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A4HIT2

- A4HIT2_LEIBR

UniProt

A4HIT2 - A4HIT2_LEIBR

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Protein
DNA ligase
Gene
LBRM_30_3480
Organism
Leishmania braziliensis
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. DNA ligation involved in DNA repair Source: InterPro
  2. DNA recombination Source: UniProtKB-KW
  3. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
ORF Names:LBRM_30_3480Imported
OrganismiLeishmania braziliensis
Taxonomic identifieri5660 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmaniaLeishmania braziliensis species complex
ProteomesiUP000007258: Chromosome 30

Structurei

3D structure databases

ProteinModelPortaliA4HIT2.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

KOiK10747.
OMAiLDPSGYN.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4HIT2-1 [UniParc]FASTAAdd to Basket

« Hide

MHQTTLDRLF VPVASVGVSN EADNSRKATK KVTTASNRED RKRPREEEKV    50
ASQCVSSTPT LDTATGRRTR WNEPTNAYYA QHVAEYKALI ANVPPPTATS 100
MAKLFQESTF DPVTTFESVW LPPRAPAALP TAGALEPVPF AVVVDVLADI 150
SATGSRLECL KQLTFLLLAV IERCPEDLVP VMYLVINKHA PQHEGVELGI 200
GDAVLVKAVA ECCGMTESRA KEEYRQSGDL AEIAQMHKQK QSTLMKPKAL 250
SARSVFKSYR EIAMMSGKDV VRRRSDLIKG LLRDAQGPEV NLIVRGLQQK 300
MRIGLAEPSA LAAVGYAFAL HFVGSAQMHT MSEVQLQTLL NSGADSLARI 350
FYEVPSLDVV LSAVLASGFM ILVPGSCIAK VHAKELSIRP GLPVKPQLAH 400
PTSGITVILD RLQGKKFTSE YKYDGERAQI HYSEDNGFHI FSRNSETHTG 450
KYPDVIAILP NTFDAAEVQS FIIDAEVVAV HPETGALQAF QVLQHRGRKN 500
IAEKDVSISV CLFVFDLLYL NGEPQLNKTL QQRRELLWRY IRPLPAKLCF 550
AAYLDSDDVE DVQKFLEKSI ADGCEGLMVK TLEEEATYTP AKRSHYWLKL 600
KKDYMDGVTD TLDLVPIAAF YGKGKRTGVF GGFLLACYDP KADEYQSICK 650
IGTGFQDEEL EKLTQSLKPF VVHDKPRYYR AGGEEPDVWL TEAQVWEVKA 700
ADLSVSPVHQ AAVGLVDPNK GIALRFPRYV RQREDKNPVD ATNTQQVAEM 750
YKAQSLAVQH DASGDAEWAV TRTETP 776
Length:776
Mass (Da):85,940
Last modified:May 1, 2007 - v1
Checksum:i97184D0C4CF51D6D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FR799005 Genomic DNA. Translation: CAM40497.1.
RefSeqiXP_001566972.1. XM_001566922.2.

Genome annotation databases

GeneIDi5417873.
KEGGilbz:LBRM_30_3480.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FR799005 Genomic DNA. Translation: CAM40497.1 .
RefSeqi XP_001566972.1. XM_001566922.2.

3D structure databases

ProteinModelPortali A4HIT2.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5417873.
KEGGi lbz:LBRM_30_3480.

Phylogenomic databases

KOi K10747.
OMAi LDPSGYN.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProi IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MHOM/BR/75/M2904Imported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MHOM/BR/75/M2904Imported.

Entry informationi

Entry nameiA4HIT2_LEIBR
AccessioniPrimary (citable) accession number: A4HIT2
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2007
Last sequence update: May 1, 2007
Last modified: July 9, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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