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A4H9H8 (CISY_LEIBR) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable citrate synthase, mitochondrial

EC=2.3.3.1
Gene names
ORF Names:LbrM18_V2.0760, LbrM_18_0760
OrganismLeishmania braziliensis [Reference proteome]
Taxonomic identifier5660 [NCBI]
Taxonomic lineageEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmaniaLeishmania braziliensis species complex

Protein attributes

Sequence length470 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.

Subunit structure

Homodimer By similarity.

Subcellular location

Mitochondrion matrix By similarity.

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Sequence similarities

Belongs to the citrate synthase family.

Ontologies

Keywords
   Biological processTricarboxylic acid cycle
   Cellular componentMitochondrion
   DomainTransit peptide
   Molecular functionTransferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcellular carbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

tricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentmitochondrial matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncitrate (Si)-synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential
Chain? – 470Probable citrate synthase, mitochondrialPRO_0000291604

Sites

Active site2971 By similarity
Active site3511 By similarity
Active site4061 By similarity

Sequences

Sequence LengthMass (Da)Tools
A4H9H8 [UniParc].

Last modified May 1, 2007. Version 1.
Checksum: D1EFE121FC034466

FASTA47051,957
        10         20         30         40         50         60 
MRAARCSIIR GAAGLRMASS VMSEMKEQML KRSKVEKQTI SELRKKHGDV KLSDASIDAA 

        70         80         90        100        110        120 
YCGMRGITGL VYEPSLLDPV EGIRFRNRTI PECQEVLPKA PNGCETLPEA MFWLLMTGEV 

       130        140        150        160        170        180 
PTAEQARALN AELHRRADPV AIAAAQKAIA ALPASTHPMT AFSVGVLALQ TYSKFAAAYA 

       190        200        210        220        230        240 
TGKSNKTTYW EYALEDSLDM LARTPAVAAM IYNRVTKGRA EVAASSNSEL DWAANFSNML 

       250        260        270        280        290        300 
GFKDNEFWEC MRLYLSIHVD HEGGNVSAHT TTLVASALSD PYLAFSAGLN GLAGPLHGLA 

       310        320        330        340        350        360 
NQEVLKYLLS MQDRVKADGV NVCDEAALEV ALTKYTWELL NSGQVVPGYG HAVLRKVDPR 

       370        380        390        400        410        420 
YTCLRNFCLR HHFEDDLFKL INIIYKIMPG ILTEHGKTKN PYPNVDAHSG VLLQHYGLTE 

       430        440        450        460        470 
QDYYTVLFGL SRQMGVMAGV VWDRLQGRPL ERPKSITTEM LAKKYLCTPR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FR798992 Genomic DNA. Translation: CAM38050.1.
RefSeqXP_001564000.1. XM_001563950.1.

3D structure databases

ProteinModelPortalA4H9H8.
SMRA4H9H8. Positions 23-463.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5414535.
KEGGlbz:LBRM_18_0760.

Phylogenomic databases

KOK01647.
OMAELIYEDC.
ProtClustDBCLSZ2438192.

Enzyme and pathway databases

UniPathwayUPA00223; UER00717.

Family and domain databases

Gene3D1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProIPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
[Graphical view]
PANTHERPTHR11739. PTHR11739. 1 hit.
PfamPF00285. Citrate_synt. 1 hit.
[Graphical view]
PRINTSPR00143. CITRTSNTHASE.
SUPFAMSSF48256. SSF48256. 1 hit.
PROSITEPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCISY_LEIBR
AccessionPrimary (citable) accession number: A4H9H8
Entry history
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: May 1, 2007
Last modified: October 16, 2013
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways