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Protein
Submitted name:

Trypanothione reductase

Gene

TRYR

Organism
Leishmania infantum
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei10FADCombined sources1
Binding sitei51FADCombined sources1
Binding sitei56FADCombined sources1
Binding sitei60FADCombined sources1
Binding sitei127FAD; via amide nitrogen and carbonyl oxygenCombined sources1
Binding sitei159FAD; via carbonyl oxygenCombined sources1
Binding sitei228NADPCombined sources1
Binding sitei327FADCombined sources1
Binding sitei333NADP; via carbonyl oxygenCombined sources1
Binding sitei365NADP; via carbonyl oxygenCombined sources1
Binding sitei461FAD; via carbonyl oxygenCombined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi14 – 15FADCombined sources2
Nucleotide bindingi34 – 35FADCombined sources2
Nucleotide bindingi46 – 47FADCombined sources2
Nucleotide bindingi196 – 202NADPCombined sources7
Nucleotide bindingi221 – 222NADPCombined sources2
Nucleotide bindingi284 – 286NADPCombined sources3
Nucleotide bindingi333 – 335FADCombined sources3

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Ligandi

FADUniRule annotationCombined sources, Flavoprotein, NADPCombined sources, Nucleotide-bindingCombined sources

Enzyme and pathway databases

BRENDAi1.8.1.12. 2949.

Names & Taxonomyi

Protein namesi
Submitted name:
Trypanothione reductaseImported (EC:1.8.1.12Imported)
Gene namesi
Name:TRYRImported
ORF Names:LINJ_05_0350Imported
OrganismiLeishmania infantumImported
Taxonomic identifieri5671 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania
Proteomesi
  • UP000008153 Componenti: Chromosome 5

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1944501.

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi52 ↔ 57Combined sources
Disulfide bondi89 ↔ 213Combined sources

Interactioni

Protein-protein interaction databases

STRINGi435258.XP_001462998.1.

Chemistry databases

BindingDBiA4HSF7.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JK6X-ray2.95A/B1-491[»]
2W0HX-ray3.00A/B1-491[»]
2X50X-ray3.30A/B1-490[»]
2YAUX-ray3.50A/B1-491[»]
4ADWX-ray3.61A/B1-491[»]
4APNX-ray3.20A/B1-491[»]
ProteinModelPortaliA4HSF7.
SMRiA4HSF7.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiA4HSF7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 342FAD/NAD-binding_domInterPro annotationAdd BLAST338
Domaini363 – 468Pyr_redox_dimInterPro annotationAdd BLAST106

Sequence similaritiesi

Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.UniRule annotation

Keywords - Domaini

Redox-active centerUniRule annotation

Phylogenomic databases

eggNOGiKOG0405. Eukaryota.
COG1249. LUCA.
InParanoidiA4HSF7.
KOiK04283.
OMAiTSAPIDY.

Family and domain databases

Gene3Di3.30.390.30. 1 hit.
3.50.50.60. 3 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR012999. Pyr_OxRdtase_I_AS.
IPR001864. Trypnth_redctse.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
PRINTSiPR00470. TRYPANRDTASE.
SUPFAMiSSF51905. SSF51905. 2 hits.
SSF55424. SSF55424. 1 hit.
TIGRFAMsiTIGR01423. trypano_reduc. 1 hit.
PROSITEiPS00076. PYRIDINE_REDOX_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4HSF7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRAYDLVVL GAGSGGLEAG WNAAVTHKKK VAVVDVQATH GPPLFAALGG
60 70 80 90 100
TCVNVGCVPK KLMVTGAQYM DLIRESGGFG WEMDRESLCP NWKTLIAAKN
110 120 130 140 150
KVVNSINESY KSMFADTEGL SFHMGFGALQ DAHTVVVRKS EDPHSDVLET
160 170 180 190 200
LDTEYILIAT GSWPTRLGVP GDEFCITSNE AFYLEDAPKR MLCVGGGYIA
210 220 230 240 250
VEFAGIFNGY KPCGGYVDLC YRGDLILRGF DTEVRKSLTK QLGANGIRVR
260 270 280 290 300
TNLNPTKITK NEDGSNHVHF NDGTEEDYDQ VMLAIGRVPR SQALQLDKAG
310 320 330 340 350
VRTGKNGAVQ VDAYSKTSVD NIYAIGDVTN RVMLTPVAIN EGAAFVETVF
360 370 380 390 400
GGKPRATDHT KVACAVFSIP PIGTCGMTEE EAAKNYETVA VYASSFTPLM
410 420 430 440 450
HNISGSKHKE FMIRIITNES NGEVLGVHML GDSAPEIIQS VGICMKMGAK
460 470 480 490
ISDFHSTIGV HPTSAEELCS MRTPAYFYES GKRVEKLSSN L
Length:491
Mass (Da):53,026
Last modified:May 1, 2007 - v1
Checksum:i1E41FDC657DDCF67
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR796437 Genomic DNA. Translation: CAM65344.1.
RefSeqiXP_001462998.1. XM_001462961.1.

Genome annotation databases

EnsemblProtistsiCAM65344; CAM65344; LINJ_05_0350.
GeneIDi5066544.
KEGGilif:LINJ_05_0350.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR796437 Genomic DNA. Translation: CAM65344.1.
RefSeqiXP_001462998.1. XM_001462961.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JK6X-ray2.95A/B1-491[»]
2W0HX-ray3.00A/B1-491[»]
2X50X-ray3.30A/B1-490[»]
2YAUX-ray3.50A/B1-491[»]
4ADWX-ray3.61A/B1-491[»]
4APNX-ray3.20A/B1-491[»]
ProteinModelPortaliA4HSF7.
SMRiA4HSF7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi435258.XP_001462998.1.

Chemistry databases

BindingDBiA4HSF7.
ChEMBLiCHEMBL1944501.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiCAM65344; CAM65344; LINJ_05_0350.
GeneIDi5066544.
KEGGilif:LINJ_05_0350.

Phylogenomic databases

eggNOGiKOG0405. Eukaryota.
COG1249. LUCA.
InParanoidiA4HSF7.
KOiK04283.
OMAiTSAPIDY.

Enzyme and pathway databases

BRENDAi1.8.1.12. 2949.

Miscellaneous databases

EvolutionaryTraceiA4HSF7.

Family and domain databases

Gene3Di3.30.390.30. 1 hit.
3.50.50.60. 3 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR012999. Pyr_OxRdtase_I_AS.
IPR001864. Trypnth_redctse.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
PRINTSiPR00470. TRYPANRDTASE.
SUPFAMiSSF51905. SSF51905. 2 hits.
SSF55424. SSF55424. 1 hit.
TIGRFAMsiTIGR01423. trypano_reduc. 1 hit.
PROSITEiPS00076. PYRIDINE_REDOX_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA4HSF7_LEIIN
AccessioniPrimary (citable) accession number: A4HSF7
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2007
Last sequence update: May 1, 2007
Last modified: November 2, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.