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Protein

ETS domain-containing protein Elk-1

Gene

Elk1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor that binds to purine-rich DNA sequences. Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2 (By similarity) (PubMed:17156131). Induces target gene transcription upon JNK-signaling pathway stimulation (PubMed:17156131).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi5 – 86ETSPROSITE-ProRule annotationAdd BLAST82

GO - Molecular functioni

GO - Biological processi

  • cell differentiation Source: GO_Central
  • cellular response to gamma radiation Source: RGD
  • cellular response to lipid Source: RGD
  • cellular response to testosterone stimulus Source: RGD
  • positive regulation of neuron death Source: RGD
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • response to fibroblast growth factor Source: UniProtKB
  • response to light stimulus Source: RGD

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
ETS domain-containing protein Elk-1Curated
Gene namesi
Name:Elk1Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi1598663 Elk1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004339291 – 427ETS domain-containing protein Elk-1Add BLAST427

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki229Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Cross-linki248Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Cross-linki253Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Modified residuei323Phosphoserine; by MAPK1By similarity1
Modified residuei335Phosphothreonine; by MAPK1By similarity1
Modified residuei352Phosphothreonine; by MAPK1By similarity1
Modified residuei362Phosphothreonine; by MAPK1By similarity1
Modified residuei367Phosphothreonine; by MAPK1By similarity1
Modified residuei382Phosphoserine; by MAPK1 and MAPK8By similarity1
Modified residuei388Phosphoserine; by MAPK1By similarity1
Modified residuei416Phosphothreonine; by MAPK1By similarity1
Modified residuei421Phosphoserine; by MAPK1By similarity1

Post-translational modificationi

Sumoylation represses transcriptional activator activity as it results in recruitment of HDAC2 to target gene promoters which leads to decreased histone acetylation and reduced transactivator activity. It also regulates nuclear retention.By similarity
On mitogenic stimulation, phosphorylated on C-terminal serine and threonine residues by MAPK1. Ser-382 and Ser-388 are the preferred sites for MAPK1. In vitro, phosphorylation by MAPK1 potentiates ternary complex formation with the serum responses factors, SRE and SRF. Also phosphorylated on Ser-382 by MAPK8 and/or MAKP9. Phosphorylation leads to loss of sumoylation and restores transcriptional activator activity. Phosphorylated and activated by CAMK4, MAPK11, MAPK12 and MAPK14 (By similarity). Upon bFGF stimulus, phosphorylated by PAK1 (PubMed:17156131).By similarity1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiA4GTP4

PTM databases

iPTMnetiA4GTP4
PhosphoSitePlusiA4GTP4

Expressioni

Gene expression databases

BgeeiENSRNOG00000010171
GenevisibleiA4GTP4 RN

Interactioni

Subunit structurei

Interacts in its sumoylated form with PIAS2/PIASX which enhances its transcriptional activator activity. Interacts with MAD2L2; the interaction is direct and promotes phosphorylation by the kinases MAPK8 and/or MAPK9. Interacts with POU1F1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

CORUMiA4GTP4
STRINGi10116.ENSRNOP00000013522

Structurei

3D structure databases

ProteinModelPortaliA4GTP4
SMRiA4GTP4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni348 – 398Sufficient for interaction with MAD2L2By similarityAdd BLAST51

Sequence similaritiesi

Belongs to the ETS family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3806 Eukaryota
ENOG410Z0ZF LUCA
GeneTreeiENSGT00760000118907
HOGENOMiHOG000237332
HOVERGENiHBG004344
KOiK04375
OMAiRRATHRF
OrthoDBiEOG091G0CL4
PhylomeDBiA4GTP4
TreeFamiTF317732

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000418 Ets_dom
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00178 Ets, 1 hit
PRINTSiPR00454 ETSDOMAIN
SMARTiView protein in SMART
SM00413 ETS, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00345 ETS_DOMAIN_1, 1 hit
PS00346 ETS_DOMAIN_2, 1 hit
PS50061 ETS_DOMAIN_3, 1 hit

Sequencei

Sequence statusi: Complete.

A4GTP4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPSVTLWQF LLQLLREQGN GHIISWTSRD GGEFKLVDAE EVARLWGLRK
60 70 80 90 100
NKTNMNYDKL SRALRYYYDK NIIRKVSGQK FVYKFVSYPE VAGCSTEDCP
110 120 130 140 150
PQPEVSVTSA VAMAPATVHS GPGDNATGKP GTPKGAGMTG QGGLARSSRN
160 170 180 190 200
EYMRSGLYST FTIQSLQPQP PLHPRPASVL PNTTPAGVPA PPSGSRSTSP
210 220 230 240 250
NPLEACLEAE EAGLPLQVIL TPPEAPNQKS EELSLNPGFG RPQPPEVKVE
260 270 280 290 300
GPKEELEVTE VGGFSPEAVK AEQEVSPSEG LLARLPAILT ENTAQVCGLS
310 320 330 340 350
TSTTEITQPQ KGRKPRDLEL PLSPSLLGGQ GPERTPGSGT SSGLQAQGPA
360 370 380 390 400
LTPSLLPTHT LTPVLLTPSS LPPSIHFWST LSPIAPRSPA KLSFQFPSSG
410 420
SAQVHIPSIS VDGLSTPVVL SPGPQKP
Length:427
Mass (Da):45,272
Last modified:April 17, 2007 - v1
Checksum:iC318C5A55E4785E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF429098 mRNA Translation: ABO27185.1
AABR07036739 Genomic DNA No translation available.
CH474009 Genomic DNA Translation: EDL97728.1
RefSeqiNP_001101529.1, NM_001108059.3
XP_006256676.1, XM_006256614.2
UniGeneiRn.203416

Genome annotation databases

EnsembliENSRNOT00000013522; ENSRNOP00000013522; ENSRNOG00000010171
GeneIDi314436
KEGGirno:314436
UCSCiRGD:1598663 rat

Similar proteinsi

Entry informationi

Entry nameiELK1_RAT
AccessioniPrimary (citable) accession number: A4GTP4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 14, 2015
Last sequence update: April 17, 2007
Last modified: May 23, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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