LBRM_20_4190

Functionⁱ

Catalytic activityⁱ

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayⁱ: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:

Glyceraldehyde-3-phosphate dehydrogenase (LBRM_30_2950)
Phosphoglycerate kinase (LBRM_20_4190), Phosphoglycerate kinase (LBRM_30_3420)
no protein annotated in this organism
no protein annotated in this organism
Pyruvate kinase (LBRM_34_0010), Pyruvate kinase, Pyruvate kinase (LBRM_34_0040), Pyruvate kinase (LBRM_34_0060)

This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	39	SubstrateUniRule annotation	1
Binding siteⁱ	132	SubstrateUniRule annotation	1
Binding siteⁱ	169	SubstrateUniRule annotation	1
Binding siteⁱ	220	ATPUniRule annotation	1
Binding siteⁱ	342	ATPUniRule annotation	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	372 – 375	ATPUniRule annotation		4

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
phosphoglycerate kinase activity Source: UniProtKB-EC

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

glycolytic process Source: UniProtKB-UniPathway

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	KinaseUniRule annotation, Transferase
Ligand	ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayⁱ	UPA00109; UER00185.

UniPathwayⁱ

UPA00109; UER00185.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
Gene namesⁱ	ORF Names:LBRM_20_4190Imported
Organismⁱ	Leishmania braziliensisImported
Taxonomic identifierⁱ	5660 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Euglenozoa › Kinetoplastida › Trypanosomatidae › Leishmaniinae › Leishmania › Viannia › Leishmania braziliensis species complex
Proteomesⁱ	UP000007258 Componentⁱ: Chromosome_20_34.1

Subcellular locationⁱ

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	446 – 469	HelicalSequence analysisAdd BLAST		24

GO - Cellular componentⁱ

integral component of membrane Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Membrane

Interactionⁱ

Subunit structureⁱ

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGⁱ	420245.XP_001564699.2.

STRINGⁱ

420245.XP_001564699.2.

Structureⁱ

3D structure databases

SMRⁱ	A4HBH9.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	24 – 26	Substrate bindingUniRule annotation		3
Regionⁱ	62 – 65	Substrate bindingUniRule annotation		4

Sequence similaritiesⁱ

Belongs to the phosphoglycerate kinase family.UniRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGⁱ	KOG1367. Eukaryota. COG0126. LUCA.
InParanoidⁱ	A4HBH9.
KEGG Orthology (KO) More...KOⁱ	K00927.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00318. Phosphoglycerate_kinase. 1 hit.
Gene3Dⁱ	3.40.50.1260. 2 hits.
HAMAPⁱ	MF_00145. Phosphoglyc_kinase. 1 hit.
InterProⁱ	View protein in InterPro IPR027250. Pgk_euglenozoa. IPR001576. Phosphoglycerate_kinase. IPR015911. Phosphoglycerate_kinase_CS. IPR015824. Phosphoglycerate_kinase_N. IPR036043. Phosphoglycerate_kinase_sf.
PANTHERⁱ	PTHR11406. PTHR11406. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00162. PGK. 1 hit.
PIRSFⁱ	PIRSF000724. Pgk. 1 hit. PIRSF500126. Pgk_euglenozoa. 1 hit.
PRINTSⁱ	PR00477. PHGLYCKINASE.
SUPFAMⁱ	SSF53748. SSF53748. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00111. PGLYCERATE_KINASE. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

A4HBH9-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTLVQKKSID DATLKGKKVL IRVDFNVPVK NGKITNDFRI RAALPTIQKV 
        60         70         80         90        100
LKEDGSCILM SHLGRPKGAK MSDPKPAKGV RGYEEAATLR PVAERVAELL 
       110        120        130        140        150
GRKVEFAPDC LDAALYVSKL KGGDVLLLEN VRFYTEEGSK KEEERDAMAK 
       160        170        180        190        200
VLASYADVYI SDAFGTAHRD SATMTGIPKV LGAGYAGYLM EKEINYFARV 
       210        220        230        240        250
LNNPPRPLVA IVGGAKVSDK IQLLDNMLDR INFLVIGGAM AYTFQKAQGY 
       260        270        280        290        300
KIGISMCEED KLDLAKSLLK KAQERGVQVL FPVDHVCHKE FKAVESPLVT 
       310        320        330        340        350
EGVDIPDGYM ALDIGPKTIR MYEDVIGRCN SAIWNGPMGV FEMACYSKGT 
       360        370        380        390        400
FAVAKAMGAG TQKNGLMSII GGGDSASAAE MSGEAKNMSH VSTGGGASLE 
       410        420        430        440        450
LLEGKTLPGV AVLTDKIVKE RAASSKGSFG GSSSRRESAP RRSGCAFGGA 
       460        470 
SIVVEIIKLL GALAIGIFIG RRMSTKLLQ

