SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A4H9H8

- CISY_LEIBR

UniProt

A4H9H8 - CISY_LEIBR

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Probable citrate synthase, mitochondrial

Gene
LbrM18_V2.0760, LbrM_18_0760
Organism
Leishmania braziliensis
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei297 – 2971 By similarity
Active sitei351 – 3511 By similarity
Active sitei406 – 4061 By similarity

GO - Molecular functioni

  1. transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer Source: InterPro

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Tricarboxylic acid cycle

Enzyme and pathway databases

UniPathwayiUPA00223; UER00717.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable citrate synthase, mitochondrial (EC:2.3.3.16)
Gene namesi
ORF Names:LbrM18_V2.0760, LbrM_18_0760
OrganismiLeishmania braziliensis
Taxonomic identifieri5660 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmaniaLeishmania braziliensis species complex
ProteomesiUP000007258: Chromosome 18

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 470Probable citrate synthase, mitochondrialPRO_0000291604
Transit peptidei1 – ?Mitochondrion Reviewed prediction

Interactioni

Subunit structurei

Homodimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliA4H9H8.
SMRiA4H9H8. Positions 23-463.

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.

Keywords - Domaini

Transit peptide

Phylogenomic databases

KOiK01647.
OMAiELIYEDC.

Family and domain databases

Gene3Di1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A4H9H8-1 [UniParc]FASTAAdd to Basket

« Hide

MRAARCSIIR GAAGLRMASS VMSEMKEQML KRSKVEKQTI SELRKKHGDV    50
KLSDASIDAA YCGMRGITGL VYEPSLLDPV EGIRFRNRTI PECQEVLPKA 100
PNGCETLPEA MFWLLMTGEV PTAEQARALN AELHRRADPV AIAAAQKAIA 150
ALPASTHPMT AFSVGVLALQ TYSKFAAAYA TGKSNKTTYW EYALEDSLDM 200
LARTPAVAAM IYNRVTKGRA EVAASSNSEL DWAANFSNML GFKDNEFWEC 250
MRLYLSIHVD HEGGNVSAHT TTLVASALSD PYLAFSAGLN GLAGPLHGLA 300
NQEVLKYLLS MQDRVKADGV NVCDEAALEV ALTKYTWELL NSGQVVPGYG 350
HAVLRKVDPR YTCLRNFCLR HHFEDDLFKL INIIYKIMPG ILTEHGKTKN 400
PYPNVDAHSG VLLQHYGLTE QDYYTVLFGL SRQMGVMAGV VWDRLQGRPL 450
ERPKSITTEM LAKKYLCTPR 470
Length:470
Mass (Da):51,957
Last modified:May 1, 2007 - v1
Checksum:iD1EFE121FC034466
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FR798992 Genomic DNA. Translation: CAM38050.1.
RefSeqiXP_001564000.1. XM_001563950.1.

Genome annotation databases

GeneIDi5414535.
KEGGilbz:LBRM_18_0760.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FR798992 Genomic DNA. Translation: CAM38050.1 .
RefSeqi XP_001564000.1. XM_001563950.1.

3D structure databases

ProteinModelPortali A4H9H8.
SMRi A4H9H8. Positions 23-463.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5414535.
KEGGi lbz:LBRM_18_0760.

Phylogenomic databases

KOi K01647.
OMAi ELIYEDC.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER00717 .

Family and domain databases

Gene3Di 1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
[Graphical view ]
PANTHERi PTHR11739. PTHR11739. 1 hit.
Pfami PF00285. Citrate_synt. 1 hit.
[Graphical view ]
PRINTSi PR00143. CITRTSNTHASE.
SUPFAMi SSF48256. SSF48256. 1 hit.
PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MHOM/BR/75/M2904.

Entry informationi

Entry nameiCISY_LEIBR
AccessioniPrimary (citable) accession number: A4H9H8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: May 1, 2007
Last modified: June 11, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi