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Protein

DNA ligase

Gene

LBRM_30_3480

Organism
Leishmania braziliensis
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
ORF Names:LBRM_30_3480Imported
OrganismiLeishmania braziliensisImported
Taxonomic identifieri5660 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmaniaLeishmania braziliensis species complex
ProteomesiUP000007258 Componenti: Chromosome 30

Structurei

3D structure databases

ProteinModelPortaliA4HIT2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

InParanoidiA4HIT2.
KOiK10747.
OMAiPQVVIEV.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4HIT2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHQTTLDRLF VPVASVGVSN EADNSRKATK KVTTASNRED RKRPREEEKV
60 70 80 90 100
ASQCVSSTPT LDTATGRRTR WNEPTNAYYA QHVAEYKALI ANVPPPTATS
110 120 130 140 150
MAKLFQESTF DPVTTFESVW LPPRAPAALP TAGALEPVPF AVVVDVLADI
160 170 180 190 200
SATGSRLECL KQLTFLLLAV IERCPEDLVP VMYLVINKHA PQHEGVELGI
210 220 230 240 250
GDAVLVKAVA ECCGMTESRA KEEYRQSGDL AEIAQMHKQK QSTLMKPKAL
260 270 280 290 300
SARSVFKSYR EIAMMSGKDV VRRRSDLIKG LLRDAQGPEV NLIVRGLQQK
310 320 330 340 350
MRIGLAEPSA LAAVGYAFAL HFVGSAQMHT MSEVQLQTLL NSGADSLARI
360 370 380 390 400
FYEVPSLDVV LSAVLASGFM ILVPGSCIAK VHAKELSIRP GLPVKPQLAH
410 420 430 440 450
PTSGITVILD RLQGKKFTSE YKYDGERAQI HYSEDNGFHI FSRNSETHTG
460 470 480 490 500
KYPDVIAILP NTFDAAEVQS FIIDAEVVAV HPETGALQAF QVLQHRGRKN
510 520 530 540 550
IAEKDVSISV CLFVFDLLYL NGEPQLNKTL QQRRELLWRY IRPLPAKLCF
560 570 580 590 600
AAYLDSDDVE DVQKFLEKSI ADGCEGLMVK TLEEEATYTP AKRSHYWLKL
610 620 630 640 650
KKDYMDGVTD TLDLVPIAAF YGKGKRTGVF GGFLLACYDP KADEYQSICK
660 670 680 690 700
IGTGFQDEEL EKLTQSLKPF VVHDKPRYYR AGGEEPDVWL TEAQVWEVKA
710 720 730 740 750
ADLSVSPVHQ AAVGLVDPNK GIALRFPRYV RQREDKNPVD ATNTQQVAEM
760 770
YKAQSLAVQH DASGDAEWAV TRTETP
Length:776
Mass (Da):85,940
Last modified:May 1, 2007 - v1
Checksum:i97184D0C4CF51D6D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR799005 Genomic DNA. Translation: CAM40497.1.
RefSeqiXP_001566972.1. XM_001566922.2.

Genome annotation databases

GeneIDi5417873.
KEGGilbz:LBRM_30_3480.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR799005 Genomic DNA. Translation: CAM40497.1.
RefSeqiXP_001566972.1. XM_001566922.2.

3D structure databases

ProteinModelPortaliA4HIT2.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5417873.
KEGGilbz:LBRM_30_3480.

Phylogenomic databases

InParanoidiA4HIT2.
KOiK10747.
OMAiPQVVIEV.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MHOM/BR/75/M2904Imported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MHOM/BR/75/M2904Imported.

Entry informationi

Entry nameiA4HIT2_LEIBR
AccessioniPrimary (citable) accession number: A4HIT2
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2007
Last sequence update: May 1, 2007
Last modified: April 29, 2015
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.