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A4GT88 (IOD1_RABIT) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Type I iodothyronine deiodinase

EC=1.97.1.10
Alternative name(s):
5DI
DIOI
Type 1 DI
Type-I 5'-deiodinase
Gene names
Name:DIO1
OrganismOryctolagus cuniculus (Rabbit) [Reference proteome]
Taxonomic identifier9986 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus

Protein attributes

Sequence length249 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine) By similarity.

Catalytic activity

3,5,3'-triiodo-L-thyronine + iodide + A + H+ = L-thyroxine + AH2.

Subcellular location

Endoplasmic reticulum membrane; Single-pass membrane protein By similarity.

Sequence similarities

Belongs to the iodothyronine deiodinase family.

Ontologies

Keywords
   Biological processThyroid hormones biosynthesis
   Cellular componentEndoplasmic reticulum
Membrane
   Coding sequence diversitySelenocysteine
   DomainTransmembrane
Transmembrane helix
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processhormone biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionthyroxine 5'-deiodinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 249249Type I iodothyronine deiodinase
PRO_0000318639

Regions

Transmembrane13 – 3321Helical; Potential

Sites

Active site1261

Amino acid modifications

Non-standard residue1261Selenocysteine

Sequences

Sequence LengthMass (Da)Tools
A4GT88 [UniParc].

Last modified February 26, 2008. Version 2.
Checksum: 36D30DA30BA72D30

FASTA24928,526
        10         20         30         40         50         60 
MGLPRPGLWL KRLWVLVQVA VEVAVGKVLM TLFPERVKQN ILAMGQKTGI AQNPNFAQDS 

        70         80         90        100        110        120 
WIPTFFSTQY FWFVLKVRWQ RLEDATEPGG LAPNCSVVRL SGQQCSVWDF MRGNRPLVLN 

       130        140        150        160        170        180 
FGSCTUPSFL SKFDQFKRLI QDFSSIADFL IIYIEEAHAS DGWAFKNNVD IKNHRNLQDR 

       190        200        210        220        230        240 
LRAASLLLAR SPQCPVVVDT MQNQSSQLYA ALPERLYVLR QGRILYKGES GPWNYNPEEV 


RAVLEELHS 

« Hide

References

[1]"Regulation of tissue iodothyronine deiodinase activity in a model of prolonged critical illness."
Debaveye Y., Ellger B., Mebis L., Darras V.M., Van den Berghe G.
Thyroid 18:551-560(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
EF428025 mRNA. Translation: ABO21318.1.
RefSeqNP_001093428.1. NM_001099958.1.
UniGeneOcu.7145.

3D structure databases

ProteinModelPortalA4GT88.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9986.ENSOCUP00000007619.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100101570.

Organism-specific databases

CTD1733.

Phylogenomic databases

eggNOGNOG149534.
HOVERGENHBG000099.

Family and domain databases

Gene3D3.40.30.10. 1 hit.
InterProIPR000643. Iodothyronine_deiodinase.
IPR008261. Iodothyronine_deiodinase_AS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERPTHR11781. PTHR11781. 1 hit.
PfamPF00837. T4_deiodinase. 1 hit.
[Graphical view]
PIRSFPIRSF001330. IOD. 1 hit.
SUPFAMSSF52833. SSF52833. 1 hit.
PROSITEPS01205. T4_DEIODINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIOD1_RABIT
AccessionPrimary (citable) accession number: A4GT88
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: February 19, 2014
This is version 44 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families