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Protein

V-type proton ATPase proteolipid subunit

Gene

LBRM_33_0850

Organism
Leishmania braziliensis
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Hydrogen ion transportUniRule annotation, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase proteolipid subunitUniRule annotation
Gene namesi
ORF Names:LBRM_33_0850Imported, LBRM_33_0860Imported
OrganismiLeishmania braziliensisImported
Taxonomic identifieri5660 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmaniaLeishmania braziliensis species complex
Proteomesi
  • UP000007258 Componenti: Chromosome 33

Subcellular locationi

  • Vacuole membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei33 – 55HelicalUniRule annotationAdd BLAST23
Transmembranei76 – 96HelicalUniRule annotationAdd BLAST21
Transmembranei116 – 138HelicalUniRule annotationAdd BLAST23
Transmembranei150 – 175HelicalUniRule annotationAdd BLAST26

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, VacuoleUniRule annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_500763482921 – 187V-type proton ATPase proteolipid subunitSequence analysisAdd BLAST167

Interactioni

Protein-protein interaction databases

STRINGi420245.XP_001567856.1.

Structurei

3D structure databases

ProteinModelPortaliA4HLC1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 96ATP-synt_CInterPro annotationAdd BLAST60
Domaini116 – 175ATP-synt_CInterPro annotationAdd BLAST60

Sequence similaritiesi

Belongs to the V-ATPase proteolipid subunit family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0232. Eukaryota.
COG0636. LUCA.
KOiK02155.
OMAiKPPYAFF.

Family and domain databases

InterProiIPR002379. ATPase_proteolipid_c-like_dom.
IPR000245. ATPase_proteolipid_csu.
IPR011555. ATPase_proteolipid_su_C_euk.
[Graphical view]
PfamiPF00137. ATP-synt_C. 2 hits.
[Graphical view]
PRINTSiPR00122. VACATPASE.
SUPFAMiSSF81333. SSF81333. 1 hit.
TIGRFAMsiTIGR01100. V_ATP_synt_C. 1 hit.

Sequencei

Sequence statusi: Complete.

A4HLC1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKCQIASVVA AVALFGSAAA VSCSDKYPQS SAFFGSMGCA SALIFANLGS
60 70 80 90 100
AYGTAKSGVG VAHLGILHAD RIMRGIVPVV MAGILGIYGL IVAVIINNNI
110 120 130 140 150
KVEDNSYSSF AGYLHFGAGL AAGLSSLAAG LSIGIAGDAS ARAYGKQEKI
160 170 180
FVAMILMLIF AEALGLYGLI IALLMNNTAG KVTAGCQ
Length:187
Mass (Da):18,872
Last modified:May 1, 2007 - v1
Checksum:iE6C9C2F9A6A2B450
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR799008 Genomic DNA. Translation: CAM40615.1.
FR799008 Genomic DNA. Translation: CAM40616.1.
RefSeqiXP_001567855.1. XM_001567805.1.
XP_001567856.1. XM_001567806.1.

Genome annotation databases

EnsemblProtistsiCAM40615; CAM40615; LBRM_33_0850.
CAM40616; CAM40616; LBRM_33_0860.
GeneIDi5418788.
5418789.
KEGGilbz:LBRM_33_0850.
lbz:LBRM_33_0860.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR799008 Genomic DNA. Translation: CAM40615.1.
FR799008 Genomic DNA. Translation: CAM40616.1.
RefSeqiXP_001567855.1. XM_001567805.1.
XP_001567856.1. XM_001567806.1.

3D structure databases

ProteinModelPortaliA4HLC1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi420245.XP_001567856.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiCAM40615; CAM40615; LBRM_33_0850.
CAM40616; CAM40616; LBRM_33_0860.
GeneIDi5418788.
5418789.
KEGGilbz:LBRM_33_0850.
lbz:LBRM_33_0860.

Phylogenomic databases

eggNOGiKOG0232. Eukaryota.
COG0636. LUCA.
KOiK02155.
OMAiKPPYAFF.

Family and domain databases

InterProiIPR002379. ATPase_proteolipid_c-like_dom.
IPR000245. ATPase_proteolipid_csu.
IPR011555. ATPase_proteolipid_su_C_euk.
[Graphical view]
PfamiPF00137. ATP-synt_C. 2 hits.
[Graphical view]
PRINTSiPR00122. VACATPASE.
SUPFAMiSSF81333. SSF81333. 1 hit.
TIGRFAMsiTIGR01100. V_ATP_synt_C. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiA4HLC1_LEIBR
AccessioniPrimary (citable) accession number: A4HLC1
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2007
Last sequence update: May 1, 2007
Last modified: November 2, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.