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Protein

Adenylosuccinate lyase

Gene

LINJ_04_0440

Organism
Leishmania infantum
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
N(6)-(1,2-dicarboxyethyl)AMP = fumarate + AMP.UniRule annotation

Pathwayi: AMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes AMP from IMP.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Adenylosuccinate synthetase (LinJ13.1120)
  2. Adenylosuccinate lyase (LINJ_04_0440)
This subpathway is part of the pathway AMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes AMP from IMP, the pathway AMP biosynthesis via de novo pathway and in Purine metabolism.

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Adenylosuccinate lyase (LINJ_04_0440)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationImported

Keywords - Biological processi

Purine biosynthesisUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00074; UER00132.
UPA00075; UER00336.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylosuccinate lyaseUniRule annotation (EC:4.3.2.2UniRule annotation)
Short name:
ASLUniRule annotation
Alternative name(s):
AdenylosuccinaseUniRule annotation
Gene namesi
ORF Names:LINJ_04_0440Imported
OrganismiLeishmania infantumImported
Taxonomic identifieri5671 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania
Proteomesi
  • UP000008153 Componenti: Chromosome 4

Interactioni

Protein-protein interaction databases

STRINGi435258.XP_001462882.1.

Structurei

3D structure databases

ProteinModelPortaliA4HS40.
SMRiA4HS40.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 338Lyase_1InterPro annotationAdd BLAST300
Domaini357 – 473ASL_CInterPro annotationAdd BLAST117

Sequence similaritiesi

Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG2700. Eukaryota.
COG0015. LUCA.
InParanoidiA4HS40.
KOiK01756.
OMAiTQVNPCD.

Family and domain databases

Gene3Di1.10.275.10. 1 hit.
InterProiIPR024083. Fumarase/histidase_N.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
IPR004769. Pur_lyase.
IPR013539. PurB_C.
[Graphical view]
PANTHERiPTHR11444. PTHR11444. 1 hit.
PfamiPF08328. ASL_C. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSiPR00149. FUMRATELYASE.
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00928. purB. 1 hit.
PROSITEiPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4HS40-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLPSAEEAA APAVTTTAHK APAEISQDSP LYSLSPLDGR YKRDTTPLRA
60 70 80 90 100
YFSEYALFKY RVQVEVLYFE ALCKEVPAIT QLRGVTDAQL GELRATTFEN
110 120 130 140 150
FAVDDAKIIK GIEAVTNHDI KAVEYYLKDK MSACGLEAEK EFIHFGLTSQ
160 170 180 190 200
DINNTSIPML LRDALHHHYI PTLDQLIALL KSKLPEWDVP MLARTHGQPA
210 220 230 240 250
SPTNLAKEFM VWIERLEEQR TMLLSIPNTG KFGGATGNFN AHLCAYPGVN
260 270 280 290 300
WLDFGELFLS KYLGLRRQRY TTQIEHYDNL AAICDACARL HTILMDLAKD
310 320 330 340 350
VWQYISLGYF DQKVRAGEVG SSAMPHKVNP IDFENAEGNL GMSNAVLGFL
360 370 380 390 400
SAKLPISRLQ RDLTDSTVLR NLGVPLSHAL IAFASLRRGI DKLLLNKDVI
410 420 430 440 450
ASDLEGNWAV VAEGIQTVLR REGYPKPYEA LKDLTRGNAH VTEETVHRFV
460 470
QQLEGITEEV RQELLAITPF TYVGYTAHP
Length:479
Mass (Da):53,552
Last modified:May 1, 2007 - v1
Checksum:iF5AAAF36C2E5E4FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR796436 Genomic DNA. Translation: CAM65068.1.
RefSeqiXP_001462882.1. XM_001462845.1.

Genome annotation databases

EnsemblProtistsiCAM65068; CAM65068; LINJ_04_0440.
GeneIDi5066328.
KEGGilif:LINJ_04_0440.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR796436 Genomic DNA. Translation: CAM65068.1.
RefSeqiXP_001462882.1. XM_001462845.1.

3D structure databases

ProteinModelPortaliA4HS40.
SMRiA4HS40.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi435258.XP_001462882.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiCAM65068; CAM65068; LINJ_04_0440.
GeneIDi5066328.
KEGGilif:LINJ_04_0440.

Phylogenomic databases

eggNOGiKOG2700. Eukaryota.
COG0015. LUCA.
InParanoidiA4HS40.
KOiK01756.
OMAiTQVNPCD.

Enzyme and pathway databases

UniPathwayiUPA00074; UER00132.
UPA00075; UER00336.

Family and domain databases

Gene3Di1.10.275.10. 1 hit.
InterProiIPR024083. Fumarase/histidase_N.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
IPR004769. Pur_lyase.
IPR013539. PurB_C.
[Graphical view]
PANTHERiPTHR11444. PTHR11444. 1 hit.
PfamiPF08328. ASL_C. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSiPR00149. FUMRATELYASE.
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00928. purB. 1 hit.
PROSITEiPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA4HS40_LEIIN
AccessioniPrimary (citable) accession number: A4HS40
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2007
Last sequence update: May 1, 2007
Last modified: November 2, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.