ID A4HLC1_LEIBR Unreviewed; 187 AA. AC A4HLC1; DT 01-MAY-2007, integrated into UniProtKB/TrEMBL. DT 01-MAY-2007, sequence version 1. DT 27-MAR-2024, entry version 94. DE RecName: Full=V-type proton ATPase proteolipid subunit {ECO:0000256|RuleBase:RU363060}; GN ORFNames=LBRM_33_0850 {ECO:0000313|EMBL:CAM40615.1}, LBRM_33_0860 GN {ECO:0000313|EMBL:CAM40616.1}; OS Leishmania braziliensis. OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina; OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania; OC Leishmania braziliensis species complex. OX NCBI_TaxID=5660 {ECO:0000313|EMBL:CAM40615.1, ECO:0000313|Proteomes:UP000007258}; RN [1] {ECO:0000313|EMBL:CAM40615.1, ECO:0000313|Proteomes:UP000007258} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM40615.1, RC ECO:0000313|Proteomes:UP000007258}; RX PubMed=17572675; DOI=10.1038/ng2053; RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A., RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A., RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T., RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R., RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S., RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P., RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K., RA Mottram J.C., Smith D.F., Berriman M.; RT "Comparative genomic analysis of three Leishmania species that cause RT diverse human disease."; RL Nat. Genet. 39:839-847(2007). RN [2] {ECO:0000313|EMBL:CAM40615.1, ECO:0000313|Proteomes:UP000007258} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM40615.1, RC ECO:0000313|Proteomes:UP000007258}; RX PubMed=22038252; DOI=10.1101/gr.122945.111; RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A., RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D., RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F., RA Hertz-Fowler C., Mottram J.C.; RT "Chromosome and gene copy number variation allow major structural change RT between species and strains of Leishmania."; RL Genome Res. 21:2129-2142(2011). RN [3] {ECO:0000313|EMBL:CAM40615.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM40615.1}; RA Aslett M.; RL Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Vacuole membrane CC {ECO:0000256|RuleBase:RU363060}; Multi-pass membrane protein CC {ECO:0000256|RuleBase:RU363060}. CC -!- SIMILARITY: Belongs to the V-ATPase proteolipid subunit family. CC {ECO:0000256|ARBA:ARBA00007296, ECO:0000256|RuleBase:RU363060}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; FR799008; CAM40615.1; -; Genomic_DNA. DR EMBL; FR799008; CAM40616.1; -; Genomic_DNA. DR RefSeq; XP_001567855.1; XM_001567805.1. DR RefSeq; XP_001567856.1; XM_001567806.1. DR AlphaFoldDB; A4HLC1; -. DR STRING; 5660.A4HLC1; -. DR GeneID; 5418788; -. DR GeneID; 5418789; -. DR KEGG; lbz:LBRM_33_0850; -. DR KEGG; lbz:LBRM_33_0860; -. DR VEuPathDB; TriTrypDB:LbrM.33.0860; -. DR VEuPathDB; TriTrypDB:LBRM2903_210026700; -. DR InParanoid; A4HLC1; -. DR OMA; MSVCPPY; -. DR Proteomes; UP000007258; Chromosome 33. DR GO; GO:0033179; C:proton-transporting V-type ATPase, V0 domain; IEA:InterPro. DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell. DR GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro. DR CDD; cd18175; ATP-synt_Vo_c_ATP6C_rpt1; 1. DR CDD; cd18176; ATP-synt_Vo_c_ATP6C_rpt2; 1. DR Gene3D; 1.20.120.610; lithium bound rotor ring of v- atpase; 1. DR InterPro; IPR002379; ATPase_proteolipid_c-like_dom. DR InterPro; IPR000245; ATPase_proteolipid_csu. DR InterPro; IPR011555; ATPase_proteolipid_su_C_euk. DR InterPro; IPR035921; F/V-ATP_Csub_sf. DR NCBIfam; TIGR01100; V_ATP_synt_C; 1. DR PANTHER; PTHR10263; V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT; 1. DR PANTHER; PTHR10263:SF6; V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT; 1. DR Pfam; PF00137; ATP-synt_C; 2. DR PRINTS; PR00122; VACATPASE. DR SUPFAM; SSF81333; F1F0 ATP synthase subunit C; 1. DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1. PE 3: Inferred from homology; KW Hydrogen ion transport {ECO:0000256|RuleBase:RU363060}; KW Ion transport {ECO:0000256|ARBA:ARBA00023065, KW ECO:0000256|RuleBase:RU363060}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU363060}; KW Reference proteome {ECO:0000313|Proteomes:UP000007258}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU363060}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|RuleBase:RU363060}; KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU363060}; KW Vacuole {ECO:0000256|RuleBase:RU363060}. FT SIGNAL 1..20 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 21..187 FT /note="V-type proton ATPase proteolipid subunit" FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5010102866" FT TRANSMEM 33..55 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU363060" FT TRANSMEM 76..96 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU363060" FT TRANSMEM 116..138 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU363060" FT TRANSMEM 150..175 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU363060" FT DOMAIN 37..96 FT /note="V-ATPase proteolipid subunit C-like" FT /evidence="ECO:0000259|Pfam:PF00137" FT DOMAIN 116..175 FT /note="V-ATPase proteolipid subunit C-like" FT /evidence="ECO:0000259|Pfam:PF00137" SQ SEQUENCE 187 AA; 18872 MW; E6C9C2F9A6A2B450 CRC64; MKCQIASVVA AVALFGSAAA VSCSDKYPQS SAFFGSMGCA SALIFANLGS AYGTAKSGVG VAHLGILHAD RIMRGIVPVV MAGILGIYGL IVAVIINNNI KVEDNSYSSF AGYLHFGAGL AAGLSSLAAG LSIGIAGDAS ARAYGKQEKI FVAMILMLIF AEALGLYGLI IALLMNNTAG KVTAGCQ //