ID   A4H6G1_LEIBR            Unreviewed;       771 AA.
AC   A4H6G1;
DT   01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2007, sequence version 1.
DT   27-MAR-2024, entry version 62.
DE   SubName: Full=Putative DNA ligase {ECO:0000313|EMBL:CAM41913.1};
DE            EC=6.5.1.1 {ECO:0000313|EMBL:CAM41913.1};
GN   ORFNames=LBRM_11_0130 {ECO:0000313|EMBL:CAM41913.1};
OS   Leishmania braziliensis.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC   Leishmania braziliensis species complex.
OX   NCBI_TaxID=5660 {ECO:0000313|EMBL:CAM41913.1, ECO:0000313|Proteomes:UP000007258};
RN   [1] {ECO:0000313|EMBL:CAM41913.1, ECO:0000313|Proteomes:UP000007258}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM41913.1,
RC   ECO:0000313|Proteomes:UP000007258};
RX   PubMed=17572675; DOI=10.1038/ng2053;
RA   Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA   Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA   Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA   Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA   Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA   Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA   Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA   Mottram J.C., Smith D.F., Berriman M.;
RT   "Comparative genomic analysis of three Leishmania species that cause
RT   diverse human disease.";
RL   Nat. Genet. 39:839-847(2007).
RN   [2] {ECO:0000313|EMBL:CAM41913.1, ECO:0000313|Proteomes:UP000007258}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM41913.1,
RC   ECO:0000313|Proteomes:UP000007258};
RX   PubMed=22038252; DOI=10.1101/gr.122945.111;
RA   Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA   Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA   Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA   Hertz-Fowler C., Mottram J.C.;
RT   "Chromosome and gene copy number variation allow major structural change
RT   between species and strains of Leishmania.";
RL   Genome Res. 21:2129-2142(2011).
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DR   EMBL; FR798985; CAM41913.1; -; Genomic_DNA.
DR   RefSeq; XP_001562948.1; XM_001562898.1.
DR   AlphaFoldDB; A4H6G1; -.
DR   GeneID; 5413437; -.
DR   KEGG; lbz:LBRM_11_0130; -.
DR   VEuPathDB; TriTrypDB:LbrM.11.0130; -.
DR   VEuPathDB; TriTrypDB:LBRM2903_110006200; -.
DR   InParanoid; A4H6G1; -.
DR   OMA; LFWIEEE; -.
DR   Proteomes; UP000007258; Chromosome 11.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   PANTHER; PTHR47810; DNA LIGASE; 1.
DR   PANTHER; PTHR47810:SF5; LIGASE, PUTATIVE-RELATED; 1.
DR   SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
PE   4: Predicted;
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   Ligase {ECO:0000313|EMBL:CAM41913.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007258}.
FT   REGION          35..57
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          94..125
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          173..208
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          624..648
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        624..639
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   771 AA;  84006 MW;  ABACAB3983326D70 CRC64;
     MLHSCRRLAR TLPFMPMALS SLNLLEHRLQ ATGLGGTTST PAAPKSLAAP SLSSDNSESE
     KMRQLKWFSS SVDAPFFISP KHDGVRLISY VPPTTATTPP LSSSQHASNK KRTKRGATTG
     KSPPLTTCYS RYGRPIYGLF WIEEELRLLR ALCGDASLII DGELYLHRTD MEASQAGQQG
     QPKAPDSRRK KPARTGLPSS NADGARPLPT RADTFHSGFL AVSALVHRFR GSASQCTSKE
     GVLQYVPSLP RLCVFDVPSY SPCANPLAPL TRTLPTAISA VSRLHSSTKA SVTDGGGSQR
     VLAEIQRVRS DVISALRLND VEQLRIVPNL TLFSHRLRTM HYLFELLSRA MESPVLLQHF
     CPTAASLCNA RKTRAAGDWR TPTAIAAQMQ PLHSGIAPYH GGHFVSRIPY QLVASLEDTT
     QRVLPVYLNA GYEGAVIRAP VNTYEFKEKT KGTLAALVAP LLRATETTKT RRSLHLRGKN
     AGGREVSGRS ARNRAALLLS LNTGTARGAA TPLMVRAYRG NVPCCEPAQP ASPADAGLTD
     AELDVLDVVA MGRRAILQSA KLTWRSMTAV KVLTYHDREY PILRPLLKEP STNPRTRELV
     SIPRARARAL GYLIKPNADV AVSSGDRETT LTPATPQRER KNTMRNDTTT DTGAAVCFYG
     LQCLAENGLV FNVSLPKLTL AQQRTLLQHL LSAGRDVMRN RSPSASPTKT RNNNKKLNVK
     GPYEEAASLR PSKMVSLTGL YATVKFSTLT EHGLPRFGSV KAIRGGKGWF M
//