ID   A4HEZ0_LEIBR            Unreviewed;       477 AA.
AC   A4HEZ0;
DT   01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2007, sequence version 1.
DT   27-MAR-2024, entry version 84.
DE   SubName: Full=Putative DNA ligase {ECO:0000313|EMBL:CAM39399.1};
DE            EC=6.5.1.1 {ECO:0000313|EMBL:CAM39399.1};
GN   ORFNames=LBRM_26_1370 {ECO:0000313|EMBL:CAM39399.1};
OS   Leishmania braziliensis.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC   Leishmania braziliensis species complex.
OX   NCBI_TaxID=5660 {ECO:0000313|EMBL:CAM39399.1, ECO:0000313|Proteomes:UP000007258};
RN   [1] {ECO:0000313|EMBL:CAM39399.1, ECO:0000313|Proteomes:UP000007258}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM39399.1,
RC   ECO:0000313|Proteomes:UP000007258};
RX   PubMed=17572675; DOI=10.1038/ng2053;
RA   Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA   Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA   Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA   Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA   Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA   Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA   Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA   Mottram J.C., Smith D.F., Berriman M.;
RT   "Comparative genomic analysis of three Leishmania species that cause
RT   diverse human disease.";
RL   Nat. Genet. 39:839-847(2007).
RN   [2] {ECO:0000313|EMBL:CAM39399.1, ECO:0000313|Proteomes:UP000007258}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM39399.1,
RC   ECO:0000313|Proteomes:UP000007258};
RX   PubMed=22038252; DOI=10.1101/gr.122945.111;
RA   Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA   Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA   Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA   Hertz-Fowler C., Mottram J.C.;
RT   "Chromosome and gene copy number variation allow major structural change
RT   between species and strains of Leishmania.";
RL   Genome Res. 21:2129-2142(2011).
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DR   EMBL; FR799001; CAM39399.1; -; Genomic_DNA.
DR   RefSeq; XP_001562368.1; XM_001562318.2.
DR   AlphaFoldDB; A4HEZ0; -.
DR   STRING; 5660.A4HEZ0; -.
DR   GeneID; 5416489; -.
DR   KEGG; lbz:LBRM_26_1370; -.
DR   VEuPathDB; TriTrypDB:LbrM.26.1370; -.
DR   VEuPathDB; TriTrypDB:LBRM2903_260018800; -.
DR   InParanoid; A4HEZ0; -.
DR   OMA; VKAPRMV; -.
DR   Proteomes; UP000007258; Chromosome 26.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd08041; OBF_kDNA_ligase_like; 1.
DR   Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR029319; DNA_ligase_OB.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   PANTHER; PTHR47810; DNA LIGASE; 1.
DR   PANTHER; PTHR47810:SF3; LIGASE, PUTATIVE-RELATED; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF14743; DNA_ligase_OB_2; 1.
DR   SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR   PROSITE; PS00333; DNA_LIGASE_A2; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   4: Predicted;
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   Ligase {ECO:0000313|EMBL:CAM39399.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007258}.
FT   DOMAIN          266..416
FT                   /note="ATP-dependent DNA ligase family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50160"
SQ   SEQUENCE   477 AA;  54171 MW;  E7D21870796F4C8C CRC64;
     MSKLFGARGR RTLQQKRVYD QLKNTTIQDA FPHIAACWVG PCWGSVMQTP CNVSPVCMKM
     AVWRCSSCLQ EFEMVVGHFV DEGGVCPHCH NPQKRLDNVT LRNAQGELVI KKPQYIKAPR
     MIHSNYRSVL FTNPHWESLN IQPMLAQRWE LVVDELTKSS NGENGTTPDK HLLLASPKID
     GIRCMIGYNQ KLQEVQFFSR GGIVLECCHG LVPQLLPLFK EDPTLMLDGE LFAPECNFEQ
     LNGLVRRLNK KSSPKVMEAQ ARLLEYFAFD IMYSAQLSSP SAPFDERYQL LKKLIPVCGA
     KRISNYIHDD AKKKVIRAKH GSVATAANGQ AVKIYHVPAA QVHPSDMKDV LDEACSQGFE
     GVMIRLPKFP YEHGKRSFGL LKYKQMHDAE FKIVGFVPGE GKFKGALGAF ICETKDGKLF
     NTPPKVPYKR RIELWAHRKE FLSKYLTVQY QELSSQNVPR FPIAKAVRGS EDRQDWL
//