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Protein

DNA ligase

Gene

LBRM_30_3480

Organism
Leishmania braziliensis
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processDNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
ORF Names:LBRM_30_3480Imported
OrganismiLeishmania braziliensisImported
Taxonomic identifieri5660 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmaniaLeishmania braziliensis species complex
Proteomesi
  • UP000007258 Componenti: Chromosome 30

Organism-specific databases

EuPathDBiTriTrypDB:LbrM.30.3480

Interactioni

Protein-protein interaction databases

STRINGi420245.XP_001566972.1

Structurei

3D structure databases

ProteinModelPortaliA4HIT2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini503 – 639DNA_LIGASE_A3InterPro annotationAdd BLAST137

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0967 Eukaryota
COG1793 LUCA
InParanoidiA4HIT2
KOiK10747
OMAiWIKYKRD

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
InterProiView protein in InterPro
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS00333 DNA_LIGASE_A2, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

A4HIT2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHQTTLDRLF VPVASVGVSN EADNSRKATK KVTTASNRED RKRPREEEKV
60 70 80 90 100
ASQCVSSTPT LDTATGRRTR WNEPTNAYYA QHVAEYKALI ANVPPPTATS
110 120 130 140 150
MAKLFQESTF DPVTTFESVW LPPRAPAALP TAGALEPVPF AVVVDVLADI
160 170 180 190 200
SATGSRLECL KQLTFLLLAV IERCPEDLVP VMYLVINKHA PQHEGVELGI
210 220 230 240 250
GDAVLVKAVA ECCGMTESRA KEEYRQSGDL AEIAQMHKQK QSTLMKPKAL
260 270 280 290 300
SARSVFKSYR EIAMMSGKDV VRRRSDLIKG LLRDAQGPEV NLIVRGLQQK
310 320 330 340 350
MRIGLAEPSA LAAVGYAFAL HFVGSAQMHT MSEVQLQTLL NSGADSLARI
360 370 380 390 400
FYEVPSLDVV LSAVLASGFM ILVPGSCIAK VHAKELSIRP GLPVKPQLAH
410 420 430 440 450
PTSGITVILD RLQGKKFTSE YKYDGERAQI HYSEDNGFHI FSRNSETHTG
460 470 480 490 500
KYPDVIAILP NTFDAAEVQS FIIDAEVVAV HPETGALQAF QVLQHRGRKN
510 520 530 540 550
IAEKDVSISV CLFVFDLLYL NGEPQLNKTL QQRRELLWRY IRPLPAKLCF
560 570 580 590 600
AAYLDSDDVE DVQKFLEKSI ADGCEGLMVK TLEEEATYTP AKRSHYWLKL
610 620 630 640 650
KKDYMDGVTD TLDLVPIAAF YGKGKRTGVF GGFLLACYDP KADEYQSICK
660 670 680 690 700
IGTGFQDEEL EKLTQSLKPF VVHDKPRYYR AGGEEPDVWL TEAQVWEVKA
710 720 730 740 750
ADLSVSPVHQ AAVGLVDPNK GIALRFPRYV RQREDKNPVD ATNTQQVAEM
760 770
YKAQSLAVQH DASGDAEWAV TRTETP
Length:776
Mass (Da):85,940
Last modified:May 1, 2007 - v1
Checksum:i97184D0C4CF51D6D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR799005 Genomic DNA Translation: CAM40497.1
RefSeqiXP_001566972.1, XM_001566922.2

Genome annotation databases

EnsemblProtistsiCAM40497; CAM40497; LBRM_30_3480
GeneDBiLbrM.30.3480:pep
GeneIDi5417873
KEGGilbz:LBRM_30_3480

Similar proteinsi

Entry informationi

Entry nameiA4HIT2_LEIBR
AccessioniPrimary (citable) accession number: A4HIT2
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2007
Last sequence update: May 1, 2007
Last modified: April 25, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health