A4HF68 (A4HF68_LEIBR) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Putative kynureninase EMBL CAM39478.1
EC=3.7.1.3 EMBL CAM39478.1

Gene names

ORF Names:

LBRM_26_2160 EMBL CAM39478.1

Organism

Leishmania braziliensis

Taxonomic identifier

5660 [NCBI]

Taxonomic lineage

Eukaryota › Euglenozoa › Kinetoplastida › Trypanosomatidae › Leishmania › Leishmania braziliensis species complex

Protein attributes

Sequence length	468 AA.
Sequence status	Complete.
Protein existence	Predicted

Ontologies

Keywords
Molecular function	Hydrolase EMBL CAM39478.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	NAD biosynthetic process Inferred from electronic annotation. Source: InterPro tryptophan catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	kynureninase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A4HF68 [UniParc]. Last modified May 1, 2007. Version 1. Checksum: BEB182F7109451AA	FASTA	468	50,814
	10 20 30 40 50 60 MRNAAAETLL STVSATGMAL TEDGFAEHMD SVDPLREHRS SYHIPKMRDG TAFSYCAGNA 70 80 90 100 110 120 MGLQHIHVEA SVEVFLKKWR EQAVGGPCMQ PTPWPEIGQM CVKDMAAIVG AKDTEVTIMN 130 140 150 160 170 180 TLTVNLHLLL TAFYRTQGSK RKLMIAPHSF PSDGYCLLSL LETRGLNPGE DVIKITAPGT 190 200 210 220 230 240 RDWSDPATVI PTEAFLSVIE KRGDETAVLV VSAVQYLTGQ WFDIPAIVKA ARAKKIIVGV 250 260 270 280 290 300 DCSHAVGNVP LHLHDWDVDF AYWCTCKYLN SGPGSLSGLF VHNKHTPCTI PLECLNGLWS 310 320 330 340 350 360 SDIKSCFSEH RRFEPAPGAS PLQISTPSAA CHVILAPSLK LMASVGMEAI RQKSLLLTAY 370 380 390 400 410 420 LELLVSELIP PGCIDVVTPA NPNQRGAQLS LRILPNKLKL CQEAVSEYEC GAGGAAETDD 430 440 450 460 TALLQRQLLD KGVIIDMCSP DMVSIAPAPM YNSFADVLRV VRTLASLF

References

[1]

"Comparative genomic analysis of three Leishmania species that cause diverse human disease." Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A., Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A., Fraser A., Rajandream M.-A., Carver T., Norbertczak H., Chillingworth T., Hance Z. , Jagels K., Moule S., Ormond D., Rutter S., Sqaures R., Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S., Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P., Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R.O., Barrell B., Cruz A.K., Mottram J.C., Smith D.F., Berriman M. Nat. Genet. 39:839-847(2007) [PubMed: 17572675] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MHOM/BR/75/M2904.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FR799001 Genomic DNA. Translation: CAM39478.1.
RefSeq	XP_001562446.1. XM_001562396.1.
3D structure databases
ProteinModelPortal	A4HF68.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5416568.
KEGG	lbz:LbrM26_V2.2160.
Organism-specific databases
EuPathDB	EupathDB:LbrM.26.2160.
Phylogenomic databases
HOGENOM	HBG523016.
OMA	TAEAHKR.
PhylomeDB	A4HF68.
ProtClustDB	CLSZ2430281.
Family and domain databases
InterPro	IPR000192. Aminotrans_V/Cys_dSase. IPR010111. Kynureninase. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 2 hits.
KO	K01556.
PANTHER	PTHR14084. Kynureninase. 1 hit.
Pfam	PF00266. Aminotran_5. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR01814. Kynureninase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A4HF68_LEIBR

Accession

Primary (citable) accession number: A4HF68

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2007
Last sequence update:	May 1, 2007
Last modified:	November 16, 2011
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)