A4GYX1 (NU1C_POPTR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
NAD(P)H-quinone oxidoreductase subunit 1, chloroplastic
EC=1.6.5.-

Alternative name(s):
NAD(P)H dehydrogenase subunit 1
Short name=NDH subunit 1
NADH-plastoquinone oxidoreductase subunit 1

Gene names

Name:	ndhA
Ordered Locus Names:	Poptr_cp084

Encoded on

Plastid; Chloroplast

Organism

Populus trichocarpa (Western balsam poplar) (Populus balsamifera subsp. trichocarpa) [Reference proteome]

Taxonomic identifier

3694 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › fabids › Malpighiales › Salicaceae › Saliceae › Populus

Protein attributes

Sequence length	365 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient By similarity. HAMAP-Rule MF_01350
Catalytic activity	NAD(P)H + plastoquinone = NAD(P)+ + plastoquinol. HAMAP-Rule MF_01350
Subunit structure	NDH is composed of at least 16 different subunits, 5 of which are encoded in the nucleus By similarity.
Subcellular location	Plastid › chloroplast thylakoid membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01350.
Sequence similarities	Belongs to the complex I subunit 1 family.

Ontologies

Keywords
Cellular component	Chloroplast Membrane Plastid Thylakoid
Domain	Transmembrane Transmembrane helix
Ligand	NAD NADP Plastoquinone
Molecular function	Oxidoreductase
PTM	Quinone
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	photosynthesis, light reaction Inferred from electronic annotation. Source: HAMAP
Cellular_component	chloroplast thylakoid membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor Inferred from electronic annotation. Source: HAMAP quinone binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 365	365	NAD(P)H-quinone oxidoreductase subunit 1, chloroplastic HAMAP-Rule MF_01350		PRO_0000298880
Regions
	Transmembrane	30 – 50	21	Helical; Potential
	Transmembrane	104 – 124	21	Helical; Potential
	Transmembrane	129 – 149	21	Helical; Potential
	Transmembrane	253 – 273	21	Helical; Potential
	Transmembrane	302 – 322	21	Helical; Potential
	Transmembrane	338 – 358	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	A4GYX1 [UniParc]. Last modified April 17, 2007. Version 1. Checksum: DE2B0A12B481DE59	FASTA	365	40,394
	10 20 30 40 50 60 MIIDTTTVQA INSFSRLKSL NEVYGIIWML VPILTLVLGI TIGILVIVWL EREISAGIQQ 70 80 90 100 110 120 RIGPEYAGPF GVLQALADGT KLLFKENLFP SRGDTRLFSI GPSIAVISTL LSYSVIPFGY 130 140 150 160 170 180 HFVLADLNIG VFLWIAISSI APIGLLMSGY GSNNKYSFLG GLRAAAQSIS YEIPLTLCVL 190 200 210 220 230 240 SISLLSNSSS TVDIVEAQSK YGLGGWNLWR QPIGFIIFFI SSLAECERLP FDLPEAEEEL 250 260 270 280 290 300 VAGYQTEYSG IKFGLFYVAS YLNLLVSSLF VAVLYLGGWN ISIPYISVPE FFDFEINKVG 310 320 330 340 350 360 RVFGTTMGIL ITLVKTYLFL FIPITTRWTL PRLRMDQLLN LGWKFLLPIS LGNLLLTTSS QLFSL

References

[1]

"The genome of black cottonwood, Populus trichocarpa (Torr. & Gray)." Tuskan G.A., Difazio S., Jansson S., Bohlmann J., Grigoriev I., Hellsten U., Putnam N., Ralph S., Rombauts S., Salamov A., Schein J., Sterck L., Aerts A., Bhalerao R.R., Bhalerao R.P., Blaudez D., Boerjan W., Brun A. , Brunner A., Busov V., Campbell M., Carlson J., Chalot M., Chapman J., Chen G.-L., Cooper D., Coutinho P.M., Couturier J., Covert S., Cronk Q., Cunningham R., Davis J., Degroeve S., Dejardin A., dePamphilis C.W., Detter J., Dirks B., Dubchak I., Duplessis S., Ehlting J., Ellis B., Gendler K., Goodstein D., Gribskov M., Grimwood J., Groover A., Gunter L., Hamberger B., Heinze B., Helariutta Y., Henrissat B., Holligan D., Holt R., Huang W., Islam-Faridi N., Jones S., Jones-Rhoades M., Jorgensen R., Joshi C., Kangasjaervi J., Karlsson J., Kelleher C., Kirkpatrick R., Kirst M., Kohler A., Kalluri U., Larimer F., Leebens-Mack J., Leple J.-C., Locascio P., Lou Y., Lucas S., Martin F., Montanini B., Napoli C., Nelson D.R., Nelson C., Nieminen K., Nilsson O., Pereda V., Peter G., Philippe R., Pilate G., Poliakov A., Razumovskaya J., Richardson P., Rinaldi C., Ritland K., Rouze P., Ryaboy D., Schmutz J., Schrader J., Segerman B., Shin H., Siddiqui A., Sterky F., Terry A., Tsai C.-J., Uberbacher E., Unneberg P., Vahala J., Wall K., Wessler S., Yang G., Yin T., Douglas C., Marra M., Sandberg G., Van de Peer Y., Rokhsar D.S. Science 313:1596-1604(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Nisqually.

Cross-references

Sequence databases
EMBL GenBank DDBJ	EF489041 Genomic DNA. Translation: ABO36766.1.
RefSeq	YP_001109562.1. NC_009143.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	3694.estExt_Genewise1_v1.C_130550001.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4929745.
KEGG	pop:Poptr_cp084.
Phylogenomic databases
eggNOG	COG1005.
KO	K05572.
ProtClustDB	CHL00032.
Family and domain databases
HAMAP	MF_01350. NDH1_NuoH.
InterPro	IPR001694. NADH_UbQ_OxRdtase_su1/FPO. IPR018086. NADH_UbQ_OxRdtase_su1_CS. [Graphical view]
PANTHER	PTHR11432. PTHR11432. 1 hit.
Pfam	PF00146. NADHdh. 1 hit. [Graphical view]
PROSITE	PS00667. COMPLEX1_ND1_1. 1 hit. PS00668. COMPLEX1_ND1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NU1C_POPTR

Accession

Primary (citable) accession number: A4GYX1

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 21, 2007
Last sequence update:	April 17, 2007
Last modified:	April 3, 2013
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program