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A4GCL8

- PB2_I43A0

UniProt

A4GCL8 - PB2_I43A0

Protein

Polymerase basic protein 2

Gene

PB2

Organism
Influenza A virus (strain A/USA:Iowa/1943 H1N1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (17 Apr 2007)
      Previous versions | rss
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    Functioni

    Involved in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNA are used to generate primers for viral transcription. Binds the cap of the target pre-RNA which is subsequently cleaved by PB1. May play a role in genome replication By similarity.By similarity

    GO - Molecular functioni

    1. RNA binding Source: InterPro
    2. RNA-directed RNA polymerase activity Source: InterPro

    GO - Biological processi

    1. 7-methylguanosine mRNA capping Source: UniProtKB-KW
    2. cap snatching Source: UniProtKB-KW
    3. suppression by virus of host RNA polymerase II activity Source: UniProtKB-KW
    4. transcription, DNA-templated Source: InterPro

    Keywords - Biological processi

    Cap snatching, Eukaryotic host gene expression shutoff by virus, Eukaryotic host transcription shutoff by virus, Host gene expression shutoff by virus, Host-virus interaction, Inhibition of host RNA polymerase II by virus, mRNA capping, mRNA processing

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polymerase basic protein 2
    Gene namesi
    Name:PB2
    OrganismiInfluenza A virus (strain A/USA:Iowa/1943 H1N1)
    Taxonomic identifieri425563 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesOrthomyxoviridaeInfluenzavirus A
    Virus hostiAves [TaxID: 8782]
    Homo sapiens (Human) [TaxID: 9606]
    Sus scrofa (Pig) [TaxID: 9823]
    ProteomesiUP000008432: Genome

    Subcellular locationi

    GO - Cellular componenti

    1. host cell mitochondrion Source: UniProtKB-SubCell
    2. host cell nucleus Source: UniProtKB-SubCell
    3. virion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host mitochondrion, Host nucleus, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 759759Polymerase basic protein 2PRO_0000373033Add
    BLAST

    Interactioni

    Subunit structurei

    Influenza RNA polymerase is composed of three subunits: PB1, PB2 and PA.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliA4GCL8.
    SMRiA4GCL8. Positions 319-483, 685-759.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi736 – 7394Nuclear localization signalBy similarity

    Sequence similaritiesi

    Belongs to the influenza viruses PB2 family.Curated

    Family and domain databases

    InterProiIPR001591. RNA_pol_PB2_orthomyxovir.
    [Graphical view]
    PfamiPF00604. Flu_PB2. 1 hit.
    [Graphical view]
    ProDomiPD001667. RNA_pol_PB2_orthomyxovir. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    A4GCL8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MERIKELRNL MSQSRTREIL TKTTVDHMAI IKKYTSGRQE KNPSLRMKWM    50
    MAMKYPITAD KRITEMIPER NEQGQTLWSK MNDAGSDRVM VSPLAVTWWN 100
    RNGPMTSTVH YPKIYKTYFE KVERLKHGTF GPVHFRNQVK IRRRVDINPG 150
    HADLSAKEAQ DVIMEVVFPN EVGARILTSE SQLTITKEKK EELQDCKISP 200
    LMVAYMLERE LVRKTRFLPV AGGTSSVYIE VLHLTQGTCW EQMYTPGGEV 250
    RNDDVDQSLI IAARNIVRRA AVSADPLASL LEMCHSTQIG GTRMVDILRQ 300
    NPTEEQAVDI CKAAMGLRIS SSFSFGGFTF KRTSGSSVKR EEEVLTGNLQ 350
    TLKIRVHEGY EEFTMVGRRA TAILRKATRR LIQLIVSGKD EQSIAEAIIV 400
    AMVFSQEDCM IKAVRGDLNF VNRANQRLNP MHQLLRHFQK DAKVLFQNWG 450
    IEPIDNVMGM IGILPDMTPS TEVSMRGVRV SKMGVDEYSN AERVVVSIDR 500
    FLRVRDQRGN VLLSPEEVSE TQGTEKLTIT YSSSMMWEIN GPESVLVNTY 550
    QWIIRNWETV KIQWSQNPTM LYNKMEFEPF QSLVPKAIRG QYSGFVRTLF 600
    QQMRDVLGTF DTTQIIKLLP FAAAPPKQSR MQFSSLTVNV RGSGMRILVR 650
    GNSPVFNYNK ATKRLTVLGK DAGTLTEDPD EGTSGVESAV LRGFLILGKE 700
    DRRYGPALSI NELSNLAKGE KANVLIGQGD VVLVMKRKRD SSILTDSQTA 750
    TKRIRMAIN 759
    Length:759
    Mass (Da):86,012
    Last modified:April 17, 2007 - v1
    Checksum:i23514DD0C65246E9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CY020468 Viral cRNA. Translation: ABO38383.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CY020468 Viral cRNA. Translation: ABO38383.1 .

    3D structure databases

    ProteinModelPortali A4GCL8.
    SMRi A4GCL8. Positions 319-483, 685-759.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR001591. RNA_pol_PB2_orthomyxovir.
    [Graphical view ]
    Pfami PF00604. Flu_PB2. 1 hit.
    [Graphical view ]
    ProDomi PD001667. RNA_pol_PB2_orthomyxovir. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. The NIAID Influenza Genome Sequencing Consortium
      Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiPB2_I43A0
    AccessioniPrimary (citable) accession number: A4GCL8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 5, 2009
    Last sequence update: April 17, 2007
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3