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Protein

Phosphoglycerate kinase

Gene

LBRM_20_4190

Organism
Leishmania braziliensis
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase (LBRM_30_2950)
  2. Phosphoglycerate kinase (LBRM_20_4190), Phosphoglycerate kinase (LBRM_30_3420)
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. Pyruvate kinase (LBRM_34_0010), Pyruvate kinase, Pyruvate kinase (LBRM_34_0040), Pyruvate kinase (LBRM_34_0060)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei39SubstrateUniRule annotation1
Binding sitei132SubstrateUniRule annotation1
Binding sitei169SubstrateUniRule annotation1
Binding sitei220ATPUniRule annotation1
Binding sitei342ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi372 – 375ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotation, Transferase
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
Gene namesi
ORF Names:LBRM_20_4190Imported
OrganismiLeishmania braziliensisImported
Taxonomic identifieri5660 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmaniaLeishmania braziliensis species complex
Proteomesi
  • UP000007258 Componenti: Chromosome_20_34.1

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei446 – 469HelicalSequence analysisAdd BLAST24

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi420245.XP_001564699.2.

Structurei

3D structure databases

SMRiA4HBH9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni24 – 26Substrate bindingUniRule annotation3
Regioni62 – 65Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1367. Eukaryota.
COG0126. LUCA.
InParanoidiA4HBH9.
KOiK00927.

Family and domain databases

CDDicd00318. Phosphoglycerate_kinase. 1 hit.
Gene3Di3.40.50.1260. 2 hits.
HAMAPiMF_00145. Phosphoglyc_kinase. 1 hit.
InterProiView protein in InterPro
IPR027250. Pgk_euglenozoa.
IPR001576. Phosphoglycerate_kinase.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
IPR036043. Phosphoglycerate_kinase_sf.
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiView protein in Pfam
PF00162. PGK. 1 hit.
PIRSFiPIRSF000724. Pgk. 1 hit.
PIRSF500126. Pgk_euglenozoa. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiView protein in PROSITE
PS00111. PGLYCERATE_KINASE. 1 hit.

Sequencei

Sequence statusi: Complete.

A4HBH9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLVQKKSID DATLKGKKVL IRVDFNVPVK NGKITNDFRI RAALPTIQKV
60 70 80 90 100
LKEDGSCILM SHLGRPKGAK MSDPKPAKGV RGYEEAATLR PVAERVAELL
110 120 130 140 150
GRKVEFAPDC LDAALYVSKL KGGDVLLLEN VRFYTEEGSK KEEERDAMAK
160 170 180 190 200
VLASYADVYI SDAFGTAHRD SATMTGIPKV LGAGYAGYLM EKEINYFARV
210 220 230 240 250
LNNPPRPLVA IVGGAKVSDK IQLLDNMLDR INFLVIGGAM AYTFQKAQGY
260 270 280 290 300
KIGISMCEED KLDLAKSLLK KAQERGVQVL FPVDHVCHKE FKAVESPLVT
310 320 330 340 350
EGVDIPDGYM ALDIGPKTIR MYEDVIGRCN SAIWNGPMGV FEMACYSKGT
360 370 380 390 400
FAVAKAMGAG TQKNGLMSII GGGDSASAAE MSGEAKNMSH VSTGGGASLE
410 420 430 440 450
LLEGKTLPGV AVLTDKIVKE RAASSKGSFG GSSSRRESAP RRSGCAFGGA
460 470
SIVVEIIKLL GALAIGIFIG RRMSTKLLQ
Length:479
Mass (Da):51,326
Last modified:April 5, 2011 - v2
Checksum:iC05A6653789485C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR798994 Genomic DNA. Translation: CAM38765.2.
RefSeqiXP_001564699.2. XM_001564649.2.

Genome annotation databases

EnsemblProtistsiCAM38765; CAM38765; LBRM_20_4190.
GeneDBiLbrM.20.4190:pep.
GeneIDi5415250.
KEGGilbz:LBRM_20_4190.

Similar proteinsi

Entry informationi

Entry nameiA4HBH9_LEIBR
AccessioniPrimary (citable) accession number: A4HBH9
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2007
Last sequence update: April 5, 2011
Last modified: October 25, 2017
This is version 78 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported