A4H7V2 (A4H7V2_LEIBR) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Serine hydroxymethyltransferase RuleBase RU000585
EC=2.1.2.1 RuleBase RU000585

Gene names

Name:	SHMT-S EMBL CAM37619.1
ORF Names:	LBRM_14_1490 EMBL CAM37619.1

Organism

Leishmania braziliensis

Taxonomic identifier

5660 [NCBI]

Taxonomic lineage

Eukaryota › Euglenozoa › Kinetoplastida › Trypanosomatidae › Leishmania › Leishmania braziliensis species complex

Protein attributes

Sequence length	465 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Interconversion of serine and glycine By similarity. RuleBase RU000585
Catalytic activity	5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. RuleBase RU000585
Cofactor	Pyridoxal phosphate By similarity. RuleBase RU000585
Pathway	One-carbon metabolism; tetrahydrofolate pathway. RuleBase RU000585
Sequence similarities	Belongs to the SHMT family. RuleBase RU004104

Ontologies

Keywords
Biological process	One-carbon metabolism RuleBase RU000585
Ligand	Pyridoxal phosphate RuleBase RU000585
Molecular function	Transferase RuleBase RU000585 EMBL CAM37619.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	L-serine metabolic process Inferred from electronic annotation. Source: InterPro glycine metabolic process Inferred from electronic annotation. Source: InterPro one-carbon metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	glycine hydroxymethyltransferase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A4H7V2 [UniParc]. Last modified May 1, 2007. Version 1. Checksum: 88E9CA05B8DB456F	FASTA	465	50,897
	10 20 30 40 50 60 MASLLPTLAE QDPELANMIE LEMSRQFRGL EMIASENLTS KAVLECLGSA LTNKYAEGEP 70 80 90 100 110 120 GNRYYGGTVY VDMVENLAKK RALAAFGLDP EVWGVNVQPY SGSPANFAAY TALLEPYSRI 130 140 150 160 170 180 MGLDLPSGGH LTHGFYTPKK KVSATSIYFE SFPYRVKEDG LIDYDTLESV ALVFRPQMII 190 200 210 220 230 240 AGASAYARDF DYERFRHICD EVGSLLLMDM AHTAGLIAGG ALKSPFPYAD VVTTTTHKSL 250 260 270 280 290 300 RGPRAGMIFY RKKDFQGKPT DYENRINQAV FPGCQGGPHE HQIAAIATQM REVCTPEWKV 310 320 330 340 350 360 YAKQVQSNAR TLAAALSAKG HKFVSGGTDN HLLLWNVRVH GLTGSKMEKL LDAVSVSVNK 370 380 390 400 410 420 NTIPGDKSAM TPGGIRVGTL SLTSRGMVEA DMRVIAEFLD RAIELAKQIQ TEVGSAKLND 430 440 450 460 FVEALPKYSG VAALRRDVEA FATTFAIPTF DVARIKYQGD PPKEL

References

[1]

"Comparative genomic analysis of three Leishmania species that cause diverse human disease." Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A., Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A., Fraser A., Rajandream M.-A., Carver T., Norbertczak H., Chillingworth T., Hance Z. , Jagels K., Moule S., Ormond D., Rutter S., Sqaures R., Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S., Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P., Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R.O., Barrell B., Cruz A.K., Mottram J.C., Smith D.F., Berriman M. Nat. Genet. 39:839-847(2007) [PubMed: 17572675] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MHOM/BR/75/M2904.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FR798988 Genomic DNA. Translation: CAM37619.1.
RefSeq	XP_001563435.1. XM_001563385.1.
3D structure databases
ProteinModelPortal	A4H7V2.
SMR	A4H7V2. Positions 6-449.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5413946.
KEGG	lbz:LbrM14_V2.1490.
Organism-specific databases
EuPathDB	EupathDB:LbrM.14.1490.
Phylogenomic databases
HOGENOM	HBG301263.
OMA	LELCSIA.
PhylomeDB	A4H7V2.
ProtClustDB	PTZ00094.
Family and domain databases
HAMAP	MF_00051. SHMT. [Tree]
InterPro	IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. IPR001085. Ser_HO-MeTrfase. IPR019798. Ser_HO-MeTrfase_PLP_BS. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
KO	K00600.
PANTHER	PTHR11680. Gly_HO-Metrfase. 1 hit.
Pfam	PF00464. SHMT. 1 hit. [Graphical view]
PIRSF	PIRSF000412. SHMT. 1 hit.
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
PROSITE	PS00096. SHMT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A4H7V2_LEIBR

Accession

Primary (citable) accession number: A4H7V2

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2007
Last sequence update:	May 1, 2007
Last modified:	December 14, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)