A4HIP2 (A4HIP2_LEIBR) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Putative homoserine kinase EMBL CAM40456.1
EC=2.7.1.39 EMBL CAM40456.1

Gene names

ORF Names:

LBRM_30_3070 EMBL CAM40456.1

Organism

Leishmania braziliensis

Taxonomic identifier

5660 [NCBI]

Taxonomic lineage

Eukaryota › Euglenozoa › Kinetoplastida › Trypanosomatidae › Leishmania › Leishmania braziliensis species complex

Protein attributes

Sequence length	341 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the GHMP kinase family. RuleBase RU004209

Ontologies

Keywords
Ligand	ATP-binding RuleBase RU003563 Nucleotide-binding
Molecular function	Kinase RuleBase RU003563 EMBL CAM40456.1 Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	threonine metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW homoserine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A4HIP2 [UniParc]. Last modified May 1, 2007. Version 1. Checksum: 5289DA18BB63C88A	FASTA	341	36,439
	10 20 30 40 50 60 MSNGVATPLP RKVAVRVPAT TANIGPAYDT FGMALSIFME LTVELAETFS MTVTGEGHEH 70 80 90 100 110 120 ISTGEDNMVV QTCRIAFEEY AHKSMPPLKF IMHNNVPYRC GCGSSSAAAV AGFVAGMTLC 130 140 150 160 170 180 GLTMETQNRE ALLLAISKIE GHSDNAAPAI YGGIQLVYKK DEESLMTYHV PTPPNLAIVL 190 200 210 220 230 240 FVPHRLMKAS THVTRDLVPT TVSLRDAVHN ISSTAILTLA LSTGDLRMLK DASDCLHEQQ 250 260 270 280 290 300 RSSKLYPHYN ACAKAAREAG AVYSFLSGAG PSVCAMVPGR HGDFLSQPEG ERKAEMVAEA 310 320 330 340 MVKAAEAVGV HGRAIITIPS NLGAHLPGTT CIRPNIQYTS I

References

[1]

"Comparative genomic analysis of three Leishmania species that cause diverse human disease." Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A., Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A., Fraser A., Rajandream M.-A., Carver T., Norbertczak H., Chillingworth T., Hance Z. , Jagels K., Moule S., Ormond D., Rutter S., Sqaures R., Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S., Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P., Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R.O., Barrell B., Cruz A.K., Mottram J.C., Smith D.F., Berriman M. Nat. Genet. 39:839-847(2007) [PubMed: 17572675] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MHOM/BR/75/M2904.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FR799005 Genomic DNA. Translation: CAM40456.1.
RefSeq	XP_001566932.1. XM_001566882.1.
3D structure databases
ProteinModelPortal	A4HIP2.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5417832.
KEGG	lbz:LbrM30_V2.3070.
Organism-specific databases
EuPathDB	EupathDB:LbrM.30.3070.
Phylogenomic databases
HOGENOM	HBG646290.
OMA	FTVAWQD.
PhylomeDB	A4HIP2.
ProtClustDB	PTZ00299.
Family and domain databases
InterPro	IPR006204. GHMP_kinase. IPR013750. GHMP_kinase_C. IPR000870. Homoserine_kinase. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. [Graphical view]
Gene3D	G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
KO	K00872.
Pfam	PF08544. GHMP_kinases_C. 1 hit. PF00288. GHMP_kinases_N. 1 hit. [Graphical view]
PIRSF	PIRSF000676. Homoser_kin. 1 hit.
PRINTS	PR00958. HOMSERKINASE.
SUPFAM	SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMs	TIGR00191. ThrB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A4HIP2_LEIBR

Accession

Primary (citable) accession number: A4HIP2

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2007
Last sequence update:	May 1, 2007
Last modified:	November 16, 2011
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)