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A4GT88

- IOD1_RABIT

UniProt

A4GT88 - IOD1_RABIT

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Protein

Type I iodothyronine deiodinase

Gene

DIO1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine).By similarity

Catalytic activityi

3,5,3'-triiodo-L-thyronine + iodide + A + H+ = L-thyroxine + AH2.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei126 – 1261

GO - Molecular functioni

  1. thyroxine 5'-deiodinase activity Source: UniProtKB-EC

GO - Biological processi

  1. hormone biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Thyroid hormones biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Type I iodothyronine deiodinase (EC:1.97.1.10)
Alternative name(s):
5DI
DIOI
Type 1 DI
Type-I 5'-deiodinase
Gene namesi
Name:DIO1
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 249249Type I iodothyronine deiodinasePRO_0000318639Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000007619.

Structurei

3D structure databases

ProteinModelPortaliA4GT88.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei13 – 3321HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the iodothyronine deiodinase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG149534.
HOVERGENiHBG000099.
InParanoidiA4GT88.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR000643. Iodothyronine_deiodinase.
IPR008261. Iodothyronine_deiodinase_AS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11781. PTHR11781. 1 hit.
PfamiPF00837. T4_deiodinase. 1 hit.
[Graphical view]
PIRSFiPIRSF001330. IOD. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS01205. T4_DEIODINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4GT88 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGLPRPGLWL KRLWVLVQVA VEVAVGKVLM TLFPERVKQN ILAMGQKTGI
60 70 80 90 100
AQNPNFAQDS WIPTFFSTQY FWFVLKVRWQ RLEDATEPGG LAPNCSVVRL
110 120 130 140 150
SGQQCSVWDF MRGNRPLVLN FGSCTUPSFL SKFDQFKRLI QDFSSIADFL
160 170 180 190 200
IIYIEEAHAS DGWAFKNNVD IKNHRNLQDR LRAASLLLAR SPQCPVVVDT
210 220 230 240
MQNQSSQLYA ALPERLYVLR QGRILYKGES GPWNYNPEEV RAVLEELHS
Length:249
Mass (Da):28,526
Last modified:February 26, 2008 - v2
Checksum:i36D30DA30BA72D30
GO

Non-standard residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-standard residuei126 – 1261Selenocysteine

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EF428025 mRNA. Translation: ABO21318.1.
RefSeqiNP_001093428.1. NM_001099958.1.
UniGeneiOcu.7145.

Genome annotation databases

GeneIDi100101570.

Keywords - Coding sequence diversityi

Selenocysteine

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EF428025 mRNA. Translation: ABO21318.1 .
RefSeqi NP_001093428.1. NM_001099958.1.
UniGenei Ocu.7145.

3D structure databases

ProteinModelPortali A4GT88.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9986.ENSOCUP00000007619.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100101570.

Organism-specific databases

CTDi 1733.

Phylogenomic databases

eggNOGi NOG149534.
HOVERGENi HBG000099.
InParanoidi A4GT88.

Family and domain databases

Gene3Di 3.40.30.10. 1 hit.
InterProi IPR000643. Iodothyronine_deiodinase.
IPR008261. Iodothyronine_deiodinase_AS.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
PANTHERi PTHR11781. PTHR11781. 1 hit.
Pfami PF00837. T4_deiodinase. 1 hit.
[Graphical view ]
PIRSFi PIRSF001330. IOD. 1 hit.
SUPFAMi SSF52833. SSF52833. 1 hit.
PROSITEi PS01205. T4_DEIODINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Regulation of tissue iodothyronine deiodinase activity in a model of prolonged critical illness."
    Debaveye Y., Ellger B., Mebis L., Darras V.M., Van den Berghe G.
    Thyroid 18:551-560(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiIOD1_RABIT
AccessioniPrimary (citable) accession number: A4GT88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: October 29, 2014
This is version 46 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3