LINJ_05_0350Imported
OrganismiLeishmania infantumImported
Taxonomic identifieri5671 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania
Proteomesi
  • UP000008153 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiTriTrypDB:LinJ.05.0350

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1944501

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi52 ↔ 57Combined sources
Disulfide bondi89 ↔ 213Combined sources

Interactioni

Protein-protein interaction databases

STRINGi435258.XP_001462998.1

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JK6X-ray2.95A/B1-491[»]
2W0HX-ray3.00A/B1-491[»]
2X50X-ray3.30A/B1-490[»]
2YAUX-ray3.50A/B1-491[»]
4ADWX-ray3.61A/B1-491[»]
4APNX-ray3.20A/B1-491[»]
5EBKX-ray3.51A/B1-491[»]
ProteinModelPortaliA4HSF7
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiA4HSF7

Family & Domainsi

Sequence similaritiesi

Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.UniRule annotation

Keywords - Domaini

Redox-active centerUniRule annotation

Phylogenomic databases

eggNOGiKOG0405 Eukaryota
COG1249 LUCA
InParanoidiA4HSF7
KOiK04283
OMAiVYGLHYL

Family and domain databases

Gene3Di3.30.390.30, 1 hit
3.50.50.60, 3 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR016156 FAD/NAD-linked_Rdtase_dimer_sf
IPR001100 Pyr_nuc-diS_OxRdtase
IPR004099 Pyr_nucl-diS_OxRdtase_dimer
IPR012999 Pyr_OxRdtase_I_AS
IPR001864 Trypnth_redctse
PfamiView protein in Pfam
PF07992 Pyr_redox_2, 1 hit
PF02852 Pyr_redox_dim, 1 hit
PIRSFiPIRSF000350 Mercury_reductase_MerA, 1 hit
PRINTSiPR00470 TRYPANRDTASE
SUPFAMiSSF51905 SSF51905, 2 hits
SSF55424 SSF55424, 1 hit
TIGRFAMsiTIGR01423 trypano_reduc, 1 hit
PROSITEiView protein in PROSITE
PS00076 PYRIDINE_REDOX_1, 1 hit

Sequencei

Sequence statusi: Complete.

A4HSF7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRAYDLVVL GAGSGGLEAG WNAAVTHKKK VAVVDVQATH GPPLFAALGG
60 70 80 90 100
TCVNVGCVPK KLMVTGAQYM DLIRESGGFG WEMDRESLCP NWKTLIAAKN
110 120 130 140 150
KVVNSINESY KSMFADTEGL SFHMGFGALQ DAHTVVVRKS EDPHSDVLET
160 170 180 190 200
LDTEYILIAT GSWPTRLGVP GDEFCITSNE AFYLEDAPKR MLCVGGGYIA
210 220 230 240 250
VEFAGIFNGY KPCGGYVDLC YRGDLILRGF DTEVRKSLTK QLGANGIRVR
260 270 280 290 300
TNLNPTKITK NEDGSNHVHF NDGTEEDYDQ VMLAIGRVPR SQALQLDKAG
310 320 330 340 350
VRTGKNGAVQ VDAYSKTSVD NIYAIGDVTN RVMLTPVAIN EGAAFVETVF
360 370 380 390 400
GGKPRATDHT KVACAVFSIP PIGTCGMTEE EAAKNYETVA VYASSFTPLM
410 420 430 440 450
HNISGSKHKE FMIRIITNES NGEVLGVHML GDSAPEIIQS VGICMKMGAK
460 470 480 490
ISDFHSTIGV HPTSAEELCS MRTPAYFYES GKRVEKLSSN L
Length:491
Mass (Da):53,026
Last modified:May 1, 2007 - v1
Checksum:i1E41FDC657DDCF67
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR796437 Genomic DNA Translation: CAM65344.1
RefSeqiXP_001462998.1, XM_001462961.1

Genome annotation databases

EnsemblProtistsiCAM65344; CAM65344; LINJ_05_0350
GeneDBiLinJ.05.0350:pep
GeneIDi5066544
KEGGilif:LINJ_05_0350

Similar proteinsi

Entry informationi

Entry nameiA4HSF7_LEIIN
AccessioniPrimary (citable) accession number: A4HSF7
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2007
Last sequence update: May 1, 2007
Last modified: April 25, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health