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Protein

Gap junction gamma-1 protein

Gene

GJC1

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-SSC-112303. Electric Transmission Across Gap Junctions.
R-SSC-190861. Gap junction assembly.

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction gamma-1 protein
Alternative name(s):
Connexin-45
Short name:
Cx45
Gap junction alpha-7 protein
Gene namesi
Name:GJC1
Synonyms:GJA7
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 12

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 22CytoplasmicSequence analysisAdd BLAST22
Transmembranei23 – 45HelicalSequence analysisAdd BLAST23
Topological domaini46 – 75ExtracellularSequence analysisAdd BLAST30
Transmembranei76 – 95HelicalSequence analysisAdd BLAST20
Topological domaini96 – 175CytoplasmicSequence analysisAdd BLAST80
Transmembranei176 – 198HelicalSequence analysisAdd BLAST23
Topological domaini199 – 228ExtracellularSequence analysisAdd BLAST30
Transmembranei229 – 248HelicalSequence analysisAdd BLAST20
Topological domaini249 – 396CytoplasmicSequence analysisAdd BLAST148

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003130061 – 396Gap junction gamma-1 proteinAdd BLAST396

Proteomic databases

PaxDbiA4GVD1.

Expressioni

Gene expression databases

BgeeiENSSSCG00000021306.
GenevisibleiA4GVD1. SS.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins. Interacts with CNST (By similarity).By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000021968.

Family & Domainsi

Sequence similaritiesi

Belongs to the connexin family. Gamma-type subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFK3. Eukaryota.
ENOG410Z7PN. LUCA.
GeneTreeiENSGT00840000129674.
HOGENOMiHOG000231126.
HOVERGENiHBG009576.
InParanoidiA4GVD1.
KOiK07616.
OMAiRWKQHRG.
OrthoDBiEOG091G08B8.
TreeFamiTF329606.

Family and domain databases

InterProiIPR000500. Connexin.
IPR002265. Connexin45.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 2 hits.
PfamiPF00029. Connexin. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
PR01136. CONNEXINA6.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4GVD1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWSFLTRLL EEIHNHSTFV GKIWLTVLIV FRIVLTAVGG ESIYYDEQSK
60 70 80 90 100
FVCNTEQPGC ENVCYDAFAP LSHVRFWVFQ IILVATPSVM YLGYAIHKIA
110 120 130 140 150
KMEHGEADKK AARSKPYAMR WKQHRALEET EEDHEEDPMM YPEMELESEK
160 170 180 190 200
ENKEQNQSKP KHDGRRRIRE DGLMKIYVLQ LLARTMFEVG FLIGQYFLYG
210 220 230 240 250
FQVHPFYVCS RVPCPHKIDC FISRPTEKTI FLLIMYGVTG LCLLLNIWEM
260 270 280 290 300
LHLGFGTIRD SLNSKRRELE DPGAYNYPFT WNTPSAPPGY NIAVKPDQIQ
310 320 330 340 350
YTELSNAKIA YKQNKANIAQ EQQYGSHEET LPADLETLQR EIRMAQERLD
360 370 380 390
LAIQAYNHQN NPHGPREKKA KVGSKAGSNK SSASSKSGDG KTSVWI
Length:396
Mass (Da):45,598
Last modified:April 17, 2007 - v1
Checksum:iDF10A8FD9C9A2F49
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF437944 mRNA. Translation: ABO28479.1.
RefSeqiNP_001090988.1. NM_001097519.1.
XP_005668761.1. XM_005668704.2.
XP_005668762.1. XM_005668705.2.
XP_005668763.1. XM_005668706.2.
XP_005668765.1. XM_005668708.2.
XP_013836322.1. XM_013980868.1.
UniGeneiSsc.43862.
Ssc.95427.

Genome annotation databases

EnsembliENSSSCT00000030363; ENSSSCP00000021968; ENSSSCG00000021306.
GeneIDi100048959.
KEGGissc:100048959.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF437944 mRNA. Translation: ABO28479.1.
RefSeqiNP_001090988.1. NM_001097519.1.
XP_005668761.1. XM_005668704.2.
XP_005668762.1. XM_005668705.2.
XP_005668763.1. XM_005668706.2.
XP_005668765.1. XM_005668708.2.
XP_013836322.1. XM_013980868.1.
UniGeneiSsc.43862.
Ssc.95427.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000021968.

Proteomic databases

PaxDbiA4GVD1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000030363; ENSSSCP00000021968; ENSSSCG00000021306.
GeneIDi100048959.
KEGGissc:100048959.

Organism-specific databases

CTDi10052.

Phylogenomic databases

eggNOGiENOG410IFK3. Eukaryota.
ENOG410Z7PN. LUCA.
GeneTreeiENSGT00840000129674.
HOGENOMiHOG000231126.
HOVERGENiHBG009576.
InParanoidiA4GVD1.
KOiK07616.
OMAiRWKQHRG.
OrthoDBiEOG091G08B8.
TreeFamiTF329606.

Enzyme and pathway databases

ReactomeiR-SSC-112303. Electric Transmission Across Gap Junctions.
R-SSC-190861. Gap junction assembly.

Gene expression databases

BgeeiENSSSCG00000021306.
GenevisibleiA4GVD1. SS.

Family and domain databases

InterProiIPR000500. Connexin.
IPR002265. Connexin45.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 2 hits.
PfamiPF00029. Connexin. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
PR01136. CONNEXINA6.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCXG1_PIG
AccessioniPrimary (citable) accession number: A4GVD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 17, 2007
Last modified: November 2, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.