A4HQF9 (A4HQF9_LEIBR) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Methylenetetrahydrofolate reductase RuleBase RU003862
EC=1.5.1.20 RuleBase RU003862

Gene names

ORF Names:

LBRM_35_6720 EMBL CAM44425.1

Organism

Leishmania braziliensis

Taxonomic identifier

5660 [NCBI]

Taxonomic lineage

Eukaryota › Euglenozoa › Kinetoplastida › Trypanosomatidae › Leishmania › Leishmania braziliensis species complex

Protein attributes

Sequence length	309 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H. RuleBase RU003862
Cofactor	FAD By similarity. RuleBase RU003862
Sequence similarities	Belongs to the methylenetetrahydrofolate reductase family. RuleBase RU003862

Ontologies

Keywords
Ligand	FAD RuleBase RU003862 Flavoprotein RuleBase RU003862
Molecular function	Oxidoreductase RuleBase RU003862
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	methionine metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	methylenetetrahydrofolate reductase (NADPH) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A4HQF9 [UniParc]. Last modified May 1, 2007. Version 1. Checksum: FF98D56A92D9D127	FASTA	309	35,056
	10 20 30 40 50 60 MSGLISDAIA AEDANKWYTS YEFYPPRSEK AEENFMKVQI PNFMRQSPVF LDLTWGAGGR 70 80 90 100 110 120 TSETTMRLCK DLQNAYPDTP INMHITCTNM SHDLIKETLD FAKEHGIRNI LALRGDPPRG 130 140 150 160 170 180 DEFQSNPEGF TCARDLVRYI HATYGDYFCV SVAGYPEGHP SRIAEDGTIL DEDHQKELEY 190 200 210 220 230 240 LKEKVDAGAS VVITQLFYDA SLYVKFVKDC REMGITVPII AGLLPITTYA GFTRMVSLCK 250 260 270 280 290 300 TRVPGDVKKR VEELKENPEA LKEYGVEQCV QMIERIRASG LDYHHLHFYT LNSSAQTFQV LKRLNALVE

References

[1]

"Comparative genomic analysis of three Leishmania species that cause diverse human disease." Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A., Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A., Fraser A., Rajandream M.-A., Carver T., Norbertczak H., Chillingworth T., Hance Z. , Jagels K., Moule S., Ormond D., Rutter S., Sqaures R., Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S., Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P., Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R.O., Barrell B., Cruz A.K., Mottram J.C., Smith D.F., Berriman M. Nat. Genet. 39:839-847(2007) [PubMed: 17572675] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MHOM/BR/75/M2904.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FR799010 Genomic DNA. Translation: CAM44425.1.
RefSeq	XP_001569284.1. XM_001569234.1.
3D structure databases
ProteinModelPortal	A4HQF9.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5420268.
KEGG	lbz:LbrM35_V2.6720.
Organism-specific databases
EuPathDB	EupathDB:LbrM.35.6720.
Phylogenomic databases
HOGENOM	HBG649727.
OMA	ITQMFFD.
PhylomeDB	A4HQF9.
ProtClustDB	CLSZ2430716.
Family and domain databases
InterPro	IPR004621. Fadh2_euk. IPR003171. Mehydrof_redctse. [Graphical view]
KO	K00297.
Pfam	PF02219. MTHFR. 1 hit. [Graphical view]
TIGRFAMs	TIGR00677. Fadh2_euk. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A4HQF9_LEIBR

Accession

Primary (citable) accession number: A4HQF9

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2007
Last sequence update:	May 1, 2007
Last modified:	November 16, 2011
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)