A4H6W2 (A4H6W2_LEIBR) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Glucose-6-phosphate isomerase RuleBase RU000612
EC=5.3.1.9 RuleBase RU000612

Gene names

Name:	PGI EMBL CAM37422.1
Synonyms:	GPI EMBL ABU25162.1
ORF Names:	LBRM_12_0490 EMBL CAM37422.1

Organism

Leishmania braziliensis

Taxonomic identifier

5660 [NCBI]

Taxonomic lineage

Eukaryota › Euglenozoa › Kinetoplastida › Trypanosomatidae › Leishmania › Leishmania braziliensis species complex

Protein attributes

Sequence length	581 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. RuleBase RU000612
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. RuleBase RU000612
Subcellular location	Cytoplasm By similarity RuleBase RU003642.
Sequence similarities	Belongs to the GPI family. RuleBase RU000612

Ontologies

Keywords
Biological process	Gluconeogenesis RuleBase RU000612 Glycolysis RuleBase RU000612
Molecular function	Isomerase RuleBase RU000612 EMBL CAM37422.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A4H6W2 [UniParc]. Last modified May 1, 2007. Version 1. Checksum: 61CADFD8D2C48587	FASTA	581	64,665
	10 20 30 40 50 60 MATATFNAPY EIARKTKVLG ASDSSLSKLS AWKRLEFLYE KYGNESILSH FEKDQQRFSR 70 80 90 100 110 120 YSIEVPLQCD DNFLFLDYSK SHINDEVKDA LVALAEERGV RAFIKAMFDG QQVNSTEKRA 130 140 150 160 170 180 VLHVALRNRS NRAINVNGKD IMTDVNLVLA QMKDFTDKVR SGEWKGQTGK SIHYIVNVGI 190 200 210 220 230 240 GGSDLGPVMV YESLKPFSMR DMHCFFVSNV DGTHMAEVLK QVNMEETIFI IASKTFTTQE 250 260 270 280 290 300 TLTNAMSARN AFIDYLKSNN IPSDGAVAKH FVAISTNAKE VREFGIDTAN MFEFWDWVGG 310 320 330 340 350 360 RYSVWSAIGL SVMLSIGYEN FVEFLTGAHV IDNHFASAPV EQNLPMMLAL VGIWYNNFFG 370 380 390 400 410 420 AETQAVLPYD QYLWRLPAYL QQLDMESNGK GVTKKSGAVT VQTGPIIFGE AGTNGQHAFY 430 440 450 460 470 480 QLIHQGTKII PCDFIGCVQT QNRVGDHHRI LMSNFFAQTE ALMVGKSAEE VRQELVKSGM 490 500 510 520 530 540 PSDAIESLLP HKTFTGSRPS NSILVNALTP RALGAIIAMY EHKVLVQGAI WGINSYDQWG 550 560 570 580 VELGKVLAKS ILPQLKSGNI VSNHDGSTNG LINMFNTRAH L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Typing of four genetic loci discriminates among closely related species of New World Leishmania." Tsukayama P., Lucas C., Bacon D.J. Int. J. Parasitol. 39:355-362(2009) [PubMed: 18817779] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: MHOM/BR/84/LTB300 EMBL ABU25162.1 and MHOM/PE/88/BAA2072 EMBL ABU25163.1.
[2]	"Comparative genomic analysis of three Leishmania species that cause diverse human disease." Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A., Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A., Fraser A., Rajandream M.-A., Carver T., Norbertczak H., Chillingworth T., Hance Z. , Jagels K., Moule S., Ormond D., Rutter S., Sqaures R., Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S., Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P., Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R.O., Barrell B., Cruz A.K., Mottram J.C., Smith D.F., Berriman M. Nat. Genet. 39:839-847(2007) [PubMed: 17572675] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MHOM/BR/75/M2904.

Cross-references

Sequence databases
EMBL GenBank DDBJ	EU053101 Genomic DNA. Translation: ABU25162.1. EU053102 Genomic DNA. Translation: ABU25163.1. FR798986 Genomic DNA. Translation: CAM37422.1.
RefSeq	XP_001563099.1. XM_001563049.1.
3D structure databases
ProteinModelPortal	A4H6W2.
SMR	A4H6W2. Positions 25-580.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5413590.
KEGG	lbz:LbrM12_V2.0490.
Organism-specific databases
EuPathDB	EupathDB:LbrM.12.0490.
Phylogenomic databases
HOGENOM	HBG352954.
OMA	GPKIVSQ.
PhylomeDB	A4H6W2.
ProtClustDB	CLSZ2430346.
Family and domain databases
HAMAP	MF_00473. G6P_isomerase. [Tree]
InterPro	IPR001672. G6P_Isomerase. IPR023096. G6P_Isomerase_C. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
Gene3D	G3DSA:1.10.1390.10. G6P_Isomerase_C. 1 hit.
KO	K01810.
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A4H6W2_LEIBR

Accession

Primary (citable) accession number: A4H6W2

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2007
Last sequence update:	May 1, 2007
Last modified:	December 14, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)