A4H6N4 (A4H6N4_LEIBR) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Putative lanosterol 14-alpha-demethylase EMBL CAM41988.1
EC=1.14.13.70 EMBL CAM41988.1

Gene names

ORF Names:

LBRM_11_0880 EMBL CAM41988.1

Organism

Leishmania braziliensis

Taxonomic identifier

5660 [NCBI]

Taxonomic lineage

Eukaryota › Euglenozoa › Kinetoplastida › Trypanosomatidae › Leishmania › Leishmania braziliensis species complex

Protein attributes

Sequence length	479 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the cytochrome P450 family. RuleBase RU000461

Ontologies

Keywords
Ligand	Heme SAAS SAAS002403 RuleBase RU000461 Iron Metal-binding
Molecular function	Methyltransferase EMBL CAM41988.1 Oxidoreductase EMBL CAM41988.1 Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro methyltransferase activity Inferred from electronic annotation. Source: UniProtKB-KW sterol 14-demethylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A4H6N4 [UniParc]. Last modified May 1, 2007. Version 1. Checksum: 827A5E54701E8E48	FASTA	479	54,161
	10 20 30 40 50 60 MIGELLLLLA AGLALYGWYF CQSFNTTRAT DPPVVRCTTP FVGHILQFGK DPLGFMLNAK 70 80 90 100 110 120 RKYGGIFTMN VCGNRITIVG DVHQHSKFFT PRNEILSPRE VYSFMVPVFG EGVAYAAPYP 130 140 150 160 170 180 RMREQLNFLA EELTVAKFQN FAPSIQHEVR KFMKANWDKD EGEINILEDC SAMIINTACQ 190 200 210 220 230 240 CLFGEDLRKR LDARQFAQLL ARMESCLIPA AVFLPWILKL PLPQSYRCRD ARAELQDVLS 250 260 270 280 290 300 EIIIAREKEE AQKDNSTSDL LAGLLGAVYR DGTRMSQHEV CGMIVAAMFA GQHTSTITTT 310 320 330 340 350 360 WSLLHLMDPR NKKHLMKLHE EIDEFPAQLN YDNVMEEMPF AEKCARESIR RDPPLVMLMR 370 380 390 400 410 420 KVLKPVQVGK YVVPEGDIIA CSPLLSHQDE EAFPNPREWN PERNMKLVDG AFCGFGAGVH 430 440 450 460 470 KCIGEKFGLL QVKTVLATVL REYDFELLGS LPEPNYHTMV VGPTASQCRV KYIKKKATA

References

[1]

"Comparative genomic analysis of three Leishmania species that cause diverse human disease." Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A., Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A., Fraser A., Rajandream M.-A., Carver T., Norbertczak H., Chillingworth T., Hance Z. , Jagels K., Moule S., Ormond D., Rutter S., Sqaures R., Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S., Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P., Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R.O., Barrell B., Cruz A.K., Mottram J.C., Smith D.F., Berriman M. Nat. Genet. 39:839-847(2007) [PubMed: 17572675] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MHOM/BR/75/M2904.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FR798985 Genomic DNA. Translation: CAM41988.1.
RefSeq	XP_001563021.1. XM_001562971.1.
3D structure databases
ProteinModelPortal	A4H6N4.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5413512.
KEGG	lbz:LbrM11_V2.0880.
Organism-specific databases
EuPathDB	EupathDB:LbrM.11.0880.
Phylogenomic databases
HOGENOM	HBG566517.
OMA	AMIINTA.
PhylomeDB	A4H6N4.
ProtClustDB	CLSZ2443033.
Family and domain databases
InterPro	IPR001128. Cyt_P450. IPR017972. Cyt_P450_CS. IPR002403. Cyt_P450_E_grp-IV. [Graphical view]
Gene3D	G3DSA:1.10.630.10. Cyt_P450. 1 hit.
KO	K05917.
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00465. EP450IV.
SUPFAM	SSF48264. Cytochrome_P450. 1 hit.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A4H6N4_LEIBR

Accession

Primary (citable) accession number: A4H6N4

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2007
Last sequence update:	May 1, 2007
Last modified:	December 14, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)