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A4HN01 (A4HN01_LEIBR) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
6-phosphogluconate dehydrogenase, decarboxylating RuleBase RU000485 PIRNR PIRNR000109
EC=1.1.1.44 RuleBase RU000485 PIRNR PIRNR000109
Gene names
Name:6pgd EMBL ABY50510.1
Synonyms:6PGD EMBL ABV69576.1
ORF Names:LBRM_34_3250 EMBL CAM43542.1
OrganismLeishmania braziliensis
Taxonomic identifier5660 [NCBI]
Taxonomic lineageEukaryota › Euglenozoa › Kinetoplastida › Trypanosomatidae › Leishmania › Leishmania braziliensis species complex

Protein attributes

Sequence length479 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity. PIRNR PIRNR000109

Catalytic activity

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH. RuleBase RU000485 PIRNR PIRNR000109

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3. RuleBase RU004281 PIRNR PIRNR000109

Subunit structure

Homodimer By similarity. PIRNR PIRNR000109

Sequence similarities

Belongs to the 6-phosphogluconate dehydrogenase family. RuleBase RU000485 PIRNR PIRNR000109

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding9 – 146NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding32 – 343NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding77 – 793NADP By similarity PIRSR PIRSR000109-3
Region131 – 1333Substrate binding By similarity PIRSR PIRSR000109-2
Region189 – 1902Substrate binding By similarity PIRSR PIRSR000109-2

Sites

Active site1861Proton acceptor By similarity PIRSR PIRSR000109-1
Active site1931Proton donor By similarity PIRSR PIRSR000109-1
Binding site1051NADP By similarity PIRSR PIRSR000109-3
Binding site1051Substrate By similarity PIRSR PIRSR000109-2
Binding site1941Substrate By similarity PIRSR PIRSR000109-2
Binding site2631Substrate; via amide nitrogen By similarity PIRSR PIRSR000109-2
Binding site2901Substrate By similarity PIRSR PIRSR000109-2
Binding site4541Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2
Binding site4601Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2

Sequences

Sequence LengthMass (Da)Tools
A4HN01 [UniParc].

Last modified May 1, 2007. Version 1.
Checksum: B109231A539C48EA

FASTA47952,372
        10         20         30         40         50         60 
MSNDLGIIGL GVMGANLALN IAEKHFKVAV YNRTCSKTHD FLKEHEHETF ASNLQGYETM 

        70         80         90        100        110        120 
KEFAASLKKP RRAFILVQAG AATDSTIEQL KVVFENGDII IDTGNANFKD QSRRAAQLES 

       130        140        150        160        170        180 
QGLRFLGMGI SGGEEGARKG PAFFPGGTPS VWEEVRPIVE AASAKAEDGR PCVTFNGKGG 

       190        200        210        220        230        240 
AGSCVKMYHN AGEYAILQIW GEAYSALQAL GFNNDQVADV FESWKAGGFL KSYMLDISIA 

       250        260        270        280        290        300 
ACRAKEPAGN YLSEKVKDCI GSKGTGLWSA QEALEVGVPA PSLNMAVISR QMTMCKDERA 

       310        320        330        340        350        360 
ENFKAFPTFP CSVREQVKDK SPNAPEVKQL YHAVSLSIIA SYAQMFQCLR ELDKVHGFGL 

       370        380        390        400        410        420 
NLPATIATFR AGCILQGYLL IPMTKAFEEN PNLPNLMDAF TKEMKEGLPA YRQIVAMLTA 

       430        440        450        460        470 
STAVSLPVMT ASLAYINAMY TLILPYGQLV SLQRDVFGRH GYERVDKEGR ESFTWPAMQ

« Hide

References

« Hide 'large scale' references
[1]"Typing of four genetic loci discriminates among closely related species of New World Leishmania."
Tsukayama P., Lucas C., Bacon D.J.
Int. J. Parasitol. 39:355-362(2009) [PubMed: 18817779] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: MHOM/BR/84/LTB300 EMBL ABV69576.1.
[2]"Comparative genomic analysis of three Leishmania species that cause diverse human disease."
Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A., Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A., Fraser A., Rajandream M.-A., Carver T., Norbertczak H., Chillingworth T., Hance Z. expand/collapse author list , Jagels K., Moule S., Ormond D., Rutter S., Sqaures R., Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S., Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P., Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R.O., Barrell B., Cruz A.K., Mottram J.C., Smith D.F., Berriman M.
Nat. Genet. 39:839-847(2007) [PubMed: 17572675] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MHOM/BR/75/M2904.
[3]"Genetic evidence of sexual recombination in new world Leishmania populations from the sequence analysis of three isoenzyme markers."
Tsukayama P., Bacon D.J.
Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: MHOM/PE/91/LEH0375 EMBL ABY50512.1, MHOM/PE/93/LEH0022 EMBL ABY50510.1 and MHOM/PE/93/LEH1642 EMBL ABY50513.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		EU153344 Genomic DNA. Translation: ABV69576.1.
EU327919 Genomic DNA. Translation: ABY50510.1.
EU327921 Genomic DNA. Translation: ABY50512.1.
EU327922 Genomic DNA. Translation: ABY50513.1.
FR799009 Genomic DNA. Translation: CAM43542.1.
RefSeqXP_001568431.1. XM_001568381.1.

3D structure databases

ProteinModelPortalA4HN01.
SMRA4HN01. Positions 15-479.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5419385.
KEGGlbz:LbrM34_V2.3250.

Organism-specific databases

EuPathDBEupathDB:LbrM.34.3250.

Phylogenomic databases

HOGENOMHBG286913.
OMASNYPDTN.
PhylomeDBA4HN01.
ProtClustDBCLSZ2439211.

Family and domain databases

InterProIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:1.20.5.320. Fibritin/6PGD_C-extension. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00033.
PfamPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFPIRSF000109. 6PGD. 1 hit.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR00873. Gnd. 1 hit.
PROSITEPS00461. 6PGD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA4HN01_LEIBR
AccessionPrimary (citable) accession number: A4HN01
Entry history
Integrated into UniProtKB/TrEMBL: May 1, 2007
Last sequence update: May 1, 2007
Last modified: December 14, 2011
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info