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Protein

Gap junction gamma-1 protein

Gene

Gjc1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.By similarity

GO - Molecular functioni

  • gap junction channel activity Source: RGD
  • ion channel activity Source: Ensembl

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-112303. Electric Transmission Across Gap Junctions.
R-RNO-190861. Gap junction assembly.

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction gamma-1 protein
Alternative name(s):
Connexin-45
Short name:
Cx45
Gap junction alpha-7 protein
Gene namesi
Name:Gjc1
Synonyms:Gja7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi628889. Gjc1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 18CytoplasmicSequence analysisAdd BLAST18
Transmembranei19 – 39HelicalSequence analysisAdd BLAST21
Topological domaini40 – 75ExtracellularSequence analysisAdd BLAST36
Transmembranei76 – 96HelicalSequence analysisAdd BLAST21
Topological domaini97 – 175CytoplasmicSequence analysisAdd BLAST79
Transmembranei176 – 198HelicalSequence analysisAdd BLAST23
Topological domaini199 – 229ExtracellularSequence analysisAdd BLAST31
Transmembranei230 – 250HelicalSequence analysisAdd BLAST21
Topological domaini251 – 396CytoplasmicSequence analysisAdd BLAST146

GO - Cellular componenti

  • connexin complex Source: Ensembl
  • gap junction Source: RGD
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003695431 – 396Gap junction gamma-1 proteinAdd BLAST396

Proteomic databases

PaxDbiA4GG66.
PRIDEiA4GG66.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSRNOG00000048838.
GenevisibleiA4GG66. RN.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins. Interacts with CNST (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066371.

Structurei

3D structure databases

ProteinModelPortaliA4GG66.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili303 – 358Sequence analysisAdd BLAST56

Sequence similaritiesi

Belongs to the connexin family. Gamma-type subfamily.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFK3. Eukaryota.
ENOG410Z7PN. LUCA.
GeneTreeiENSGT00840000129674.
InParanoidiA4GG66.
KOiK07616.
OMAiRWKQHRG.
OrthoDBiEOG091G08B8.
PhylomeDBiA4GG66.

Family and domain databases

InterProiIPR000500. Connexin.
IPR002265. Connexin45.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 2 hits.
PfamiPF00029. Connexin. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
PR01136. CONNEXINA6.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4GG66-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWSFLTRLL EEIHNHSTFV GKIWLTVLIV FRIVLTAVGG ESIYYDEQSK
60 70 80 90 100
FVCNTEQPGC ENVCYDAFAP LSHVRFWVFQ IILVATPSVM YLGYAIHKIA
110 120 130 140 150
KMEHGEADKK AARSKPYAMR WKQHRALEET EEDHEEDPMM YPEMELESEK
160 170 180 190 200
ENKEQSQPKP KHDGRRRIRE DGLMKIYVLQ LLARTVFEVG FLIGQYFLYG
210 220 230 240 250
FQVHPFYVCS RLPCPHKIDC FISRPTEKTI FLLIMYGVTG LCLLLNIWEM
260 270 280 290 300
LHLGFGTIRD SLNSKRRELD DPGAYNYPFT WNTPSAPPGY NIAVKPDQIQ
310 320 330 340 350
YTELSNAKIA YKQNKANIAQ EQQYGSHEEH LPADLETLQR EIRMAQERLD
360 370 380 390
LAIQAYHHQN NPHGPREKKA KVGSKSGSNK SSISSKSGDG KTSVWI
Length:396
Mass (Da):45,666
Last modified:April 17, 2007 - v1
Checksum:i9CD5721BB071B65C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ871218 Genomic DNA. Translation: ABI54096.1.
DQ871218 Genomic DNA. Translation: ABI54097.1.
DQ871218 Genomic DNA. Translation: ABI54098.1.
DQ871218 Genomic DNA. Translation: ABI54099.1.
CH473948 Genomic DNA. Translation: EDM06232.1.
BC166405 mRNA. Translation: AAI66405.1.
RefSeqiNP_001078850.1. NM_001085381.1.
XP_017452538.1. XM_017597049.1.
XP_017452539.1. XM_017597050.1.
UniGeneiRn.195419.

Genome annotation databases

EnsembliENSRNOT00000073372; ENSRNOP00000066371; ENSRNOG00000048838.
GeneIDi266706.
KEGGirno:266706.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ871218 Genomic DNA. Translation: ABI54096.1.
DQ871218 Genomic DNA. Translation: ABI54097.1.
DQ871218 Genomic DNA. Translation: ABI54098.1.
DQ871218 Genomic DNA. Translation: ABI54099.1.
CH473948 Genomic DNA. Translation: EDM06232.1.
BC166405 mRNA. Translation: AAI66405.1.
RefSeqiNP_001078850.1. NM_001085381.1.
XP_017452538.1. XM_017597049.1.
XP_017452539.1. XM_017597050.1.
UniGeneiRn.195419.

3D structure databases

ProteinModelPortaliA4GG66.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066371.

Proteomic databases

PaxDbiA4GG66.
PRIDEiA4GG66.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000073372; ENSRNOP00000066371; ENSRNOG00000048838.
GeneIDi266706.
KEGGirno:266706.

Organism-specific databases

CTDi10052.
RGDi628889. Gjc1.

Phylogenomic databases

eggNOGiENOG410IFK3. Eukaryota.
ENOG410Z7PN. LUCA.
GeneTreeiENSGT00840000129674.
InParanoidiA4GG66.
KOiK07616.
OMAiRWKQHRG.
OrthoDBiEOG091G08B8.
PhylomeDBiA4GG66.

Enzyme and pathway databases

ReactomeiR-RNO-112303. Electric Transmission Across Gap Junctions.
R-RNO-190861. Gap junction assembly.

Miscellaneous databases

PROiA4GG66.

Gene expression databases

BgeeiENSRNOG00000048838.
GenevisibleiA4GG66. RN.

Family and domain databases

InterProiIPR000500. Connexin.
IPR002265. Connexin45.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 2 hits.
PfamiPF00029. Connexin. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
PR01136. CONNEXINA6.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCXG1_RAT
AccessioniPrimary (citable) accession number: A4GG66
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: April 17, 2007
Last modified: November 30, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.