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A4HIT2

- A4HIT2_LEIBR

UniProt

A4HIT2 - A4HIT2_LEIBR

Protein

DNA ligase

Gene

LBRM_30_3480

Organism
Leishmania braziliensis
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (01 May 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA ligation involved in DNA repair Source: InterPro
    2. DNA recombination Source: UniProtKB-KW
    3. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Gene namesi
    ORF Names:LBRM_30_3480Imported
    OrganismiLeishmania braziliensisImported
    Taxonomic identifieri5660 [NCBI]
    Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmaniaLeishmania braziliensis species complex
    ProteomesiUP000007258: Chromosome 30

    Structurei

    3D structure databases

    ProteinModelPortaliA4HIT2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    KOiK10747.
    OMAiLDPSGYN.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    InterProiIPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A4HIT2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHQTTLDRLF VPVASVGVSN EADNSRKATK KVTTASNRED RKRPREEEKV    50
    ASQCVSSTPT LDTATGRRTR WNEPTNAYYA QHVAEYKALI ANVPPPTATS 100
    MAKLFQESTF DPVTTFESVW LPPRAPAALP TAGALEPVPF AVVVDVLADI 150
    SATGSRLECL KQLTFLLLAV IERCPEDLVP VMYLVINKHA PQHEGVELGI 200
    GDAVLVKAVA ECCGMTESRA KEEYRQSGDL AEIAQMHKQK QSTLMKPKAL 250
    SARSVFKSYR EIAMMSGKDV VRRRSDLIKG LLRDAQGPEV NLIVRGLQQK 300
    MRIGLAEPSA LAAVGYAFAL HFVGSAQMHT MSEVQLQTLL NSGADSLARI 350
    FYEVPSLDVV LSAVLASGFM ILVPGSCIAK VHAKELSIRP GLPVKPQLAH 400
    PTSGITVILD RLQGKKFTSE YKYDGERAQI HYSEDNGFHI FSRNSETHTG 450
    KYPDVIAILP NTFDAAEVQS FIIDAEVVAV HPETGALQAF QVLQHRGRKN 500
    IAEKDVSISV CLFVFDLLYL NGEPQLNKTL QQRRELLWRY IRPLPAKLCF 550
    AAYLDSDDVE DVQKFLEKSI ADGCEGLMVK TLEEEATYTP AKRSHYWLKL 600
    KKDYMDGVTD TLDLVPIAAF YGKGKRTGVF GGFLLACYDP KADEYQSICK 650
    IGTGFQDEEL EKLTQSLKPF VVHDKPRYYR AGGEEPDVWL TEAQVWEVKA 700
    ADLSVSPVHQ AAVGLVDPNK GIALRFPRYV RQREDKNPVD ATNTQQVAEM 750
    YKAQSLAVQH DASGDAEWAV TRTETP 776
    Length:776
    Mass (Da):85,940
    Last modified:May 1, 2007 - v1
    Checksum:i97184D0C4CF51D6D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FR799005 Genomic DNA. Translation: CAM40497.1.
    RefSeqiXP_001566972.1. XM_001566922.2.

    Genome annotation databases

    GeneIDi5417873.
    KEGGilbz:LBRM_30_3480.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FR799005 Genomic DNA. Translation: CAM40497.1 .
    RefSeqi XP_001566972.1. XM_001566922.2.

    3D structure databases

    ProteinModelPortali A4HIT2.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 5417873.
    KEGGi lbz:LBRM_30_3480.

    Phylogenomic databases

    KOi K10747.
    OMAi LDPSGYN.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    InterProi IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MHOM/BR/75/M2904Imported.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MHOM/BR/75/M2904Imported.

    Entry informationi

    Entry nameiA4HIT2_LEIBR
    AccessioniPrimary (citable) accession number: A4HIT2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 1, 2007
    Last sequence update: May 1, 2007
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3