A4GCM7RDRP_I35A3RNA-directed RNA polymerase catalytic subunit2.7.7.48Polymerase basic protein 1PB1RNA-directed RNA polymerase subunit P1PB1Influenza A virus (strain A/USA:Phila/1935 H1N1)VirusesRiboviriaOrthornaviraeNegarnaviricotaPolyploviricotinaInsthoviricetesArticulaviralesOrthomyxoviridaeAlphainfluenzavirusAlphainfluenzavirus influenzaeInfluenza A virusAvesHomo sapiensHumanSus scrofaPigThe NIAID influenza genome sequencing project.NUCLEOTIDE SEQUENCE [GENOMIC RNA]NUCLEOTIDE SEQUENCE [GENOMIC RNA]RNA-dependent RNA polymerase which is responsible for replication and transcription of virus RNA segments. The transcription of viral mRNAs occurs by a unique mechanism called cap-snatching. 5' methylated caps of cellular mRNAs are cleaved after 10-13 nucleotides by PA. In turn, these short capped RNAs are used as primers by PB1 for transcription of viral mRNAs. During virus replication, PB1 initiates RNA synthesis and copy vRNA into complementary RNA (cRNA) which in turn serves as a template for the production of more vRNAs.a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)Influenza RNA polymerase is composed of three subunits: PB1, PB2 and PA. Interacts (via N-terminus) with PA (via C-terminus). Interacts (via C-terminus) with PB2 (via N-terminus); this interaction is essential for transcription initiation. Interacts (via C-terminus) with human PKP2 (via N-terminus); the interaction competitively inhibits the interaction between the RNA polymerase subunits PB1 and PB2 (By similarity).Host nucleusHost cytoplasmPhosphorylated by host PRKCA.Belongs to the influenza viruses polymerase PB1 family.Eukaryotic host gene expression shutoff by virusEukaryotic host transcription shutoff by virusHost cytoplasmHost gene expression shutoff by virusHost nucleusHost-virus interactionInhibition of host RNA polymerase II by virusNucleotide-bindingNucleotidyltransferasePhosphoproteinRNA-directed RNA polymeraseTransferaseViral RNA replicationViral transcriptionMDVNPTLLFLKVPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYSERGRWTTNTETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHPGIFENSCIETMEVVQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVFRSNGLTANESGRLIDFLKDVMESMNKEEMEITTHFQRKRRVRDNMTKKMVTQRTIGKRKQKLNKRSYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRGFVYFVETLARSICEKLEQSGLPVGGNEKKAKLANVVRKMMTNSQDTELSFTITGDNTKWNENQNPRMFLAMITYMTRNQPEWFRNVLSIAPIMFSNKMARLGKGYMFESKSMKLRTQIPAEMLASIDLKYFNGSTRKKIEKIRPLLIEGTASLSPGMMMGMFNMLSTVLGVSILNLGQKRYTKTTYWWDGLQSSDDFALIVNAPNHEGIQAGVDRFYRTCKLLGINMSKKKSYINRTGTFEFTSFFYRYGFVANFSMELPSFGVSGINESADMSIGVTVIKNNMINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQIQTRRSFEIKKLWEQTRSKAGLLVSDGGPNLYNIRNLHIPEVCLKWELMDEDYQGRLCNPLNPFVSHKEIESMNNAVMMPAHGPAKNMEYDAVATTHSWIPKRNRSILNTSQRGILEDEQMYQRCCNLFEXFFPSSSYRRPVGISSMVEAMVSRAQIDARIDFESGRIKKEEFTEIMKICSTIEELRRQK
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