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Protein

Hexokinase

Gene

LBRM_21_0310

Organism
Leishmania braziliensis
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. hexokinase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotation, Transferase

Keywords - Biological processi

GlycolysisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
HexokinaseUniRule annotation (EC:2.7.1.1UniRule annotation)
Gene namesi
ORF Names:LBRM_21_0310Imported
OrganismiLeishmania braziliensisImported
Taxonomic identifieri5660 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmaniaLeishmania braziliensis species complex
ProteomesiUP000007258 Componenti: Chromosome 21

Family & Domainsi

Sequence similaritiesi

Belongs to the hexokinase family.UniRule annotation
Contains 1 hexokinase type-1 domain.UniRule annotation
Contains 1 hexokinase type-2 domain.UniRule annotation

Phylogenomic databases

InParanoidiA4HBM3.
KOiK00844.
OMAiCALAANQ.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
PROSITEiPS00378. HEXOKINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4HBM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASRVNNLMN HLAIRDSDSE EMRYIKQRLA LASLSTQFTM ASEKMKQLTM
60 70 80 90 100
YMVYEMVEGL EGRPSTVRML PSYVYTSDPA KATGVYYALD LGGTNFRVLR
110 120 130 140 150
VSLRSGKVDD RIDSKFVIPK SALTGNSANL FDFIAQSVKK MMSENAPEDL
160 170 180 190 200
EKRVPLGFTF SFPVDQKAVN KGLLIKWTKG FSTKNVEGND VVELLQGSLR
210 220 230 240 250
RMHINVNVVA LCNDTVGTLV ARYFVDTNAQ VGVIIGTGSN ACYFERASAV
260 270 280 290 300
TKDPAVCARG NAVTPINMEC GNFDSKYKYA LPTTVYDDEM DAITPNRDHQ
310 320 330 340 350
RQEKIVSGMY LGEISRRMIV HLAQLGCLPR DLVDGLGKPW AFESKHMGMV
360 370 380 390 400
AADQMPGLQF TRELIKRVAG VNVTDVADLH TIREICCLVR NRAAQQAAVL
410 420 430 440 450
SAAPMLKTRT QGLATVAVDG SVYEKVPSFQ RLYQECITGI LGPTSNAKVV
460 470
LQKDGSGVGA AMICALAANQ K
Length:471
Mass (Da):51,716
Last modified:May 1, 2007 - v1
Checksum:iEF8CD157DC94D66E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR798996 Genomic DNA. Translation: CAM38811.1.
RefSeqiXP_001564741.1. XM_001564691.1.

Genome annotation databases

GeneIDi5415296.
KEGGilbz:LBRM_21_0310.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR798996 Genomic DNA. Translation: CAM38811.1.
RefSeqiXP_001564741.1. XM_001564691.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5415296.
KEGGilbz:LBRM_21_0310.

Phylogenomic databases

InParanoidiA4HBM3.
KOiK00844.
OMAiCALAANQ.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
PROSITEiPS00378. HEXOKINASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MHOM/BR/75/M2904Imported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MHOM/BR/75/M2904Imported.

Entry informationi

Entry nameiA4HBM3_LEIBR
AccessioniPrimary (citable) accession number: A4HBM3
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2007
Last sequence update: May 1, 2007
Last modified: April 1, 2015
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.