Length:479

Mass (Da):51,326

Last modified:April 5, 2011 - v2

Checksum:ⁱC05A6653789485C9

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	FR798994 Genomic DNA. Translation: CAM38765.2.
NCBI Reference Sequences More...RefSeqⁱ	XP_001564699.2. XM_001564649.2.

Genome annotation databases

EnsemblProtistsⁱ	CAM38765; CAM38765; LBRM_20_4190.
GeneDBⁱ	LbrM.20.4190:pep.
GeneIDⁱ	5415250.
KEGGⁱ	lbz:LBRM_20_4190.

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
A4HBH9	A0A1E1IVI7 A0A088S8I8	Leishmania guyanensis Leishmania panamensis	479	UniRef90_A0A1E1IVI7	Cluster: Phosphoglycerate kinase	3

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
A4HBH9	P08966 A0A0N0P4S0 A0A088S8I8 A0A1E1IVI7 A0A0S4JE17 A0A1X0NWU8 V5BAG7 Q4D192 Q95PK9 Q4DNV7 +35	Crithidia fasciculata Leptomonas seymouri Leishmania panamensis Leishmania guyanensis Bodo saltans (Flagellated protozoan) Trypanosoma theileri Trypanosoma cruzi Dm28c Trypanosoma cruzi (strain CL Brener) Trypanosoma cruzi Trypanosoma cruzi marinkellei And more	417	UniRef50_P08966	Cluster: Phosphoglycerate kinase, cytosolic	46

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	FR798994 Genomic DNA. Translation: CAM38765.2.
NCBI Reference Sequences More...RefSeqⁱ	XP_001564699.2. XM_001564649.2.

3D structure databases

SMRⁱ	A4HBH9.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	420245.XP_001564699.2.

STRINGⁱ

420245.XP_001564699.2.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblProtistsⁱ	CAM38765; CAM38765; LBRM_20_4190.
GeneDBⁱ	LbrM.20.4190:pep.
GeneIDⁱ	5415250.
KEGGⁱ	lbz:LBRM_20_4190.

Phylogenomic databases

eggNOGⁱ	KOG1367. Eukaryota. COG0126. LUCA.
InParanoidⁱ	A4HBH9.
KEGG Orthology (KO) More...KOⁱ	K00927.

Enzyme and pathway databases

UniPathwayⁱ	UPA00109; UER00185.

UniPathwayⁱ

UPA00109; UER00185.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00318. Phosphoglycerate_kinase. 1 hit.
Gene3Dⁱ	3.40.50.1260. 2 hits.
HAMAPⁱ	MF_00145. Phosphoglyc_kinase. 1 hit.
InterProⁱ	View protein in InterPro IPR027250. Pgk_euglenozoa. IPR001576. Phosphoglycerate_kinase. IPR015911. Phosphoglycerate_kinase_CS. IPR015824. Phosphoglycerate_kinase_N. IPR036043. Phosphoglycerate_kinase_sf.
PANTHERⁱ	PTHR11406. PTHR11406. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00162. PGK. 1 hit.
PIRSFⁱ	PIRSF000724. Pgk. 1 hit. PIRSF500126. Pgk_euglenozoa. 1 hit.
PRINTSⁱ	PR00477. PHGLYCKINASE.
SUPFAMⁱ	SSF53748. SSF53748. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00111. PGLYCERATE_KINASE. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A4HBH9_LEIBR
Accessionⁱ	A4HBH9Primary (citable) accession number: A4HBH9
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	May 1, 2007
	Last sequence update:	April 5, 2011
	Last modified:	October 25, 2017
	This is version 78 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A4HBH9 (A4HBH9_LEIBR)

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Phosphoglycerate kinase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: glycolysis

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

Pathwayⁱ: glycolysis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